Effect of intralesional platelet rich plasma in chronic localized vitiligo

Abstract

<p class="abstract"><strong>Background:</strong> Vitiligo is a disease caused by destruction of melanocytes in lesional skin. It occurs worldwide in occurance of 0.1 to 2.0 percent. It is a multifactorial polygenic disease with complex pathogenesis. Several treatments, old and new are advocated for such patients. The first line of treatment includes topical corticosteroids and calcineurin inhibitors, and phototherapy (NBUVB, PUVA). The second line of treatment includes systemic corticosteroids, topical calcipotriol 0.005%, lasers such as excimer laser (308 nm). The aim of the study was to evaluate the efficacy of platelet rich plasma in 40 cases of stable vitiligo with less than or equal to 1% body surface area involvement.</p><p class="abstract"><strong>Methods:</strong> 40 cases of stable vitiligo not responding to adequate topical therapy for more than 1 year were included in the study. They were subjected to intralesional injections of freshly prepared autologous platelet rich plasma (PRP) by double spin technique. Each patient was given injections every 2 weekly interwals for a total of 6 injections. Results were evaluated using the vitiligo area severity index (VASI) score.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 40 patients15 Patients showed good response, 12 patients showed Average response and13 patients showed no response to treatment according to VASI score.</p><p class="abstract"><strong>Conclusions:</strong> PRP may be considered as an additional therapy in patients not responding adequately to traditional therapies. Our patients were not subjected to histopathology. It was also felt that patients might require more than 6 sittings for complete repigmentation.</p>

Evaluation of combined excimer laser and platelet‐rich plasma for the treatment of nonsegmental vitiligo: A prospective comparative study

“…It was also discovered that PRP therapy can induce and accelerate fibroblast proliferation and migration by up‐regulating cyclin E‐ and cyclin‐dependent kinase 4, which is essential in cell migration and proliferation …”

“…27 It was also discovered that PRP therapy can induce and accelerate fibroblast proliferation and migration by up-regulating cyclin E-and cyclin-dependent kinase 4, which is essential in cell migration and proliferation. 12,13 In this research, the use of PRP was to increase the excimer laser impact and shorten the therapy length. This research showed that combining intradermal PRP injection with the excimer laser is a promising vitiligo therapy that can generate a substantial enhancement in stable, nonsegmental vitiligo in various body locations with minimal side effects and in a brief period of time.…”

“…The PRP has accomplished tremendous outcomes in the therapy of vitiligo, particularly for repigmentation and patient satisfaction . This research was therefore intended to assess the result of mixing PRP and excimer laser in vitiligo therapy.…”

Fractional carbon dioxide laser versus fractional carbon dioxide laser with autologous intralesional platelet-rich plasma in the treatment of stable, non-segmental vitiligo: A randomized comparative study

“…Females outnumbering males in our study are in concordance to previous studies. [ 4 6 7 8 ] Increased social consequences in girls and women affected by vitiligo make them seek medical attention more than males. [ 9 ]…”

“…PRP could also increase the interaction of melanocytes with keratinocytes and stabilize the melanocytes. [ 6 ]…”