Effect of intracameral epinephrine use on macular thickness after uneventful phacoemulsification

Abstract

No author has a financial or proprietary interest in any material or method mentioned.

Corticosteroids and Anti-Complement Therapy in Retinal Diseases

“…Although it is normally obtained with topical instillation of eyedrops before the surgery, a combination of topical and intracameral agents has also been used for mydriasis (Duffin et al 1983 The safety of ICM has been studied in animals (Liou et al 2002;Kim et al 2010) and humans (Bozkurt et al 2010;Cakmak et al 2010). Special attention has been paid to circulatory consequences during the use intracameral epinephrine.…”

Mydriatic insert and intracameral injections compared with mydriatic eyedrops in cataract surgery: Controlled studies

“…58,59,65 The effect of mydriatic eyedrops tends to wear off during cataract surgery 48 in conjunction with an intraoperative reflex miosis 66,67 caused by the release of prostaglandins 21 or operative factors (eg, light from the microscope). 68 This increases the risk for surgeryrelated complications 1,67 and is more frequent in certain patients (eg, diabetics). 69 Repeated instillations are time consuming, substantially affect nurses' workload, and may lead to imprecise dosing; protocols have to be adapted to patients' characteristics, such as iris pigmentation.…”

“…Eight studies (7 RCTs, 1 case-control study; 646 patients) compared the efficacy and safety of intracameral mydriatic injections with those of control mydriatics 5,45,48,68,79,83,86,87 ; 7 RCTs (374 patients) defined the optimum intracameral mydriatic injection protocol. 3,8,40,67,77,78,88 All trials used preservative-free formulations of intracameral mydriatic injections.…”

“…Four of the RCTs had a blinded design 5,48,86,87 and 3 an open-label design. 68,79,83 A triple solution of cyclopentolate, lidocaine, and phenylephrine was used in 4 studies, 45,48,86,87 a double solution of lidocaine and phenylephrine solution in 2 studies, 5,79 and single agents in 2 studies (lidocaine 83 or epinephrine, 68 1 study each). Dilation in control arms was based on mydriatic eyedrops, usually the combination of cyclopentolate 0.85% to 1.0% and phenylephrine 5.0% to 10.0% 45,48,79,83,87 or tropicamide 0.5% to 1.0% and phenylephrine 2.5% to 10.0%.…”

“…Dilation in control arms was based on mydriatic eyedrops, usually the combination of cyclopentolate 0.85% to 1.0% and phenylephrine 5.0% to 10.0% 45,48,79,83,87 or tropicamide 0.5% to 1.0% and phenylephrine 2.5% to 10.0%. 5,68 Intracameral injections of lidocaine 1.0% were associated with mydriatic eyedrops in 5 studies 45,48,79,86,87 ; epinephrine 0.6 mg/mL in irrigating balanced salt solution was used in both the experimental and control arms in 3 studies 48,86,87 ; 1 RCT compared the effects of intracameral mydriatic injections and those of mydriatic eyedrops and the mydriatic ophthalmic insert across 3 parallel groups. 5 Pupil diameter was most often evaluated on digital video recordings.…”