Effect of intrajejunal elemental diet perfusion on jejunal secretion of immunoglobulins, albumin, and hyaluronan in man.

Colombel, J F; Vaerman, Jp.; Hällgren, Roger; Dehennin, Jean-Pierre; Wain, E.; Modigliani, R; Cortot, Antoine

doi:10.1136/gut.33.1.44

Cited by 6 publications

(3 citation statements)

References 11 publications

(1 reference statement)

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“…In conclusion, this and our previous studies suggest that ED perfusions have the capacity to modulate both cellular and humoral intestinal immune responses [13]. The raised jejunal perfusate levels of sCD8 induced by the perfusion of an ED solution may reflect a physiological activation of suppressive cellular immunity.…”

Section: Discussionsupporting

confidence: 65%

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Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

Desreumaux

Levy

Vaerman

et al. 1996

Clinical and Experimental Immunology

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SUMMARYThe effects of nutrients on the mucosal immune system are poorly understood. The aim of this work was to study the cellular mucosal immune response to intrajejunal perfusion of an elemental diet (ED) or a control (C) electrolyte solution by measuring jejunal secretion of soluble CD4 (sCD4) and sCD8. sCD4 and sCD8 are markers of helper/inducer and suppressor/cytotoxic regulatory functions of T cells, respectively. A four lumen tube with a proximal occluding balloon at the angle of Treitz was used for jejunal perfusion in seven healthy volunteers (mean age 23 years). The length of the test segment was 40 cm. The jejunum was successively perfused with C for 80 min and then with ED containing 21 . 3 g/l of free amino acids and 104 . 2 g/l of oligosaccharides for 100 min. Jejunal fluid and serum concentrations of sCD4 and sCD8 were measured and their jejunal outputs calculated. When compared with C perfusion, jejunal perfusion with the ED resulted in a significant increase of sCD8 but not sCD4 jejunal secretion rates. sCD8 jejunal values increased early after ED perfusion and stayed at roughly the same level during the perfusion. Serum concentrations of sCD4 and sCD8 were not modified during ED perfusion. These data support the hypothesis that ED suppresses the immunologic tone of the gut, which could explain its beneficial effect in the management of intestinal inflammatory disease.

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Section: Discussionsupporting

confidence: 65%

“…In our study, an immunological mechanism in response to carbohydrate may be involved, since ED solution contains no peptide. Such a mechanism of intestinal T cell activation could also explain the significant increase of intestinal IgA secretion previously observed during the perfusion of a similar ED [13].…”

Section: Discussionmentioning

confidence: 69%

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

Desreumaux

Levy

Vaerman

et al. 1996

Clinical and Experimental Immunology

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“…[7][8][9][10] The mucosa receives much of its nutrition directly from the lumen and substrates such as glutamine and short chain fatty acids have been shown to be the preferred fuels for the enterocytes and colonocytes, respectively. 11,12 Glutamine supplemented elemental diets have been shown to have beneficial effects in terms of intestinal mucosal morphology and bacterial translocation following radiotherapy.…”

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confidence: 99%

Naso-jejunal feeding in allogeneic bone marrow transplant recipients: results of a pilot study

Sefcick

Anderton

Byrne

et al. 2001

Bone Marrow Transplant

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Summary:Patients undergoing allogeneic bone marrow transplants (BMT) are often malnourished prior to commencing the procedure. They face intensive treatment with often marked nutritional consequences. There is no consensus on the optimal nutritional management of these patients. Elective parenteral nutrition (PN), beginning pre-transplant irrespective of the patients nutritional status, or the use of 'salvage' PN, beginning during the post-transplant period if the patient fails to maintain nutritional status with oral diet, have been used. Enteral nutrition may benefit the patient by maintaining nutritional support throughout the transplant period, avoiding the complications and expense of PN and possibly, by using specific diets, protecting the gastrointestinal tract from the effects of chemoradiation. However, naso-gastric feeding during a transplant is not without risks, including the safe insertion of a tube in patients with mucositis and pan-cytopenias, tube displacement by vomiting and aspiration from gastro-oesophageal reflux. An alternative approach is to use nasojejunal (NJ) feeding tubes which are associated with less risk of loss due to vomiting and less risk of aspiration. We report a pilot study of 15 allogeneic BMT patients who had elective NJ feeding initiated before conditioning therapy irrespective of perceived nutritional compromise. This was well tolerated and feasible with a motivated nutritional team. Bone Marrow Transplantation (2001) 28, 1135-1139. Keywords: allogeneic bone marrow transplant; enteral feeding; naso-jejunal feeding tubes; pilot study Patients undergoing BMT are often under-nourished due to previous chemotherapy and the underlying disease process. They face a long hospital stay and intensive conditioning therapy, which can have marked nutritional consequences. Subsequent complications such as infections, veno-occlus-

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Pharmacokinetics of an indium-labeled IgG monoclonal antibody over a prolonged period

Halpern

Bartholomew²

1995

Eur J Nucl Med

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This study was directed toward determining the pharmacokinetic fate of an IgG2a monoclonal antibody (MoAb). The 96.5 anti-melanoma MoAb was labeled with indium-111 and indium-114m and administered to BALB/c mice. The mice receiving 111In MoAb were sacrificed at 4 and 72 h, while those receiving 114mIn 96.5 MoAb (50-day physical half-life) were sacrificed at 4 h and 3, 15, and 30 days. Multiple tissues were counted against a standard of the injectate and the data expressed as percent injected dose per organ and percent total dose excreted in the urine and feces. The 111In- and 114mIn-labeled MoAbs had nearly identical distribution through 72 h. Over the 30-day period 25% of the 114mIn label was excreted in the urine and 50% eliminated in the feces. All of the tissues studied showed a decrease in 114mIn in the 30-day period. We conclude that the metabolic products of indium-labeled MoAbs, the indium itself, or a combination of both are eliminated from the tissues over a period of several weeks and do not accumulate to a significant extent in any single site.

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Effect of intrajejunal elemental diet perfusion on jejunal secretion of immunoglobulins, albumin, and hyaluronan in man.

Cited by 6 publications

References 11 publications

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

Effect of intrajejunal elemental diet perfusion on local secretion of soluble CD4 and CD8

Naso-jejunal feeding in allogeneic bone marrow transplant recipients: results of a pilot study

Pharmacokinetics of an indium-labeled IgG monoclonal antibody over a prolonged period

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