Effect of intra‐operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery

Levaux, Christine; Bonhomme, Vincent; Dewandre, Pierre-Yves; Brichant, Jean-François; Hans, Pol

doi:10.1046/j.1365-2044.2003.02999.x

Cited by 140 publications

(111 citation statements)

References 14 publications

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“…The results showed that in the group receiving magnesium, postoperative pain scores, and consumption of analgesics during surgery were lower than those of the patients in the control group were. In addition, recovery of neuromuscular block was longer than magnesium sulfate group (17). The mechanism of analgesic effect of magnesium is not entirely clear; however, it seems interfering with calcium channels and NMDA receptors play an important role in this regard.…”

Section: Discussionmentioning

confidence: 87%

The Effect of Magnesium Sulfate on Postoperative Pain Severity and Complications in Patients Undergoing Coronary Artery Bypass Grafting

Manafi¹,

Davoudi²,

Safarpoor³

et al. 2017

Res Cardiovasc Med

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Section: Discussionmentioning

confidence: 87%

The Effect of Magnesium Sulfate on Postoperative Pain Severity and Complications in Patients Undergoing Coronary Artery Bypass Grafting

Manafi¹,

Davoudi²,

Safarpoor³

et al. 2017

Res Cardiovasc Med

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“…Many studies evaluating. 5 the effect of magnesium sulphate in postoperative analgesia have not measured the postoperative sedation scores. These results are different from the studies where patients receiving magnesium sulphate were not observed to be sedated in spite of using magnesium sulphate as bolus and/or infusion.…”

Section: Discussionmentioning

confidence: 99%

Effect of Preoperative Magnesium Infusion on Postoperative Pain in Patients Under General Anaesthesia

Nidhin¹,

Abraham²

2016

jemds

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Despite the availability of newer clinical practice objectives, effective analgesics and new technologies for pain measurement, the management of postoperative pain continues to remain a problem. Patients have the right to be recognized as experts of their own pain experience and to have their pain report reflected accurately in the type of pain relief they receive. They also have the right to expect that relief of their pain be considered to be a reasonable goal of the treatment. With the increasing understanding of pain physiology and the (N-Methyl D Aspartate) NMDA receptor, the use of Magnesium for secondary analgesia and as an adjuvant to different regimens is introducing newer possibilities for the use of Magnesium in acute and chronic pain. The popularity of Magnesium sulphate in wide spectrum of clinical application also finds its use in attenuating postoperative pain. In our study, we will be assessing the patients while they are undergoing surgery and their postoperative pain scores when the patient is premedicated with Magnesium sulphate. MATERIALS AND METHODS60 patients undergoing general surgery were randomly divided into 2 groups of 30 each. The Magnesium sulphate group received 50mg/kg in 100mL of normal saline solution over 30 minutes before the surgery intravenously, whereas control group received same volume of normal saline solution over 30 minutes preoperatively. RESULTSData collected was subjected to standard statistical analysis and analysed using Chi-square test. There was significant difference in the pain scores after the injection of Magnesium sulphate between both the groups. CONCLUSIONWe found out that majority of patients find relief, while a minority of patients had the issue of nausea and vomiting. We conclude that Magnesium sulphate provides a good pain relief without any significant adverse effects.

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“…(13) 4 'ın postoperatif morfin tüketimi üzerine etkilerini karşılaştırdıkları çalışmalarında, çalışma ajanları ile morfin tüketiminde bir azalma elde edemediklerini bildirilmişlerdir. Buna karşın magnezyum uygulamasının intraoperatif anestetik ve analjezik ihtiyacını, postoperatif ağrıyı ve analjezi tüketimini azalttığını bildiren çok sayıda çalışma da mevcuttur (14,15). Apan ve ark.…”

Section: Discussionunclassified

The Effect of Intravenous Magnesium Sulphate Treatment on the Spinal Anaesthesia Produced by Bupivacaine in Pre-eclamptic Patients

Atci¹,

Ünlügenç²,

Güneş³

et al. 2015

Turk J Anesth Reanim

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Objective: In our study, the effect of intravenous magnesium sulphate in normal and pre-eclamptic patients on spinal anaesthesia produced by bupivacaine was investigated.Methods: Sixty-four pregnant (32 normal and 32 pre-eclamptic) were accepted in this study. Pregnants were divided into four groups as patients given intravenous magnesium sulphate and as control. Spinal anaesthesia was induced with 12.5 mg 0.5% hyperbaric bupivacaine. Intraoperative and postoperative haemodynamic variables, sensorial block periods, onset times of sensorial and motor block, maximum sensorial block levels, the time to reach maximum block level, Bromage scores, consumptions of intraoperative analgesic and ephedrine, the quality of anaesthesia, the duration of spinal anaesthesia and magnesium levels in blood and cerebrospinal fluid were measured and recorded. Results:The level of magnesium in blood and cerebrospinal fluid was significantly higher in the group given magnesium in pre-eclamptic patients (p<0.01). Onset of sensory block times were significantly longer in intravenous magnesium group than in groups 1, 2 and 3 (p<0.05). Onset of motor block times were significantly longer and the duration of anaesthesia was shorter in groups given magnesium (p<0.05). Although the quality of anaesthesia was similar, supplemental analgesic consumption was significantly higher in pre-eclamptic pregnants given magnesium sulphate than in pre-eclamptic pregnants who were not given magnesium sulphate (p<0.05). Conclusion:Intravenous magnesium sulphate treatment during the spinal anaesthesia produced by bupivacaine extended the onset of sensory and motor block times, shortened the duration of spinal anaesthesia and therefore led to early analgesic requirement.Key Words: Spinal anaesthesia, magnesium sulphate, bupivacaine, pre-eclampsia Amaç: Çalışmamızda normal ve preeklamptik gebelerde intravenöz magnezyum sülfat tedavisinin bupivakain ile oluşturulan spinal anesteziye etkileri araştırıldı.Yöntemler: Çalışmamıza 32 normal sağlıklı, 32 preeklamptik toplam 64 gebe alındı. Olgular; intravenöz magnezyum sülfat tedavisi alan ve almayan olmak üzere toplam 4 gruba ayrıldı. Tüm gruplara 12,5 mg %0,5 hiperbarik bupivakain ile spinal anestezi uygulandı. İntraoperatif ve postoperatif hemodinamik değişkenler, sensoryal blok süreleri, sensoryal ve motor blok başlama süreleri, maksimum sensoryal blok seviyesi ve maksimum blok seviyesine ulaşma süreleri, bromage skorunun gerileme süreleri, intraoperatif analjezik ve efedrin gereksinimleri, anestezi kalitesi ve spinal anestezi süreleri ile kan ve beyin-omurilik sıvısı (BOS) magnezyum düzeyleri ölçülerek kaydedildi. Bulgular:Kan ve BOS magnezyum düzeyleri, magnezyum tedavisi alan preeklamptik gebelerde almayan gruplara göre önemli derecede yüksek bulundu (p<0,01). Sensoryal blok başlama zamanı grup intravenözde (IV) grup 1, 2 ve 3'e göre istatistiksel olarak önemli derecede uzun bulundu (p<0,05). Motor blok başlangıç sürelerinin magnezyum tedavisi uygulanan gruplarda önemli derecede uzun, anestezi sürelerinin ise...

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Effect of intra‐operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery

Cited by 140 publications

References 14 publications

The Effect of Magnesium Sulfate on Postoperative Pain Severity and Complications in Patients Undergoing Coronary Artery Bypass Grafting

The Effect of Magnesium Sulfate on Postoperative Pain Severity and Complications in Patients Undergoing Coronary Artery Bypass Grafting

Effect of Preoperative Magnesium Infusion on Postoperative Pain in Patients Under General Anaesthesia

The Effect of Intravenous Magnesium Sulphate Treatment on the Spinal Anaesthesia Produced by Bupivacaine in Pre-eclamptic Patients

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