Effect of Intragastric Balloons on Liver Enzymes: A Systematic Review and Meta-Analysis

Abstract

The use of intragastric balloon decreases liver enzymes and is potentially an effective short-term treatment for NAFLD as part of a multidisciplinary approach. Larger, more rigorous trials are needed to confirm the effect of IGBs on NAFLD.

Treatment of Nonalcoholic Fatty Liver Disease: The Role of Medical, Surgical, and Endoscopic Weight Loss

“… 78 Intragastric balloons (IGB) have been shown to decrease liver enzymes and improve liver histology. 79 , 80 Histological response to IGB therapy was evaluated in a single-blinded randomized controlled trial. 80 The control arm received dietary intervention and sham endoscopy.…”

Real Life Changes in Physical Activity Due to Intragastric Balloon Therapy and Their Relationship to Improving Cognitive Functions: Preliminary Findings

“…Endoscopic insertion of the intragastric balloon (IGB) is a minimally invasive procedure leading to premature satiation, prolonged satiety, and influences the hormone levels regulating energy balance [1][2][3][4][5][6][7] The weight reductions induced by IGB are retained by a relatively low number of patients over longer periods after its removal [1,[8][9][10]. As physical activity (PA) plays an important role in promoting long-term weight maintenance [11], we have evaluated changes in PA accompanying IGB treatment.…”

Gastric space-occupying devices for management of obesity and metabolic disease

“…In time, robust data supporting the use of this liquid-filled 6month indwelling balloon was created. Several meta-analyses have shown its efficacy and safety against placebo treatment [26], against diet alone [27], to treat severe obesity [28], to address obesity-related comorbidities [29] and nonalcoholic steatohepatitis [30]. Long-term data are slightly more limited, but a few studies with 5-year followup have already demonstrated some weight loss maintenance after the IGB removal [31,32].…”