Effect of Intra- and Extrauterine Growth on Long-Term Neurologic Outcomes of Very Preterm Infants

Guellec, Isabelle; Lapillonne, Alexandre; Marret, Stéphane; Mitanchez, Delphine; Charkaluk, Marie‐Laure; Arnaud, Catherine; Flamand, Cyril; Cambonie, Gilles; Ancel, Pierre‐Yves; Larroque, Béatrice; Ancel, Pierre–Yves; Blondel, Béatrice; Bréart, G; Garel, M.; Kaminski, Monique; Maillard, Florie; Mazaubrun, Christiane Du; P., Missy,; F., Sehili,; Supernant, Karine; Marchand, Laëtitia; Durand, Manuel; Matis, Jacqueline; Messer, J; Treisser, A; Burguet, A.; Abraham‐Lerat, Laurence; Menget, A.; Roth, P.; Schaal, J.-P.; Thiriez, Gérard; Lévêque, C.; Marret, Stéphane; Marpeau, L.; Boulot, P.; Cambonie, Gilles; Picaud, Jean‐Charles; Donadio, A.M.; Ledésert, Bernard; André, M; Fresson, Jeanne; Hascoët, Jean Michel; Arnaud, Catherine; Grandjean, Hélène; Rolland, Matthieu; Fily, A.; Ego, Anne; Outtier, M.L.; Pierrat, Véronique; Subtil, D.; Truffert, Patrick; Boog, G.; Rouger-Bureau, V.; Rozé, Jean‐Christophe; Dehan, M; Zupan-Simunek, V.; Vodovar, M; Voyer, M

doi:10.1016/j.jpeds.2016.05.027

Cited by 126 publications

(98 citation statements)

References 35 publications

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“…Regardless of catch-up growth, small-for-gestational age (SGA) children seem to have an increased risk of neurocognitive deficits [4]. Therefore, SGA infants may need to continue catch-up growth for a longer period of time than non-SGA infants.…”

Section: Introductionmentioning

confidence: 99%

Catch-Up Growth, Rapid Weight Growth, and Continuous Growth from Birth to 6 Years of Age in Very-Preterm-Born Children

Toftlund¹,

Halken²,

Agertoft³

et al. 2018

Neonatology

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Background: Breastfeeding promotes healthy growth in very-preterm-born infants (VPI), but extra nutritional supply is needed to ensure catch-up growth and brain development. Objectives: To investigate how different types of post-discharge nutrition affect growth until 6 years of age in children born VPI. Methods: This was a 6-year follow-up study of 281 VPI. Median gestational age (GA) was 30 + 0 weeks (range 24–32 weeks). When breastfed at discharge, they were randomized to unfortified human milk (UHM) or fortified human milk (FHM). If not breastfed at discharge, they received a preterm formula (PF). The intervention lasted until 4 months of corrected age (CA). At 6 years CA, their height and weight were measured. Results: A total of 239 children participated in the follow-up. UHM-feeding compared to both PF- and FHM-feeding resulted in a slower but continuous catch-up growth until 6 years of age. Participants born small-for-GA compared to appropriate-for-GA more often demonstrated continuous catch-up growth until 6 years of age (p = 0.018). Rapid weight growth (a change in z score > 1 SD during a short time period) was found to be most pronounced from 34 weeks post-menstrual age to 2 months CA, and especially among those fed PF (p = 0.002 vs. UHM, p = 0.07 vs. FHM). Conclusions: Catch-up growth occurred mainly before discharge, regardless of the feeding group. UHM-fed infants demonstrated catch-up growth that was slower, but extended until 6 years of age. Rapid weight growth was most pronounced shortly after discharge and especially if PF-fed.

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Section: Introductionmentioning

confidence: 99%

Catch-Up Growth, Rapid Weight Growth, and Continuous Growth from Birth to 6 Years of Age in Very-Preterm-Born Children

Toftlund¹,

Halken²,

Agertoft³

et al. 2018

Neonatology

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“…We interpret these data to suggest that intrauterine growth failure may affect early infant growth patterns. It is notable that, with intrauterine growth restriction, later overnutrition and consequent rapid growth are associated with metabolic consequences [26], and undernutrition [7] and deficient growth [27] with developmental consequences. This dilemma calls for more research to understand the determinants of healthy development in this population that faces greater health risks.…”

Section: Discussionmentioning

confidence: 99%

Early Nutrition and Growth until the Corrected Age of 2 Years in Extremely Preterm Infants

et al. 2017

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Background: Extremely preterm birth is associated with a high risk of extrauterine growth retardation, which has been linked with adverse developmental outcomes. Objective: We investigated whether nutritional management during the first 7 days of life affects growth patterns until the corrected age of 2 years in extremely preterm infants. Study Design: A retrospective study of 78 extremely preterm (<28 weeks' gestation) neonates was conducted. Data regarding parenteral and enteral intake of energy, protein, lipids, and carbohydrates during the first 7 days of life were collected from patient records. The outcome measures included weight, height, and head circumference with Z scores at term-equivalent age and the corrected ages of 1 and 2 years. Analyses were performed with hierarchical-linear mixed models. Results: Nutritional intake during the first week of life did not reach the current recommendations. The total energy intake during the first 7 days of life was statistically significantly associated with weight, length, and head circumference until the corrected age of 2 years after adjusting for potential confounding factors. Individual macronutrient intake displayed no association with growth patterns. Conclusions: Energy intake during the first 7 days of life is associated with growth until the corrected age of 2 years. These results provide support for the aggressive early nutritional management of extremely preterm infants.

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“…Small babies and preterm babies have highly increased risks of neurological deficits and postnatal complications, especially sepsis [28][29][30][31][32]. The risks may be higher in lowincome countries, since survival and deficit-free survival depend on the provision of postnatal intensive care [20,21].…”

Section: What We Knowmentioning

confidence: 99%

What we do and do not know about women and kidney diseases; questions unanswered and answers unquestioned: reflection on World Kidney Day and International Women’s Day

et al. 2018

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Chronic Kidney Disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Gender differences continue to exist around the world in access to education, medical care, and participation in clinical studies. Pregnancy is a unique state for women, offering an opportunity for diagnosis of kidney disease, but also a state where acute and chronic kidney diseases may manifest, and which may impact future generations with respect to kidney health. There are various autoimmune and other conditions that are more likely to impact women with profound consequences for child bearing, and on the fetus. Women have different complications on dialysis than men, and are more likely to be donors than recipients of kidney transplants. In this editorial, we focus on what we do and do not know about women, kidney health, and kidney disease, and what we might learn in the future to improve outcomes worldwide.

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Effect of Intra- and Extrauterine Growth on Long-Term Neurologic Outcomes of Very Preterm Infants

Cited by 126 publications

References 35 publications

Catch-Up Growth, Rapid Weight Growth, and Continuous Growth from Birth to 6 Years of Age in Very-Preterm-Born Children

Catch-Up Growth, Rapid Weight Growth, and Continuous Growth from Birth to 6 Years of Age in Very-Preterm-Born Children

Early Nutrition and Growth until the Corrected Age of 2 Years in Extremely Preterm Infants

What we do and do not know about women and kidney diseases; questions unanswered and answers unquestioned: reflection on World Kidney Day and International Women’s Day

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