Effect of Intranasal Dexamethasone on the Incidence of Nausea and Vomiting After Adult Strabismus Surgery

Shetabi, Hamidreza; Koohi, Hadi

doi:10.5812/aapm-130452

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Therefore, the use of IN dexamethasone can be considered as a non-invasive method to control systemic in ammation or prevent subsequent nausea and vomiting [15][16][17]. The nasal mucosa is a large, vascular pathway that transports substances directly to the brain through the olfactory nerve sheath, aiding systemic absorption and allowing rapid onset of action.…”

Section: Introductionmentioning

confidence: 99%

The prophylactic effect of intranasal Dexamethasone in reducing postoperative sore throat. A novel clinical trial.

Shetabi

Momeni

2023

Preprint

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Background: Sore throat is the most common complication of tracheal intubation and is an unpleasant complication in patients who undergo general anesthesia with tracheal intubation. Considering the importance of reducing the incidence of postoperative sore throat (POST) and increasing patient satisfaction, in this study we discussed the effectiveness of intranasal dexamethasone in reducing the incidence of POST in patients under general anesthesia. Methods: This double-blind randomized clinical trial study was carried out on 96 patients over 18 years of age who were candidates for elective eye surgery from July 2019 to March 2020 at Faiz Hospital in Isfahan. The patients were divided randomly into two groups of 48 to receive intranasal Dexamethasone (IND) or intranasal normal saline (INS), administration of drugs was immediately after endotracheal intubation. Demographic data, the presence of sore throat, cough, and hoarseness during the stay in the recovery as well as in the ward (up to 24 hours) were recorded and analyzed by SPSS software version 23. Results: The results of the current study showed that percentage of sore throat, cough and hoarseness during the stay in the recovery room and 2 hours after entering the ward in the IND group was significantly lower than the INS group (P value<0.001). but at 6, 12, and 24 hours after the stay in Ward, despite the lower frequency of these symptoms in the IND group compared to the INS group, there was no significant difference between the two groups (P value>0.05). Discussion: This is an innovative clinical trial that evaluate the prophylactic effect of intranasal Dexamethasone in reducing postoperative sore throat. This research shows that intranasal administration of dexamethasone can reduce post-operative sore throat, hoarseness, cough and improve the quality of stay in the recovery room. The trial was registered with the identification number IRCT20180416039326N7 (date: 31/5/2019) in the Clinical Trials Registration Center of Iran.

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Section: Introductionmentioning

confidence: 99%

The prophylactic effect of intranasal Dexamethasone in reducing postoperative sore throat. A novel clinical trial.

Shetabi

Momeni

2023

Preprint

Self Cite

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Is intranasal dexamethasone effective in reducing sore throat following surgery?

Shetabi,

Momeni

2024

Tzu Chi Medical Journal

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Objectives: Postextubation, individuals may experience the discomfort of a sore throat. Our main aim of the study was to investigate if intranasal dexamethasone is successful in reducing postoperative sore throat occurrence. Materials and Methods: The study involved 96 adult individuals who were scheduled for elective eye surgery at Faiz Medical Center, which is affiliated with Isfahan University, between July 2020 and March 2021. The individuals were assigned by chance to two cohorts of 48 people each, with one cohort getting dexamethasone (IND) through the nose and the other cohort getting normal saline (INS) through the nose right after the endotracheal tube insertion. The presence of symptoms such as aching throat, cough, and hoarseness after surgery was recorded and examined with version 23 of the SPSS software. Results: Upon analysis, it was observed that there were no statistically significant alterations in demographic attributes, tracheal intubation variables, duration of surgery, and postoperative outcomes (P < 0.05). Within the IND cohort, a notable 80.2% decrease in the occurrence of sore throat was noted immediately following the surgical procedure, along with a 34% reduction within the initial 6 hours of hospital stay (P < 0.001). Moreover, dexamethasone also decreased the occurrence of cough and hoarseness by 31.7% and 38.2% during recovery, as well as 19% and 25.4% within the initial 2 h upon admission to the ward (P < 0.001). Conclusion: The current study showcased the preventive impact of dexamethasone intranasally in decreasing the occurrence of sore throat in the early stages of postoperative period. Nevertheless, its efficacy diminished after 6 h. Furthermore, the intranasal application of dexamethasone exhibited the ability to alleviate hoarseness and cough within the first 2 h following surgical intervention.

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Effect of Intranasal Dexamethasone on the Incidence of Nausea and Vomiting After Adult Strabismus Surgery

Cited by 2 publications

References 15 publications

The prophylactic effect of intranasal Dexamethasone in reducing postoperative sore throat. A novel clinical trial.

The prophylactic effect of intranasal Dexamethasone in reducing postoperative sore throat. A novel clinical trial.

Is intranasal dexamethasone effective in reducing sore throat following surgery?

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