Effect of Intestinal Microflora on Iron and Zinc Metabolism, and on Activities of Metalloenzymes in Rats

Reddy, Bandaru S.; Pleasants, Julian R.; Wostmann, Bernard S.

doi:10.1093/jn/102.1.101

Cited by 46 publications

(40 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our present report appears to agree with this observation, since iron intake in our experiments was 1.3mg for deficient groups and 2.4mg for the control groups in both conventional and germ-free rats. REDDY et al and WOSTMAN et al reported that germ-free rats with an absence of viable intestinal microflora had markedly decreased absorption and net retention of iron (8,20), but a decrease in iron levels in germ-free rats was not observed in this study.…”

Section: Resultscontrasting

confidence: 69%

“…DISCUSSION REDDY et al reported that there was no significant difference between germ-free and conventional rats in the absorption and net retention of zinc (8). On the other hand, it has been shown that bacterial endotoxin results in a rapid decrease in plasma zinc concentration in both humans and animals (15), and the presence of certain microorganisms results in an increased dietary zinc requirement (9).…”

Section: Resultsmentioning

confidence: 97%

“…REDDY et al reported that there was no significant difference between germ-free and con ventional rats in the absorption and net retention of zinc (8). However, SMITH et al suggested that intestinal microflora had some effect on zinc metabolism (9).…”

Section: Observationsmentioning

confidence: 99%

“…However, SMITH et al suggested that intestinal microflora had some effect on zinc metabolism (9). On the other hand, enhanced iron absorption has been reported in pyridoxine-deficient showed that a lack of intestinal microflora resulted in a lower rate of metabolism of iron (8), whereas germ-free rabbits utilized natural sources of iron more efficiently than conventional animals did (11). These findings suggest that the availability of zinc and iron in germ-free animals must have been influenced by the absence of intestinal microflora.…”

Section: Observationsmentioning

confidence: 99%

See 3 more Smart Citations

Observations of the concentration of zinc and iron in tissues of vitamin B6-deficient germ-free rats.

Ikeda

Hosotani

Ueda

et al. 1979

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe transition of zinc and iron metabolism in vitamin B6deficiency was investigated using germ-free and conventional rats.In contrast to previous reports, a decrease in zinc content was not observed in the liver, pancreas, kindney, spleen, lung or testes of vitamin B6-deficient conventional and germ-free rats, but we found an increase in zinc content in the kidney of conventional rats and in the liver and spleen of

show abstract

Section: Resultscontrasting

confidence: 69%

Section: Resultsmentioning

confidence: 97%

Section: Observationsmentioning

confidence: 99%

Section: Observationsmentioning

confidence: 99%

See 2 more Smart Citations

Observations of the concentration of zinc and iron in tissues of vitamin B6-deficient germ-free rats.

Ikeda

Hosotani

Ueda

et al. 1979

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

show abstract

“…A study of seven individuals from a Chinese family provided evidence for this process by demonstrating that relative abundances of Bacteroides, Clostridium, and Bifidobacteria were correlated with the concentrations of urinary metabolites, and variation in the relative abundance of Faecalibacterium prausnitzii was associated with changes in eight urinary metabolites [149]. Germfree rats have also been shown to become anemic when fed a low-iron diet and exhibit increased fecal iron content compared to rats with a healthy microbiota [150].…”

mentioning

confidence: 99%

Co-evolution in context: The importance of studying gut microbiomes in wild animals

Amato

2013

Microbiome Science and Medicine

149

152

View full text Add to dashboard Cite

IntroductionAs sequencing technology makes data generation faster, cheaper, and more comprehensive, studies of gut microbial communities are multiplying at an astonishing rate. As a result, our understanding of the host-gut microbe relationship is constantly improving. Studies to date have demonstrated that the gut microbiota contributes to host nutrition, health and behavioral patterns by providing energy and nutrients, improving immune function, and influencing the production of neuroactive molecules [1][2][3][4][5][6][7][8][9][10][11][12]. Changes in the composition of the gut microbial community are known to lead to changes in its function, which can alter host nutrition, health and behavior [6,[13][14][15][16][17][18][19][20][21][22][23]. Environmental factors such as diet or social contact are largely responsible for determining the composition of the gut microbial community [24][25][26][27][28][29][30][31], but host genotype also affects the abundances of some microbial genera [28,32,33].Because host-gut microbe relationships are influenced to some extent by host genotype, and gut microbial community composition differs according to host phylogeny [34][35][36], discussions of the co-evolution of host and gut microbiota are common in the current literature [7,[34][35][36][37]. Some researchers argue that since microbes are found in animals as simple as earthworms, the co-evolution of animals and bacteria has been Co-evolution in context: The importance of studying gut microbiomes in wild animals Abstract Because the gut microbiota contributes to host nutrition, health and behavior, and gut microbial community composition differs according to host phylogeny, co-evolution is believed to have been an important mechanism in the formation of the host-gut microbe relationship. However, current research is not ideal for examining this theme. Most studies of the gut microbiota are performed in controlled settings, but gut microbial community composition is strongly influenced by environmental factors.To truly explore the co-evolution of host and microbe, it is necessary to have data describing host-microbe dynamics in natural environments with variation in factors such as climate, food availability, disease prevalence, and host behavior. In this review, I use current knowledge of host-gut microbe dynamics to explore the potential interactions between host and microbe in natural habitats. These interactions include the influence of host habitat on gut microbial community composition as well as the impacts of the gut microbiota on host fitness in a given habitat. Based on what we currently know, the potential connections between host habitat, the gut microbiota, and host fitness are great. Studies of wild animals will be an essential next step to test these connections and to advance our understanding of host-gut microbe co-evolution. KeywordsGut microbiota • host-microbe • co-evolution • habitat • ecology • fitness occurring for more than 800 million years [38,39]. Additionally, the increased complexity and stabilit...

show abstract

Impact of micro‐environmental changes on respiratory tract infections with intracellular bacteria

et al. 2016

View full text Add to dashboard Cite

Edited by Wilhelm JustCommunity-acquired pneumonia is caused by intra-and extracellular bacteria, with some of these bacteria also being linked to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease. Chlamydia pneumoniae is an obligate intracellular pathogen that is highly sensitive to micro-environmental conditions controlling both pathogen growth and host immune responses. The availability of nutrients, as well as changes in oxygen, pH and interferon-c levels, have been shown to directly influence the chlamydial life cycle and clearance. Although the lung has been traditionally regarded as a sterile environment, sequencing approaches have enabled the identification of a large number of bacteria in healthy and diseased lungs. The influence of the lung microbiota on respiratory infections has not been extensively studied so far and data on chlamydial infections are currently unavailable. In the present study, we speculate on how lung microbiota might interfere with acute and chronic infections by focusing exemplarily on the obligate intracellular C. pneumoniae. Furthermore, we consider changes in the gut microbiota as an additional player in the control of lung infections, especially in view the increasing evidence suggesting the involvement of the gut microbiota in various immunological processes throughout the human body.

show abstract

Effect of Intestinal Microflora on Iron and Zinc Metabolism, and on Activities of Metalloenzymes in Rats

Cited by 46 publications

References 28 publications

Observations of the concentration of zinc and iron in tissues of vitamin B6-deficient germ-free rats.

Observations of the concentration of zinc and iron in tissues of vitamin B6-deficient germ-free rats.

Co-evolution in context: The importance of studying gut microbiomes in wild animals

Impact of micro‐environmental changes on respiratory tract infections with intracellular bacteria

Contact Info

Product

Resources

About