Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs

“…One study comparing IP and INC bupivacaine revealed lower pain scores with IP bupivacaine during the first hour after surgery and a trend towards a decreased need for rescue analgesia (Campagnol et al. ).…”

Section: Introductionmentioning

confidence: 99%

Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy

Guerrero

Campagna

Bruhl-Day

et al. 2016

Veterinary Anaesthesia and Analgesia

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“…3,[13][14][15][16] Intraperitoneal administration of bupivacaine can reduce pain scores and blunt surgery-induced stress responses in dogs undergoing ovariohysterectomy. [17][18][19] The technique has been recommended by a panel of experts as an adjuvant technique for pain relief in dogs and cats undergoing abdominal surgery. 20 However, to the authors' knowledge, no studies have been conducted on the pharmacokinetics of bupivacaine after IP administration to cats.…”

mentioning

confidence: 99%

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito¹,

Monteiro²,

Beaudry³

et al. 2016

ajvr

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OBJECTIVE To evaluate pharmacokinetics of bupivacaine after IP administration to cats undergoing ovariohysterectomy. ANIMALS 8 healthy cats. PROCEDURES Anesthesia was induced with propofol and maintained with isoflurane. Buprenorphine (0.02 mg/kg, IV) and meloxicam (0.2 mg/kg, SC) were administered. A 20-gauge catheter was inserted into a jugular vein for blood sample collection. A ventral midline incision was made, and a solution of 0.5% bupivacaine (2 mg/kg) diluted with an equal volume of saline (0.9% NaCl) solution (final concentration, 0.25% bupivacaine) was injected into the peritoneal space over the right and left ovarian pedicles and caudal aspect of the uterus before ovariohysterectomy. Cats were monitored for signs of bupivacaine toxicosis. Venous blood samples (2 mL) were collected before (time 0) and 2, 5, 10, 15, 20, 30, 60, 120, and 240 minutes after bupivacaine administration. Plasma bupivacaine concentrations were determined with a liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were determined by data plotting followed by analysis with a noncompartmental model. RESULTS No signs of bupivacaine toxicosis were observed. Maximum bupivacaine plasma concentration was 1,030 ± 497.5 ng/mL at a mean ± SD value of 30 ± 24 minutes after administration. Mean elimination half-life was 4.79 ± 2.7 hours. Mean clearance indexed by bioavailability and volume of distribution indexed by bioavailability were 0.35 ± 0.18 L•h/kg and 2.10 ± 0.84 L/kg, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis. Studies to investigate analgesic effects for this technique in cats are warranted.

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“…Although there was a trend for a decreased need for rescue analgesia in the IP bupivacaine group, this was not significantly different between saline and bupivacaine treatments, most likely due to small sample size and scoring systems used for acute pain assessment (Campagnol et al . ). Based on these findings, the WSAVA‐GPC suggests that the IP route of administration should be given priority over the incisional technique when maximum recommended doses and volumes of local anaesthetics are used, to avoid toxicity.…”

Section: Canine Studiesmentioning

confidence: 97%

“…, Campagnol et al . , Benito et al . , , ), this technique should be readily applied in sterilisation programs, especially in countries with limited drug availability. They should always be performed under strict aseptic conditions and general anaesthesia.…”

Section: Indications For Ip and Incisional Anaesthesiamentioning

confidence: 99%

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

Steagall

Benito

Monteiro

et al. 2019

J of Small Animal Practice

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The World Small Animal Veterinary Association Global Pain Council (WSAVA‐GPC) has recently published its first “capsule review” by Monteiro et al. These are short articles that present a brief assessment of the scientific evidence and practical recommendations on important, and sometimes controversial, subjects in pain management. The capsules will be published regularly in the Journal of Small Animal Practice, the official journal of the WSAVA. This second article discusses the use of intraperitoneal and incisional analgesia in small animal practice, including their limitations and recommendations by the authors.

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Effect of intraperitoneal or incisional bupivacaine on pain and the analgesic requirement after ovariohysterectomy in dogs

Cited by 43 publications

References 4 publications

Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy

Intraperitoneal bupivacaine with or without incisional bupivacaine for postoperative analgesia in dogs undergoing ovariohysterectomy

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Intraperitoneal and incisional analgesia in small animals: simple, cost‐effective techniques

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