Effect of intrauterine injection of human chorionic gonadotropin before frozen–thawed embryo transfer on pregnancy outcomes in women with endometriosis

Abstract

Objective To investigate the effect of human chorionic gonadotropin (hCG) intrauterine injection before frozen–thawed embryo transfer (FET) in women with endometriosis. Methods This retrospective cohort study included 45 women with endometriosis who underwent hCG intrauterine injection before FET; each woman was matched with three patients with endometriosis who did not receive hCG intrauterine injection (controls). Data on pregnancy and prenatal outcomes were extracted from medical records and compared. Results Patients in the hCG intrauterine injection group had significantly higher rates of pregnancy and clinical pregnancy (64.4% and 57.8%, respectively) than controls (47.4% and 39.3%, respectively). Neonatal birth weight for both singletons and twins was significantly higher in the hCG group (3486 ± 458 g and 2710 ± 437 g, respectively) than in the control group (3195 ± 401 g and 2419 ± 370 g, respectively). Conclusion Pregnancy rate, clinical pregnancy rate, and birth weight were improved in women with endometriosis who underwent intrauterine hCG injection compared with those who did not receive hCG before FET.

Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility

“…Transcription of hCG was found in two-cell-stage embryos ( 14 ), and the specific interaction of blastocyst-derived hCG and the endometrial LH/hCG receptors is a fundamental component in the materno-fetal interface dialogue ( 15 ). It has recently been reported that intrauterine hCG could improve FET outcomes for EM patients ( 10 ). However, intramuscular injection of hCG, in HT regime in EM patients who underwent FET, has never been reported.…”

“…Mohamed et al suggested that the preparation of the endometrium for FET with gonadotropin-releasing-hormone (GnRH) agonists could improve the live birth rate in EM compared with FET ( 9 ). Recently, Xu et al found that pregnancy rate, clinical pregnancy rate, and birth weight were improved in women with EM who underwent intrauterine injection of human chorionic gonadotropin (hCG) before FET ( 10 ). However, these methods are either time-consuming or inconvenient.…”

Effects of human chorionic gonadotropin intrauterine injection on oocyte retrieval day on assisted reproductive techniques outcomes: An RCT

“…HCG injections may be more effective in groups of cases with other infertility problems. Studies can be done on FET cycles as well as on different types of infertility (26).…”

Omics insights into extracellular vesicles in embryo implantation and their therapeutic utility

“…Proteomic [244][245][246] and transcriptomic [247,248] analyses of the cyclic, human endometrium have identified molecular markers of receptivity; recapitulating this receptivity signature in the endometrium prior to ET has thus been a focus for fertility treatments. Embryo-secreted hCG induces endometrial receptivity [249,250] in non-human primates; its intrauterine delivery to prime the endometrium towards an implantative state is thus a promising fertility treatment [251,252] (reviewed [253,254]) and has been explored in clinical trials (NCT01786252 [255], NCT01030393 [256]). Recently, Hajipour et al, engineered human UF-EVs loaded with the known embryonic signal hCG as an intrauterine supplement to increase endometrial receptivity.…”