Effect of intracoronary and intravenous propranolol on human coronary arteries

Abstract

KEY WORDS: Coronary vasomotion, quantitative coronary arteriography, bicycle exercise, intracoronary and intravenous propranolol, coronary artery disease, nitroglycerin. In NS vs rest; NS vs rest) The effect of intracoronary and intravenous propranolol on coronary vasomotion was evaluated in the control group there was coronary vasodilation (+23%, P <001) of the normal and coronary vasoconstriction (-29%, P < 0-001) of the stenotic vessel segment during bicycle exercise. After sublingual administration of 1-6 mg nitroglycerin there was vasodilation of-both normal (+40%, P <0-001 vs rest) and stenotic (+12%, NS vs rest) vessel segments. In group 2 intracoronary propranolol was not accompanied by a change in coronary vessel area but both normal (+13%, P<0-05) and stenotic (+22%, P<0-05) vessel segments showed coronary vasodilation during bicycle exercise. After sublingual nitroglycerin there was further vasodilation of both normal (+31 %, P < 0-001 vs rest) and stenotic (+45%, P < 0-01 vs rest) arteries. In group 3 intravenous administration of propranolol was associated with a decrease in coronary luminal area of both normal (-24%, P <0-001) and stenotic (-31%, P <0-001) vessel segments. During dynamic exercise there was coronary vasodilation of both vessel segments when compared with the data after intravenous injection of propranolol but there was no change in luminal area Introductionand exercise-induced myocardial ischaemia. The _, .. .

Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study

“…In contrast, the non-selective beta-blocker propranolol causes attenuation of endothelial function during direct intra-arterial infusion and causes coronary artery vasoconstriction [25,27,28]. Four months treatment with carvedilol in patients with coronary artery disease improved endothelial function whereas no change was seen after short term treatment of 2 hours [29].…”

Randomised comparison of the effects of nicardipine and esmolol on coronary artery wall stress: implications for the risk of plaque rupture

“…By comparison, β blockers—which do not cause coronary vasodilatation—may be more effective at reducing coronary artery wall stress. In this study homogeneous arterial segments were studied, but both β blockers26 and dihydropyridine calcium antagonists17 are known to have similar vasomotor effects in normal and diseased segments of artery.…”