Hemodialysis patients with chronic kidney disease commonly exhibit physical deconditioning in line with protein-energy wasting and frailty [1]. Enhancing physical activity improves body composition and preserves muscle mass in hemodialysis patients [2]. Intradialytic exercise modulates the metabolic balance by stimulating anabolic activity in muscle tissues with anabolic nutritional support in patients undergoing dialysis [3]. In contrast to previous literature, this study did not detect any beneficial effects on body composition parameters, including skeletal muscle mass, lower leg muscle mass, and body fat mass, after 40 to 70 minutes of ergometer cycling during each hemodialysis session, three times a week for 12 weeks, despite improvements in frailty, dialysis adequacy, and quality of life (QoL) [4]. These results suggest that the authors did not consider the effect of nutritional factors on body composition profiles [1,4].Nutritional support or exercise training is associated with