Effect of intraoperative magnesium sulphate infusion on pain relief after laparoscopic cholecystectomy

Menteş, Öner; Harlak, Ali; Yigit, T.; Balkan, Ayhan; Balkan, Müjdat; Çoşar, Ahmet; Savaser, A. N.; Kozak, Orhan; Tufan, Turgut

doi:10.1111/j.1399-6576.2008.01816.x

Cited by 70 publications

(56 citation statements)

References 26 publications

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“…We used 50 mg/kg of magnesium sulphate for intraperitoneal instillation. There are various described doses of parenteral use of 50 mg/kg bolus and the continuous infusion till end of surgery, and one report of use of 30 mg/kg of intraperitoneal magnesium sulphate 7,8,9,17,18 . .…”

Section: Discussionmentioning

confidence: 99%

“…Magnesium sulphate as adjunct, parenterally or intraperitoneally improves analgesic effi cacy in postoperative period without any unwanted effects 2,12 . Magnesium sulphate is being used as intravenous bolus and continuous infusion, epidural infusion and in subarachnoid space as well and in most of the studies improved the quality of analgesia with fewer requirements of postoperative analgesics 9,13,14,15 .…”

Section: Discussionmentioning

confidence: 99%

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Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy

Maharjan

Shrestha

2012

J. Kathmandu Med. Coll.

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Background: Multimodal analgesia is necessary for management of pain after laparoscopic cholecystectomy. Magnesium sulphate is a new emerging drug for management of acute pain. This study was performed to study the analgesic effi cacy of intraperitoneal bupivacaine and bupivacaine plus magnesium sulphate for postoperative pain relief after laparoscopic cholecystectomy. Methods: At the end of laparoscopic cholecystectomy, 60 patients were randomized to one of the following groups: bupivacaine group receiving intraperitoneal instillation of 30 ml of 0.25% bupivacaine and magnesium sulphate group receiving intraperitoneal instillation of 0.25% bupivacaine plus 50 mg/kg magnesium sulphate to total volume of 30 ml. Postoperative pain was evaluated by using visual analogue scale (standard Visual Analogue Scale pain score of 0-10). Time duration of fi rst analgesia demanded was noted and rescue analgesic was given as tramadol 50 mg intravenously and on demand. Pain, Visual Analogue Scale score and total analgesic consumption was recorded for 24 hours and analysed. Results: The patients who were given intraperitoneal bupivacaine plus magnesium sulphate at the end of surgery had better pain relief in fi rst 24 hours, Visual Analogue Scale score of 0-5 compared to sole bupivacaine group who had Visual Analogue Scale score of 3-7. The magnesium sulphate group had longer pain free period of average 5.53±4.33 hours after surgery compared to 3.16±1.59 hours in sole bupivacaine group. Total analgesic consumption in magnesium sulphate group was also less compared to bupivacaine group (125.0± 36.5 and 75.0±25.0 in bupivacaine and magnesium sulphate group respectively). All the results show highly signifi cant differences between the groups. Conclusion: The combined instillation of bupivacaine and magnesium sulphate into the peritoneal cavity at the end of laparoscopic surgery renders patients better pain control and less consumption of analgesics in fi rst 24 hours compared to sole bupivacaine group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy

Maharjan

Shrestha

2012

J. Kathmandu Med. Coll.

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“…LC is mainly associated with visceral pain [3] which may refer to the shoulder in 35% to 60% of cases [4,5] . Various treatments have been proposed to make this surgery as pain-free as possible [6][7][8] . The main objective of this study was to assess the effectiveness of implanting fibrin sealant combined with ropivacaine in the gallbladder bed for pain control after LC.…”

Section: Introductionmentioning

confidence: 99%

Effect of implanting fbrin sealant with ropivacaine on painafter laparoscopic cholecystectomy

Fu¹,

Li²,

Yu³

2009

WJG

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AIM:To investigate the safety and efficacy of implanting fibrin sealant with sustained-release ropivacaine in the gallbladder bed for pain after laparoscopic cholecystectomy (LC). METHODS:Sixty patients (American Society of Anesthesiologists physical status was Ⅰ or Ⅱ and underwent LC) were randomly divided into three equal groups: group A (implantation of fibrin sealant in the gallbladder bed), group B (implantation of fibrin sealant carrying ropivacaine in the gallbladder bed), and group C (normal saline in the gallbladder bed). Postoperative pain was evaluated, and pain relief was assessed by visual analog scale (VAS) scoring. RESULTS:The findings showed that 81.7% of patients had visceral pain, 50% experienced parietal, and 26.7% reported shoulder pain after LC. Visceral pain was significantly less in group B patients than in the other groups (P < 0.05), and only one patient in this group experienced shoulder pain. The mean VAS score in group B patients was lower than that in the other groups. CONCLUSION:Visceral pain is prominent after LC and can be effectively controlled by implanting fibrin sealant combined with ropivacaine in the gallbladder bed.

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“…Pada sistem saraf pusat, efek depresi timbul akibat pemberian magnesium yang bertindak sebagai antagonis pada reseptor N-methyl D-aspartat (NMDA) glutamat dan penghambat pelepasan katekolamin. 6,8,9 Magnesium sulfat merupakan penghambat reseptor NMDA, sehingga mencegah sensitisasi sentral akibat stimulasi pada nosiseptif perifer. Magnesium juga memiliki efek antinosiseptif pada hewan serta manusia.…”

Section: Pembahasanunclassified

Pemberian Magnesium Sulfat Intravena Meningkatkan Efek Analgesia Pascaoperasi pada Bedah Mayor Menggunakan Anestesi Umum

Irawan¹,

Subagiartha²,

Widnyana³

2014

jap

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Effect of intraoperative magnesium sulphate infusion on pain relief after laparoscopic cholecystectomy

Abstract: Per-operative 50 mg/kg magnesium sulphate infusion is effective in reducing post-operative pain in patients undergoing LC.

Cited by 70 publications

References 26 publications

Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy

Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy

Effect of implanting fbrin sealant with ropivacaine on painafter laparoscopic cholecystectomy

Pemberian Magnesium Sulfat Intravena Meningkatkan Efek Analgesia Pascaoperasi pada Bedah Mayor Menggunakan Anestesi Umum

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