Effect of intravenous corynebacterium parvum on peripheral-blood effector cells of cancer patients

Gill, P. Grantley; Waller, C. A.; MacClennan, I C; Morris, Peter J.

doi:10.1038/bjc.1980.142

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…injection of Cparvum (Gill et al, 1980), blood polymorphs were markedly increased 24 h after i.p. Cparvum, and returned to normal values thereafter.…”

Section: Patients and Treatmentmentioning

confidence: 96%

Intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: Effects on cytotoxicity of tumor‐associated macrophages and NK cells

Mantovani

Sessa

Peri

et al. 1981

Intl Journal of Cancer

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Eight ovarian cancer patients with ascites resistant to various chemotherapy protocols were treated i.p. with C. parvum in an effort to obtain a palliative reduction of peritoneal effusions. C. parvum(7–14 mg) was given i.p. on days 0, 7, 28 and then at monthly intervals. Three patients showed no clinical evidence of therapeutic benefit from C. parvum administration. Three subjects had a complete disappearance of ascites, and two additional patients showed a marked reduction of their effusions. Solid tumor masses were not affected by i.p. C. parvum. C. parvum injection caused a rapid decrease of the percentage of tumor cells in the ascites as early as 7–15 days after the first treatment. Concomitantly, the percentage of polymorphs and, to a lesser extent, of macrophages in the ascitic tumor increased, whereas tumor‐associated lymphoid cells (TAL) were not altered in a consistent pattern. The tumoricidal activity of peripheral blood monocytes and natural killer (NK) cells was not consistently modified after C. parvum treatment. Pretreatment NK activity of TAL was usually very low and was not appreciably modified by i.p. C. parvum. In one patient, whose TAL had NK activity in the range of normal PBL, C. parvum administration was followed by a profound depression of intratumor NK cytotoxicity. The tumoricidal activity of tumor‐associated macrophages (TAM) was not enhanced following C. parvum administration; 14–21 days after the first C. parvum inoculation, a marked decrease of the cytolytic capacity of TAM was observed, cytotoxicity returning to pretreatment values thereafter. These observations do not elucidate the mechanism of the limited, but significant, anti‐tumor activity of i.p. C. parvum in human ovarian carcinomatous ascites. The lack of enhancement of macrophage cytotoxicity after i.p. C. parvum, predicted on the basis of data in rodents, cautions against the empirical use in humans of agents assumed to affect human neoplasia through activation of host defense mechanisms.

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“…injection of Cparvum (Gill et al, 1980), blood polymorphs were markedly increased 24 h after i.p. Cparvum, and returned to normal values thereafter.…”

Section: Patients and Treatmentmentioning

confidence: 96%

Intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: Effects on cytotoxicity of tumor‐associated macrophages and NK cells

Mantovani

Sessa

Peri

et al. 1981

Intl Journal of Cancer

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Indomethacin, Prostaglandin, and Immune Regulation in Melanoma

Balch

Tilden

1982

Melanoma Antigens and Antibodies

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Comparative Study of Chemotherapy and/or Immunotherapy of Established Experimental Brain Tumors

Kida

Cravioto

1985

Neurol. Med. Chir.(Tokyo)

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Intracerebral injection of 5 × 10⁵ nitrosourea-induced glioma cells (T₉ tissue culture line) consistently produced brain tumors in syngenic Cesarean Derived Fisher rats. The tumors were 1 mm in diameter within 7 days and caused death within 23 days (mean results). The effects of therapy with ACNU and/or Corynebacterium parvum (C. parvum) were evaluated. C. parvum alone was apparently in effective. ACNU (10 mg/kg body weight) given on days 7 and 14 prolonged the mean survival time to 33.4 days. Combined treatment with ACNU and intradermal immunization with T₉ cells and C. par vum on days 7 and 14, or on days 0 and 7, prolonged the mean survival time to 35.3 and 39.6 days, respectively. Eleven rats that survived following this treatment showed specific immunity against T₉ cells, as demonstrated by subsequent challenge with T9 cells. The Winn's test procedure showed that spleen lymphocytes from immune rats were effective against T9 cells. The results suggest that im munochemotherapy may be an effective treatment for rats with established brain tumors.

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Effect of intravenous corynebacterium parvum on peripheral-blood effector cells of cancer patients

Cited by 3 publications

References 12 publications

Intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: Effects on cytotoxicity of tumor‐associated macrophages and NK cells

Intraperitoneal administration of corynebacterium parvum in patients with ascitic ovarian tumors resistant to chemotherapy: Effects on cytotoxicity of tumor‐associated macrophages and NK cells

Indomethacin, Prostaglandin, and Immune Regulation in Melanoma

Comparative Study of Chemotherapy and/or Immunotherapy of Established Experimental Brain Tumors

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