Effect of intracisternal administration of prostaglandin E1 on waking and sleep in the rat

Mašek, K.; Kadlecová, O.; Pöschlová, N

doi:10.1016/0028-3908(76)90060-5

Cited by 15 publications

(2 citation statements)

References 10 publications

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“…Additionally, sleep is inhibited with the COX-1 and COX-2 inhibitor acetaminophen. Moreover, two downstream prostanoids, prostaglandin D 2 and prostaglandin E 2 are posited to be involved in sleep and wake regulation (52, 53), respectively.…”

Section: Inflammatory Cellular Pathwaysmentioning

confidence: 99%

Sleep and innate immunity

Zielinski

Krueger²

2011

Front Biosci

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Many pro-inflammatory molecules, such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) are somnogenic, while many anti-inflammatory molecules inhibit sleep. Sleep loss increases the production/release of these sleep regulatory pro-inflammatory molecules. Further, sleep changes occurring during various pathologies are mediated by these inflammatory substances in response to pathogen recognition and subsequent inflammatory cellular pathways. This review summarizes information and concepts regarding inflammatory mechanisms of the innate immune system that mediate sleep. Further, we discuss sleep-immune interactions in regards to sleep in general, pathologies, and sleep as a local phenomenon including the central role that extracellular ATP plays in the initiation of sleep.

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Section: Inflammatory Cellular Pathwaysmentioning

confidence: 99%

Sleep and innate immunity

Zielinski

Krueger²

2011

Front Biosci

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“…Inhibiting COX-2 activity attenuates spontaneous NREM sleep and sleep induced by TNF-α [7,36]. Additionally, sleep is inhibited by the COX-1 and COX-2 inhibitor acetaminophen and PGD2 and prostaglandin E2, which are downstream products of COX activity and are implicated in the regulation of sleep and wakefulness [37,38].…”

Section: ) Prostaglandinmentioning

confidence: 99%

The relationship between sleep and innate immunity

Lee,

Park

2024

encephalitis

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Numerous studies have focused on the relationship between sleep and immunity. Conditions such as chronic insomnia or obstructive sleep apnea, which result in sleep deprivation, are reciprocally associated with innate immunity [1,2]. Sleep regulatory substances, which control sleeping patterns, exhibit oscillations in the brain according to sleep/wake cycles. Interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), growth hormone-releasing hormone, prolactin, and nitric oxide (NO) are known proinflammatory, somnogenic (sleep regulatory) substances [1,2]. When injected into the central nervous system (CNS), sleep regulatory substances systemically induce either an increase or decrease in sleep. Inhibiting or removing sleep regulatory substances leads to changes in sleep patterns, and such substances are altered in response to pathogens [1,3].Both sleep and innate immunity are influenced by circadian rhythms (Figure 1). In humans, leukocyte trafficking increases with peak circulating immune cell numbers at night. Leukocyte oscillation does not occur without stimuli like the light-

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Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise

Zielinski

Gerashchenko

2015

Diet and Exercise in Cognitive Function and Neurological Diseases

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Effect of intracisternal administration of prostaglandin E1 on waking and sleep in the rat

Cited by 15 publications

References 10 publications

Sleep and innate immunity

Sleep and innate immunity

The relationship between sleep and innate immunity

Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise

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