Effect of intravenous administration of lidocaine on the ED50 of propofol induction dose during gastroscopy in adult patients: A randomized, controlled study

Abstract

What is known and Objective: Propofol provides a prominent sedation effect in gastroscopy. However, sedation with propofol alone during gastroscopy might result in circulatory and respiratory depression.

Impact of intravenous and topical lidocaine on clinical outcomes in patients receiving propofol for gastrointestinal endoscopic procedures: a meta-analysis of randomised controlled trials

“…lidocaine during gastroscopy in adult patients. 30 The total dosage of propofol was unavailable in that study. 30 Pooled results demonstrated a lower propofol dosage during GEPs in the lidocaine group compared with that in the placebo group (SMD¼À0.41, 95% CI: À0.67 to À0.14, P¼0.003; I 2 ¼83%) (Fig.…”

“…22,27,32e34 Focusing on the administration strategy of i.v. lidocaine, two studies 25,30 used an i.v. bolus of 1.5 mg kg À1 without subsequent infusion, while the same bolus dosage was adopted followed by a continuous lidocaine infusion at a dose of 4 mg kg À1 h À1 in two trials 21,26 and 2 mg kg À1 h À1 in three trials.…”

Estimation of the ED50 of propofol with intravenous lidocaine for inserting gastroscope without body movement in adult patients: A randomized, controlled study

“…However, the effect of intravenous lidocaine on the ED 50 of propofol's induction dose for gastroscopy is still unknown. Although Liu 19 et al already found that intravenous lidocaine decreased propofol's ED 50 from 2.01mg/kg to 1.69mg/kg. In this study, sufentanil was given in addition to lidocaine.…”

“…In recent years, intravenous lidocaine has been widely used as a perioperative analgesic agent 16 , especially in the management of acute pain in Scottish hospitals 30 . According to previous reports [31][32][33] , the dosage of intravenous lidocaine injection in this study was selected as 1.5mg/kg, resulting in signi cant propofol-sparing effect.…”

“…19 et al has found that the ED 50 of propofol with a single intravenous bolus of 1.5 mg/kg lidocaine was 1.69 mg/kg [95%CI (1.62-1.78) mg/kg] in adult patients for gastroscopy, while sufentanil also worked. As propofol combined with sufentanil not only results in better analgesia, less cough, and lower propofol dosage, but also more severe respiratory depression sometimes 9 − 11 .…”