Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man

Riepl, Rudolf L.; Lehnert, Peter; Scharl, A.; Hempen, I.; Fiedler, Fritz; Teufel, J; Burhol, P. G.

doi:10.3109/00365529008999208

Cited by 33 publications

(24 citation statements)

References 34 publications

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“…In contrast, the dihydroxy bile salt Na-taurodeoxycholate dose-dependently (0.38 to 1.14 mmol) enhanced basal (24) and secretin-stimulated (11) volume, bicarbonate, and enzyme secretion. The effect was related to the load, not to the concentration of this bile salt (11).…”

Section: Effect Of Bile and Bile Salts On Basal And Hormonally Stimulmentioning

confidence: 88%

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl¹,

Lehnert²

1992

Scandinavian Journal of Gastroenterology

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Section: Effect Of Bile and Bile Salts On Basal And Hormonally Stimulmentioning

confidence: 88%

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Riepl¹,

Lehnert²

1992

Scandinavian Journal of Gastroenterology

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“…The blood samples for the determination of plasma glucagon according to Heding (1979), and eatecholam/nes according to Passon and Peuler (1973) and Peuler and Iohnson (1977) were transferred into prechiUed tubes with the appropriate ingredients quickly centrifuged at 4~ and stored at -70~ Growth hormone (yon Werder 1975), prolactin (yon Werder 1975, and cortisol (Stalla et al 1981) determinations were measured by standard analytical procedures. Pancreatic polypeptide was determined by radioimmunoassay according to Riepl et al (1990).…”

Section: Methodsmentioning

confidence: 99%

Metabolic and hormonal studies of Type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation

Landgraf¹,

Nusser²,

Riepl³

et al. 1991

Diabetologia

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Summary. Long-term normalization of glucose metabolism is necessary to prevent or ameliorate diabetic complications. Although pancreatic grafting is able to restore normal blood glucose and glycated haemoglobin, the degree of normalization of the deranged diabetic metabolism after pancreas transplantation is still questionable. Consequently glucose, insulin, C-peptide, glucagon, and pancreatic polypeptide responses to oral glucose and i.v. arginine were measured in 36 Type 1 (insulin-dependen0 diabetic recipients of pancreas and kidney aUografts and compared to ten healthy control subjects. Despite normal HbA1 (7.2_+0.2%; normal <8%) glucose disposal was norreal only in 44% and impaired in 56% of the graft recipients, Normalization of glucose tolerance was achieved at the expense of hyperinsulinaemia in 52% of the subjects. C-peptide and glucagon were normal, while pancreatic polypeptide was significantly higher in the graft recipients, Intravenous glucose tolerance (n=21) was normal in 67% and borderline in 23%. Biphasic insulin release was seen in patients with normal glucose tolerance. Glucose tolerance did not deteriorate up to 7 years post-transplant. In addition, stress hormone release (cortisol, growth hormone, prolactin, glucagon, catecholamines) to insulininduced hypoglycaemia was examined in 20 graft recipients and compared to eight healthy subjects. Reduced blood glucose decline indicates insulin resistance, but glucose recovery was normal, despite markedly reduced catecholamine and glucagon release. These data demonstrate the effectiveness of pancreatic grafting in normalizing glucose metabolism, although hyperinsulinaemia and deranged counterregulatory hormone response are observed frequently.

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“…Plasma CCK concentrations (pmol/l) were determined by a sensitive and specific radioimmunoassay (45). In short, the antibody (CH40IX) raised in rabbits, was specifically directed to the biologically active site of CCK, including the sulfated tyrosyl residue at position 7 from the COOH-terminal end, and showed no crossreactivity with unsulfated CCK-8, unsulfated gastrin-17, or unsulfated gastrin-34.…”

Section: Measurementsmentioning

confidence: 99%

Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men

Brennan

Luscombe-Marsh

Seimon

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

155

111

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Brennan IM, Luscombe-Marsh ND, Seimon RV, Otto B, Horowitz M, Wishart JM, Feinle-Bisset C. Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men. Am J Physiol Gastrointest Liver Physiol 303: G129 -G140, 2012. First published April 30, 2012 doi:10.1152/ajpgi.00478.2011.-While protein is regarded as the most satiating macronutrient, many studies have employed test meals that had very high and unsustainable protein contents. Furthermore, the comparative responses between lean and obese subjects and the relationships between energy intake suppression and gut hormone release remain unclear. We evaluated the acute effects of meals with modest variations in 1) fat, protein, and carbohydrate content and 2) protein load on gastrointestinal hormones, appetite, and subsequent energy intake in lean and obese subjects. Sixteen lean and sixteen obese men were studied on four occasions. Following a standardized breakfast, they received for lunch: 1) high-fat (HF), 2) high-protein (HP), 3) high-carbohydrate/low-protein (HC/LP), or 4) adequateprotein (AP) isocaloric test meals. Hunger, fullness, and gut hormones were measured throughout, and at t ϭ 180 min energy intake at a buffet meal was quantified. In lean subjects, hunger was less and fullness greater following HF, HP, and AP compared with HC/LP meals, and energy intake was less following HF and HP compared with HC meals (P Ͻ 0.05). In the obese subjects, hunger was less following HP compared with HF, HC/LP, and AP meals, and energy intake was less following HP and AP compared with HF and HC meals (P Ͻ 0.05). There were no major differences in hormone responses to the meals among subject groups, but the CCK and ghrelin responses to HP and AP were sustained in both groups. In conclusion, HP meals suppress energy intake in lean and obese subjects, an effect potentially mediated by CCK and ghrelin, while obese individuals appear to be less sensitive to the satiating effects of fat. diet composition; obesity; protein intake; dietary macronutrients; gut hormone release THE CURRENT AVERAGE WESTERN diet derives ϳ50% of energy from carbohydrate, 35% from fat, and 15% from protein (35), which represents a shift toward an increased carbohydrate and reduced protein intake when compared with the diet of our hunter-gatherer ancestors (14). Of the dietary macronutrients, protein is generally regarded as the most satiating nutrient. Accordingly, one dietary strategy for the management of obesity has been to replace some carbohydrate in the diet with protein (2,19,49), although the benefit of this approach remains uncertain (24,29,48). A recent study indicated that in obese subjects weight regain after a 26-wk period was less (by 930 g) in response to a high-protein diet (25% energy from protein), compared with a low-protein diet (13% energy from protein) (29). There is little definitive information about the comparative effects of the three macronutrients or differences in protein l...

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Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man

Cited by 33 publications

References 34 publications

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Review:The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

Metabolic and hormonal studies of Type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation

Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men

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