Effect of intravenous corticosteroid on ex vivo leukotriene generation by blood leucocytes of normal and asthmatic patients

Hood, P. P.; Cotter, Timothy P; Costello, John; Sampson, Anthony P.

doi:10.1136/thx.54.12.1075

Cited by 33 publications

(13 citation statements)

References 35 publications

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“…Other investigators also reported that LT production in PMNs was increased in patients with bronchial asthma (16)(17)(18)(19)(20), but the mechanisms were not clarified. Not many studies were conducted to assess possible molecular mechanisms of LT-synthesizing enzymes in asthma, especially in asthmatic children.…”

Section: Discussionmentioning

confidence: 93%

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children

Zaitsu¹,

Hamasaki²,

Matsuo³

et al. 2003

Journal of Asthma

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Leukotrienes (LTs) are recognized to be important mediators in asthma. Recent studies revealed that LT synthesis is controlled by the regulation of LT-synthesizing enzymes. We determined the synthesis of LTB4 and LTC4 by specific radioimmunoassay, and the messenger RNA (mRNA) expression of LT-synthesizing enzymes by reverse transcriptase polymerase chain reaction in peripheral polymorphonuclear leukocytes, which were obtained from controls and asthmatic children. The synthesis of LTB4 and LTC4, and the mRNA expression of 5-lipoxygenase, LTA4 hydrolase, and LTC4 synthase were enhanced in the patients. The mRNA expression of LT-synthesizing enzymes was up-regulated, resulting in increased LT synthesis, which may play an important role in the pathogenesis of childhood asthma.

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Section: Discussionmentioning

confidence: 93%

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children

Zaitsu¹,

Hamasaki²,

Matsuo³

et al. 2003

Journal of Asthma

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“…[5][6][7] They have an anti-inflammatory action by inhibiting prostaglandin and leukotriene production, and by eliciting apoptosis in inflammatory cells such as T-lymphocytes. 8,9 The exact mechanism of action of triamcinolone, concerning reduction of macular oedema, remains uncertain. Intravitreal steroids have been shown to stabilise the blood-retinal barrier after retinal photocoagulation and to reduce the vitreous cavity concentration of vascular endothelial growth factor.…”

Section: Discussionmentioning

confidence: 99%

Ocular morbidity associated with intravitreal triamcinolone acetonide

Konstantopoulos¹,

Williams²,

Newsom³

et al. 2006

Eye

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Aim To report on the complications associated with the use of intravitreal triamcinolone acetonide (IVTA) in a tertiary referral hospital setting. Materials and methods A retrospective case series review of all IVTA injections carried out over a period of 30 months. Results One hundred and thirty IVTA injections were performed; nine with limited local follow-up were excluded. Thus, 121 injections (108 patients, 114 eyes) were included in the study. Triamcinolone (4 mg) was used in all cases. Indications were diabetic macular oedema (n ¼ 41 eyes), retinal vein occlusions (n ¼ 27), postoperative cystoid macular oedema (n ¼ 24), exudative age-related macular degeneration (n ¼ 16), and others (n ¼ 6). No intraoperative complications were recorded. Postoperative intraocular pressure (IOP) readings of 22, 28, 35, and 40 mmHg or higher were recorded in 46.5, 29.8, 12.3, and 7.9% of eyes, respectively. IOP elevation was treated with antiglaucoma medication in all but one eye (0.9%) that required trabeculectomy and one (0.9%) that required vitrectomy with cataract extraction for suspected phacoanaphylactic glaucoma. Two eyes (1.8%) developed retinal detachment; both had previously been treated for retinal breaks. One eye (0.9%) developed culture-positive endophthalmitis. Conclusions Significant morbidity is associated with IVTA injection; clinicians should be aware when considering treatment options.

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“…Corticosteroids have been shown to reduce the breakdown of the blood-retinal barrier by inhibiting prostaglandins and inflammatory adhesion molecules and downregulate the production of vascular endothelial growth factor [7][8][9]. A few studies reported the efficacy of intravitreal triamcinolone (IVT) for the management of post-vitrectomy diabetic vitreous hemorrhage [10,11].…”

Section: Introductionmentioning

confidence: 99%

Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study

Park

Shin

Kim

2009

Graefes Arch Clin Exp Ophthalmol

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Effect of intravenous corticosteroid on ex vivo leukotriene generation by blood leucocytes of normal and asthmatic patients

Cited by 33 publications

References 35 publications

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children

Ocular morbidity associated with intravitreal triamcinolone acetonide

Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study

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Effect of intravenous corticosteroid on ex vivo leukotriene generation by blood leucocytes of normal and asthmatic patients

Cited by 33 publications

References 35 publications

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A4Hydrolase, and Leukotriene C4Synthase in Asthmatic Children

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A4Hydrolase, and Leukotriene C4Synthase in Asthmatic Children

Ocular morbidity associated with intravitreal triamcinolone acetonide

Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative study

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Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children

Leukotriene Synthesis Is Increased by Transcriptional Up-Regulation of 5-Lipoxygenase, Leukotriene A₄Hydrolase, and Leukotriene C₄Synthase in Asthmatic Children