Effect of intra‐abdominal administration of ligustrazine nanoparticles nano spray on postoperative peritoneal adhesion in rat model

Yan, Shuai; Yue, Yinzi; Zeng, Li; Jin, Yue; Li, Wenlin; Mao, Chunqin; Yang, Lan-Yan

doi:10.1111/jog.12807

Cited by 16 publications

(15 citation statements)

References 31 publications

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“…Adhesions can develop when inflammatory responses perturb the equilibrium between fibrin formation and fibrinolysis [ 5 ]. The most common symptoms are chronic abdominal pain, small bowel obstruction, and secondary female infertility [ 3 , 4 , 6 , 7 ]. These complications cause significant morbidity and pose a significant economic burden [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

A pectin-honey hydrogel prevents postoperative intraperitoneal adhesions in a rat model

et al. 2016

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BackgroundAdhesions are a common postoperative surgical complication. Liquid honey has been used intraperitoneally to reduce the incidence of these adhesions. However, solid barriers are considered more effective than liquids in decreasing postoperative intra-abdominal adhesion formation; therefore, a new pectin-honey hydrogel (PHH) was produced and its effectiveness was evaluated in a rat cecal abrasion model.Standardized cecal/peritoneal abrasion was performed through laparotomy in 48 adult Sprague-Dawley rats to induce peritoneal adhesion formation. Rats were randomly assigned to a control (C) and treatment (T) group. In group T, PHHs were placed between the injured peritoneum and cecum. Animals were euthanized on day 15 after surgery. Adhesions were evaluated macroscopically and adhesion scores were recorded and compared between the two groups. Inflammation, fibrosis, and neovascularization were histologically graded and compared between the groups.ResultsIn group C, 17 of 24 (70.8%) animals developed adhesions between the cecum and peritoneum, while in group T only 5 of 24 (20.8%) did (p = 0.0012). In group C, one rat had an adhesion score of 3, sixteen had scores of 2, and seven rats had scores of 0. In group T, four rats had adhesion scores of 2, one rat had an adhesion score of 1 and nineteen have score 0 (p = 0.0003). Significantly lower grades of inflammation, fibrosis, and neovascularization were seen in group T (p = 0.006, p = 0.001, p = 0.002, respectively).ConclusionPHH is a novel absorbable barrier that is effective in preventing intra-abdominal adhesions in a cecal abrasion model in rats.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-017-0965-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

A pectin-honey hydrogel prevents postoperative intraperitoneal adhesions in a rat model

et al. 2016

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“…In the literature, postoperative peritoneal adhesions are among the most common causes of ileus. Today, studies using advanced nanotechnology products and different agents to prevent intraabdominal adhesions are ongoing at a fast pace and a further step is taken each day to obtain a curative solution [11]. To prevent intra-abdominal adhesions and keep them at the minimum level, many approaches, such as usage of anti-inflammatory agents, antibiotics, fibrinolytic agents, chemical and physical barriers, have been tried [12].…”

Section: Discussionmentioning

confidence: 99%

Effects of heparin and prednisolone on postoperative intra-abdominal adhesions in Wistar rats

Çakır¹,

Okuyan²,

Tokgöz³

et al. 2020

Journal of Surgery and Medicine

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Aim: Postoperative intra-abdominal adhesions are one of the complications surgeons want to avoid. It was aimed to compare the effects of physiological saline, heparin, Ringer's lactate, and prednisolone, which have been commonly used for surgical adhesions, with repeated lavage on postoperative adhesions. Methods: Upon the approval of the Ethics Committee of Fırat University, Faculty of Medicine, 35 Wistar Albino (female) rats were randomized into 5 groups (Heparin BID, Heparin QD, Prednisolone QD, Prednisolone BID, and Control) of 7 rats, and adhesion was created with peritoneal injury model in all rats. The differences in the adhesions created between groups were compared using the macroscopic adhesion scoring system of Linsky. Results: No significant differences were found between physiological saline-heparin and Ringer's lactate-prednisolone groups in terms of adhesion scores (P=0.06). There was a difference in adhesion severity on the left only in the groups receiving heparin QD and prednisolone QD (P=0.04). Conclusion: We demonstrated that none of the agents (Physiological saline, Heparin, Ringer's lactate, and prednisolone) we used in our study model reduced adhesions. It is thought that no difference was detected because of the adhesion model we established. Advanced technology-based studies are still needed to prevent postoperative intra-abdominal adhesions that are globally observed to reduce a huge economic burden and decrease mortality and morbidity.

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“…Data from the first in-human randomized control trial suggests the product is safe and effective in reducing post-operative adhesion development, particularly following myomectomy [383]. Although the spray delivery systems facilitate easier use and can incorporate various products, none have been consistently effective in preventing post-operative adhesion formation [384][385][386][387].…”

Section: Spray Type Barriersmentioning

confidence: 99%

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

et al. 2021

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Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

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Effect of intra‐abdominal administration of ligustrazine nanoparticles nano spray on postoperative peritoneal adhesion in rat model

Abstract: We suggest that LNNS could reduce peritoneal adhesion formation and it could be applied as a novel intervention for postoperative peritoneal adhesion.

Cited by 16 publications

References 31 publications

A pectin-honey hydrogel prevents postoperative intraperitoneal adhesions in a rat model

A pectin-honey hydrogel prevents postoperative intraperitoneal adhesions in a rat model

Effects of heparin and prednisolone on postoperative intra-abdominal adhesions in Wistar rats

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies

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