Effect of Intraoperative Low-dose Dopamine on Renal Function in Liver Transplant Recipients

Swygert, Thomas H.; Roberts, Larry; Valek, T. R.; Brajtbord, D.; Brown, M. R.; Gunning, Thomas C.; Paulsen, A. W.; Ramsay, Michael A. E.

doi:10.1097/00000542-199110000-00005

Cited by 95 publications

(34 citation statements)

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“…Even the short-term effects of LDD were not confirmed by the present study, in which no differences in creatinine clearance were found. Corroborating our results, other authors have also shown that renal function is not improved with LDD for patients undergoing cardiac surgery 16 or liver transplantation, 17 or for those in postoperative states, 15,16,31 critically ill with oliguria, 13 or with previous renal diseases. 14 Other recent studies have confirmed these findings.…”

Section: Discussionsupporting

confidence: 87%

“…2 This matter continues to be controversial, since other authors have failed to detect this effect. 4,9,17,40 In the present investigation the increase in FENa + (30%) was not considered significant.…”

Section: Referencesmentioning

confidence: 61%

“…With LDD infusion, the patients in the present study showed a significant increase in diuresis, of 48%, which corroborates the findings of other researchers. 12,17,27,[34][35][36][37] Although some of these authors argue that a significant increase in diuresis after LDD infusion could protected the kidney, for instance against the hazardous effects of crossclamping of the aorta, 35 there is no strong evidence that this really occurs. Nonetheless, despite the increased diuresis, our patients did not have a corresponding increase in CLcr.…”

Section: Referencesmentioning

confidence: 99%

“…3,6,[8][9][10][11] Studies with animals 12 and acute renal failure patients 8,9,[13][14][15][16][17] have not shown evidence that LDD maintained or improved renal function. Thus, if proven inadequate, continued injection of LDD would result only in potential additional medical treatment, 18 thereby increasing the costs.…”

Section: Introductionmentioning

confidence: 99%

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Hemodynamics and renal function during administration of low-dose dopamine in severely ill patients

et al. 2004

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CONTEXT: Although a large number of studies have been performed regarding the renal and hemodynamic effects of the infusion of low-dose dopamine (LDD) in severely ill patients, there is still controversy on this subject. OBJECTIVE: To evaluate the effects of dopamine (2 mug/kg/min) on systemic hemodynamics (lowest mean arterial pressure, MAP, highest heart rate, HR, central venous pressure, CVP), creatinine clearance (CLcr), diuresis and fractional sodium excretion (FENa+). TYPE OF STUDY: A non-randomized, open, prospective clinical trial. SETTING: An intensive care unit in a tertiary university hospital. PARTICIPANTS: 22 patients with hemodynamic stability admitted to the intensive care unit. PROCEDURES: Patients were submitted to three two-hour periods: without dopamine (P1), with dopamine (P2) and without dopamine (P3). MAIN MEASUREMENTS: The abovementioned variables were measured during each period. CLcr was assessed based upon the formula U x V/P, where U is urinary creatinine (mg/dl), V is diuresis in ml/min and P is serum creatinine (mg/dl). FENa+ was calculated based upon the formula: urinary sodium (mEq/l) x P/plasma sodium (mEq/l) x U) x 100. Results were presented as mean and standard deviation. The Student t test was used and results were considered significant if p was less than 0.05. RESULTS: Twelve patients (seven males and five females) were included, with a mean age of 55.45 years. There was no significant variation in MAP, HR, CVP, CLcr or FENa+ with a dopamine dose of 2 mug/kg/min. On the other hand, diuresis significantly increased during P2, from 225.4 to 333.9 ml. CONCLUSION: Infusion of 2 mug/kg/min of dopamine for 2 hours increases diuresis. At the doses studied, dopamine does not induce significant alterations in MAP, HR, CVP, CLcr and FENa+.

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Section: Discussionsupporting

confidence: 87%

Section: Referencesmentioning

confidence: 61%

Section: Referencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemodynamics and renal function during administration of low-dose dopamine in severely ill patients

et al. 2004

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“…6 Because of its specific renal effects, low-dose dopamine has been used to treat cases of suspected renal hypoperfusion and vasoconstriction, 2 factors involved in renal dysfunction and acute tubular necrosis. [7][8][9][10][11][12][13] Vasoconstriction after ischemiareperfusion in kidney transplant has been proposed to explain posttransplant kidney dysfunction. 14 Although infusion of a "renal dopamine dose" has been suggested to provide better renal tissue perfusion and better preservation of transplant function, so far, there is no clinical evidence either for or against this strategy.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Bataille

Payen²,

Villiers³

et al. 2016

Exp Clin Transplant

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Objectives: The relation between dopamine infusion and renal hemodynamics and function has not been studied in renal allografts during early recovery. We analyzed the dose response of dopamine infusion on renal blood flow and function in human kidney transplant recipients at reperfusion and during early graft recovery. Conclusions: Immediately after transplant, kidney grafts with ischemic-reperfusion injury are fully dilated and do not respond to dopamine. The specific renal effects observed are due to systemic hemodynamic status. Vascular responsiveness to a "renal dopamine dose" returns on graft recovery.

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Donor Dopamine Pretreatment and Graft Function After Kidney Transplantation

Ball¹,

McAnulty²

2010

JAMA

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Effect of Intraoperative Low-dose Dopamine on Renal Function in Liver Transplant Recipients

Cited by 95 publications

References 0 publications

Hemodynamics and renal function during administration of low-dose dopamine in severely ill patients

Hemodynamics and renal function during administration of low-dose dopamine in severely ill patients

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Donor Dopamine Pretreatment and Graft Function After Kidney Transplantation

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