Effect of intraocular pressure control on central corneal thickness, horizontal corneal diameter, and axial length in primary congenital glaucoma

Cronemberger, Sebastião; Calixto, Nassim; Milhomens, Thiago Gutemberg Avellar; Gama, Priscila Ottoni; Milhomens, Eduardo Gutemberg; Rolim, Hévila; Mendonça, Swethlana Calheiros

doi:10.1016/j.jaapos.2014.05.012

Cited by 30 publications

(37 citation statements)

References 5 publications

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“…The cornea was thicker in patients with poor IOP control awaiting surgery. In agreement with Cronemberger et al [17], this indicates that increased central corneal thickness is likely to be associated with decompensated pressure and need for further treatment.…”

Section: Discussionsupporting

confidence: 90%

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Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography

Pilat

Proudlock

Shah

et al. 2019

Eye

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Purpose To investigate the potential of handheld optical coherence tomography (HH-OCT) in assessing the anterior segment of the eye in patients with primary congenital glaucoma. Design A prospective, case-controlled observational study. Participants Twenty-two patients with primary congenital glaucoma (PCG, 9 females and 13 males; mean age 4.36 ± 3.4 years) and age-, gender-and ethnicity-matched healthy participants. Methods Anterior OCT was performed in all participants using a high-resolution HH SD-OCT device (Envisu 2300, Leica Microsystems, Germany) without anaesthesia or sedation. Results Anterior HH-OCT in PCG visualised Haab's striae in 14.3%, uneven internal cornea in 9.5% and epithelial thickening in 11.9% of patients with central corneal thickening (CCT, p < 0.001). CCT was significantly correlated with the intraocular pressure (IOP, p < 0.001). The flat iris with a thin collarette zone was found in 59.5%, anterior iris insertion in 11.90% of eyes affected by PCG. Two independent examiners showed sensitivity and specificity of 87% and 77%, respectively, by instating iris thinning and flattening of the anterior profile. Conclusions Anterior HH-OCT has significant potential to improve diagnosis and management of PCG. Clinically relevant information can be obtained non-invasively and without sedation. High specificity makes anterior HH-OCT an important adjunct for management of PCG. Excellent visualisation of the iris insertion on OCT indicates potential for AS OCT to assist with surgical planning, including decision on the type of surgery and location of the incision.

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Section: Discussionsupporting

confidence: 90%

“…Thickening of the cornea was found in several other studies using pachimetry [17][18][19] and UBM [20]. In our PCG patients, central corneal thickness was also significantly increased with a positive correlation with increased IOP.…”

Section: Discussionsupporting

confidence: 83%

Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography

Pilat

Proudlock

Shah

et al. 2019

Eye

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“…Primary trabeculectomy was performed between the age of 7 days and 12 months in all eyes from both groups. Our results do not confirm poor prognosis associated with younger age at diagnosis or surgery in PCG patient and the outcomes are similar to results of other surgeons (2,3,5,8).…”

Section: Discussioncontrasting

confidence: 50%

“…Various authors consider axial length and corneal diameter to be important factors in diagnosis and monitoring of patients with PCG (5,8). In our study, there was no difference in baseline axial length and corneal diameter between the groups.…”

Section: Discussionmentioning

confidence: 42%

Evaluation of functional and morphological parameters in eyes with primary congenital glaucoma after trabeculectomy in the long-term follow-up

Koraszewská-Matuszewska¹,

Nita²,

Grzybowski³

2018

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Aim: Primary congenital glaucoma is the most prevalent type of primary paediatric glaucoma. The aim of the study was to estimate functional and morphological parameters in eyes with primary congenital glaucoma, with and without Haab's striae, after classic trabeculectomy in the long-term follow-up. Material and methods: 41 eyes of 27 children aged 7 days to 12 months at primary trabeculectomy with (group I) and without Haab's striae (group II) were reviewed. The best corrected visual acuity, intraocular pressure, central corneal thickness, axial biometry, corneal horizontal diameter, refraction, central endothelial cell density, cup-to-disc ratio, and perimetric mean deviation were analysed. Results: The mean follow-up was 11.4 years. The mean age of operated infants was 5.65 months (group I) and 4.41 months (group II). The mean intraocular pressure before trabeculectomy was significantly higher and endothelial cell density was significantly lower in group I than in group II. The mean myopic refractive error was significantly higher in group I than in group II. There was no difference in best corrected visual acuity, central corneal thickness, axial biometry, corneal horizontal diameter, and perimetric mean deviation between the two groups. Conclusions: The visual function in patients with primary congenital glaucoma after successful trabeculectomy performed in infancy is satisfactory, despite the presence of Haab's striae, impaired corneal structure and decreased endothelial cell density. High intraocular pressure before treatment is an important risk factor for the development of Haab's striae. Classic trabeculectomy is a good first-line surgical procedure in the treatment of primary congenital glaucoma with and without Haab's striae.

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“…; Cronemberger et al. ). PCG is usually associated with elevated IOP at early age in which the ocular parts are not fully mature and have more plasticity.…”

Section: Discussionmentioning

confidence: 98%

Corneal profile in primary congenital glaucoma

Doozandeh

Yazdani

Ansari

et al. 2017

Acta Ophthalmologica

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Effect of intraocular pressure control on central corneal thickness, horizontal corneal diameter, and axial length in primary congenital glaucoma

Cited by 30 publications

References 5 publications

Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography

Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography

Evaluation of functional and morphological parameters in eyes with primary congenital glaucoma after trabeculectomy in the long-term follow-up

Corneal profile in primary congenital glaucoma

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