Effect of Intra-amniotic Oestriol Sulphate on Uterine Contractions

Klopper, Arnold; Dennis, K. J.; Farr, Valerie

doi:10.1136/bmj.2.5660.786

Cited by 14 publications

(4 citation statements)

References 6 publications

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“…It is not evaluating a policy of stopping the pregnancy at 41 weeks Ingemarsson 1987 Trial of cervical ripening not IOL. Iqbal 2004 Alternate allocation trial. Jenssen 1977 Trial of cervical ripening not IOL. Kadar 1990 Trial of nipple stimulation as a method of cervical ripening. No commitment to delivery within a given time or protocol Katz 1983 Alternate allocation trial. Kipikasa 2005 Comparing alternate methods for induction of labour. Klopper 1969 Trial of cervical ripening not IOL. Knox 1979 Quasi-randomised (last digit of hospital number). Lee 1997 2 forms of IOL. Lemancewicz 1999 2 forms of IOL. Lien 1998 Trial of cervical ripening not IOL. Lyons 2001 Trial of cervical ripening not IOL. Magann 1998 Trial of cervical ripening not IOL. Magann 1999 2 forms of IOL. Mancuso 1998 2 forms of IOL. Martin 1978 About 30% of randomly allocated women in both groups were excluded from analysis due to protocol violations Meydanli 2003 2 forms of IOL. Misra 1994 2 forms of IOL. …”

Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

Induction of labour for improving birth outcomes for women at or beyond term

Gülmezoglu

Crowther

Middleton

et al. 2012

Cochrane Database of Systematic Reviews

159

104

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Background As a pregnancy continues beyond term the risks of babies dying inside the womb or in the immediate newborn period increase. Whether a policy of labour induction at a predetermined gestational age can reduce this increased risk is the subject of this review. Objectives To evaluate the benefits and harms of a policy of labour induction at term or post-term compared with awaiting spontaneous labour or later induction of labour. Search methods We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (31 March 2012). Selection criteria Randomised controlled trials conducted in women at or beyond term. The eligible trials were those comparing a policy of labour induction with a policy of awaiting spontaneous onset of labour. Cluster-randomised trials and cross-over trials are not included. Quasi-random allocation schemes such as alternation, case record numbers or open random-number lists were not eligible. Data collection and analysis Two review authors independently assessed trials for inclusion. Two review authors independently assessed trial quality and extracted data. Data were checked for accuracy. Outcomes are analysed in two main categories: gestational age and cervix status. Main results We included 22 trials reporting on 9383 women. The trials were generally at moderate risk of bias. Compared with a policy of expectant management, a policy of labour induction was associated with fewer (all-cause) perinatal deaths: risk ratio (RR) 0.31, 95% confidence interval (CI) 0.12 to 0.88; 17 trials, 7407 women. There was one perinatal death in the labour induction policy group compared with 13 perinatal deaths in the expectant management group. The number needed to treat to benefit (NNTB) with induction of labour in order to prevent one perinatal death was 410 (95% CI 322 to 1492). For the primary outcome of perinatal death and most other outcomes, no differences between timing of induction subgroups were seen; the majority of trials adopted a policy of induction at 41 completed weeks (287 days) or more. Fewer babies in the labour induction group had meconium aspiration syndrome (RR 0.50, 95% CI 0.34 to 0.73; eight trials, 2371 infants) compared with a policy of expectant management. There was no statistically significant difference between the rates of neonatal intensive care unit (NICU) admission for induction compared with expectant management (RR 0.90, 95% CI 0.78 to 1.04; 10 trials, 6161 infants). For women in the policy of induction arms of trials, there were significantly fewer caesarean sections compared with expectant management in 21 trials of 8749 women (RR 0.89, 95% CI 0.81 to 0.97). Authors’ conclusions A policy of labour induction compared with expectant management is associated with fewer perinatal deaths and fewer caesarean sections. Some infant morbidities such as meconium aspiration syndrome were also reduced with a policy of post-term labour induction although no significant differences in the rate of NICU admission were seen. However, the absolute risk of peri...

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Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

Induction of labour for improving birth outcomes for women at or beyond term

Gülmezoglu

Crowther

Middleton

et al. 2012

Cochrane Database of Systematic Reviews

159

104

View full text Add to dashboard Cite

show abstract

“…Kipikasa 2005 Comparing alternate methods for induction of labour. Klopper 1969 Trial of cervical ripening not IOL. Knox 1979 Quasi-randomised (last digit of hospital number).…”

Section: Iqbal 2004mentioning

confidence: 99%

Induction of labour for improving birth outcomes for women at or beyond term

Gülmezoglu¹,

Crowther²

2004

Cochrane Database of Systematic Reviews

109

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Background-As a pregnancy continues beyond term the risks of babies dying inside the womb or in the immediate newborn period increase. Whether a policy of labour induction at a predetermined gestational age can reduce this increased risk is the subject of this review. Objectives-To evaluate the benefits and harms of a policy of labour induction at term or postterm compared with awaiting spontaneous labour or later induction of labour. Search methods-We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2012). Selection criteria-Randomised controlled trials conducted in women at or beyond term. The eligible trials were those comparing a policy of labour induction with a policy of awaiting spontaneous onset of labour. Cluster-randomised trials and cross-over trials are not included. Quasi-random allocation schemes such as alternation, case record numbers or open randomnumber lists were not eligible. Data collection and analysis-Two review authors independently assessed trials for inclusion. Two review authors independently assessed trial quality and extracted data. Data were

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“…clinical features of the patients in the two groups. Initial assessment of the cervix was made using a modified Bishop score (Klopper et al, 1969):…”

Section: Methodsmentioning

confidence: 99%

UTERINE ACTIVITY IN lNDUCED LABOUR

Steer¹,

Little²,

Lewis³

et al. 1975

BJOG

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Summary A study was made of the characteristics of oxytocin‐induced labour. Twelve patients with, and eight without membrane rupture were closely matched for factors likely to influence the character and duration of labour. In both groups uterine activity increased until a stable state was achieved following which there was little alteration until delivery. The duration of labour was shorter in the group with ruptured membranes as compared with intact membranes although, paradoxically, the uterine activity tended to be greater when the membranes were intact.

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Effect of Intra-amniotic Oestriol Sulphate on Uterine Contractions

Cited by 14 publications

References 6 publications

Induction of labour for improving birth outcomes for women at or beyond term

Induction of labour for improving birth outcomes for women at or beyond term

Induction of labour for improving birth outcomes for women at or beyond term

UTERINE ACTIVITY IN lNDUCED LABOUR

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