Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy

Bhatia, Anuj; Kashyap, Lokesh; Pawar, Dilip; Trikha, Anjan

doi:10.1016/j.jclinane.2003.08.012

Cited by 87 publications

(63 citation statements)

References 13 publications

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“…They found that patients in both groups had similar pain scores and morphine requirement during the first 24 h postoperatively [15]. Also the results of the present study best correlate with the findings of Seong-Hoon et al, who studied the effect of intravenous magnesium sulfate infusion (preoperative loading dose of 50 mg/kg followed by 15 mg/kg/h continuous infusion for 6 h) versus placebo on the postoperative pain in patients undergoing abdominal hysterectomy under general anesthesia.…”

Section: Discussionsupporting

confidence: 89%

Comparison of the preemptive analgesia of low dose ketamine versus magnesium sulfate on parturient undergoing cesarean section under general anesthesia

Helmy

Badawy

Hussein

et al. 2015

Egyptian Journal of Anaesthesia

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Objective: To investigate the efficacy of the preemptive analgesic effect of low dose ketamine versus MgSO 4 on potentiating postoperative analgesia when compared to placebo in patients undergoing cesarean section under general anesthesia. Methods: This prospective randomized blind study included 60 parturient females scheduled for cesarean section under general anesthesia. They were randomized into three equal groups [20 patients each]: group I [Control]: received 20 ml normal saline 0.9%, group II [Ketamine]: received ketamine 0.3 mg/kg in 20 ml normal saline and group III [MgSO 4 ]: received MgSO 4 , 30 mg/kg in 20 ml normal saline. Investigated medications infused over 10 min before induction of anesthesia.Fentanyl requirement, mean BP and HR were measured intraoperatively. Pain, sedation and nausea and vomiting were assessed at 2, 6, 12 and 24 h postoperatively. Total postoperative pethidine dose over 24 h was calculated. Results: MBP and HR showed statistically significantly lower value in group (K) and (M) compared to group (C) at postintubation and postincision readings. Intraoperative fentanyl requirement was statistically higher in (C) groups compared to (K) and (M) groups. The time for first request for postoperative analgesia was longer and the total postoperative pethidine dose over 24 h was lower in (K) group compared to (C) and (M) groups. Postoperative VAS scores at 2 and 6 h postoperatively showed statistically highly significantly lower values in (K) group compared to (C) and (M) groups. Apgar, postoperative sedation and PONV scores showed no statistically significant differences among the three groups. Conclusions: Preemptive dose of either ketamine (0.3 mg/kg) or MgSO 4 (30 mg/kg) in patients undergoing cesarean section under general anesthesia could suppress the pressor response to endotracheal intubation and skin incision and decreased the intraoperative fentanyl requirement. Ketamine showed a significant preemptive analgesic effect compared to MgSO 4 at 2 and 6 h postoperatively.

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Section: Discussionsupporting

confidence: 89%

Comparison of the preemptive analgesia of low dose ketamine versus magnesium sulfate on parturient undergoing cesarean section under general anesthesia

Helmy

Badawy

Hussein

et al. 2015

Egyptian Journal of Anaesthesia

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“…The study done by Gupta et al 4 and various other authors describe about the sedation they have acquired from the utilization of Magnesium sulphate and similarly in our study we have also obtained a better sedation profile compared to the control group. Patients in the control groups had more analgesic requirement during the first 24 hours postoperatively, while patients in the Magnesium group had less discomfort during the first 24 hours after the operation.…”

Section: Discussionsupporting

confidence: 86%

Effect of Preoperative Magnesium Infusion on Postoperative Pain in Patients Under General Anaesthesia

Nidhin¹,

Abraham²

2016

jemds

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Despite the availability of newer clinical practice objectives, effective analgesics and new technologies for pain measurement, the management of postoperative pain continues to remain a problem. Patients have the right to be recognized as experts of their own pain experience and to have their pain report reflected accurately in the type of pain relief they receive. They also have the right to expect that relief of their pain be considered to be a reasonable goal of the treatment. With the increasing understanding of pain physiology and the (N-Methyl D Aspartate) NMDA receptor, the use of Magnesium for secondary analgesia and as an adjuvant to different regimens is introducing newer possibilities for the use of Magnesium in acute and chronic pain. The popularity of Magnesium sulphate in wide spectrum of clinical application also finds its use in attenuating postoperative pain. In our study, we will be assessing the patients while they are undergoing surgery and their postoperative pain scores when the patient is premedicated with Magnesium sulphate. MATERIALS AND METHODS60 patients undergoing general surgery were randomly divided into 2 groups of 30 each. The Magnesium sulphate group received 50mg/kg in 100mL of normal saline solution over 30 minutes before the surgery intravenously, whereas control group received same volume of normal saline solution over 30 minutes preoperatively. RESULTSData collected was subjected to standard statistical analysis and analysed using Chi-square test. There was significant difference in the pain scores after the injection of Magnesium sulphate between both the groups. CONCLUSIONWe found out that majority of patients find relief, while a minority of patients had the issue of nausea and vomiting. We conclude that Magnesium sulphate provides a good pain relief without any significant adverse effects.

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“…Magnesium sulphate as adjunct, parenterally or intraperitoneally improves analgesic effi cacy in postoperative period without any unwanted effects 2,12 . Magnesium sulphate is being used as intravenous bolus and continuous infusion, epidural infusion and in subarachnoid space as well and in most of the studies improved the quality of analgesia with fewer requirements of postoperative analgesics 9,13,14,15 .…”

Section: Discussionmentioning

confidence: 99%

Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy

Maharjan

Shrestha

2012

J. Kathmandu Med. Coll.

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Background: Multimodal analgesia is necessary for management of pain after laparoscopic cholecystectomy. Magnesium sulphate is a new emerging drug for management of acute pain. This study was performed to study the analgesic effi cacy of intraperitoneal bupivacaine and bupivacaine plus magnesium sulphate for postoperative pain relief after laparoscopic cholecystectomy. Methods: At the end of laparoscopic cholecystectomy, 60 patients were randomized to one of the following groups: bupivacaine group receiving intraperitoneal instillation of 30 ml of 0.25% bupivacaine and magnesium sulphate group receiving intraperitoneal instillation of 0.25% bupivacaine plus 50 mg/kg magnesium sulphate to total volume of 30 ml. Postoperative pain was evaluated by using visual analogue scale (standard Visual Analogue Scale pain score of 0-10). Time duration of fi rst analgesia demanded was noted and rescue analgesic was given as tramadol 50 mg intravenously and on demand. Pain, Visual Analogue Scale score and total analgesic consumption was recorded for 24 hours and analysed. Results: The patients who were given intraperitoneal bupivacaine plus magnesium sulphate at the end of surgery had better pain relief in fi rst 24 hours, Visual Analogue Scale score of 0-5 compared to sole bupivacaine group who had Visual Analogue Scale score of 3-7. The magnesium sulphate group had longer pain free period of average 5.53±4.33 hours after surgery compared to 3.16±1.59 hours in sole bupivacaine group. Total analgesic consumption in magnesium sulphate group was also less compared to bupivacaine group (125.0± 36.5 and 75.0±25.0 in bupivacaine and magnesium sulphate group respectively). All the results show highly signifi cant differences between the groups. Conclusion: The combined instillation of bupivacaine and magnesium sulphate into the peritoneal cavity at the end of laparoscopic surgery renders patients better pain control and less consumption of analgesics in fi rst 24 hours compared to sole bupivacaine group.

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Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy

Cited by 87 publications

References 13 publications

Comparison of the preemptive analgesia of low dose ketamine versus magnesium sulfate on parturient undergoing cesarean section under general anesthesia

Comparison of the preemptive analgesia of low dose ketamine versus magnesium sulfate on parturient undergoing cesarean section under general anesthesia

Effect of Preoperative Magnesium Infusion on Postoperative Pain in Patients Under General Anaesthesia

Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy

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