Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level; implications for meta-analyses and setting vitamin D guidelines

Grant, William B.

doi:10.4161/derm.15364

Cited by 80 publications

(59 citation statements)

References 68 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This reaction generally occurs in late winter or early spring, when serum 25(OH)D levels are lowest. As a result, MS prevalence increases with latitude (Grant, 2010d). A review outlined the evidence that vitamin D reduces the risk of MS (Ascherio et al, 2010).…”

Section: Multiple Sclerosismentioning

confidence: 99%

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Grant

2011

Eur J Clin Nutr

View full text Add to dashboard Cite

Background/Objectives: The goal of this work is to estimate the reduction in mortality rates for six geopolitical regions of the world under the assumption that serum 25-hydroxyvitamin D (25(OH)D) levels increase from 54 to 110 nmol/l. Subjects/Methods: This study is based on interpretation of the journal literature relating to the effects of solar ultraviolet-B (UVB) and vitamin D in reducing the risk of disease and estimates of the serum 25(OH)D level-disease risk relations for cancer, cardiovascular disease (CVD) and respiratory infections. The vitamin D-sensitive diseases that account for more than half of global mortality rates are CVD, cancer, respiratory infections, respiratory diseases, tuberculosis and diabetes mellitus. Additional vitamin D-sensitive diseases and conditions that account for 2 to 3% of global mortality rates are Alzheimer's disease, falls, meningitis, Parkinson's disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis. Increasing serum 25(OH)D levels from 54 to 110 nmol/l would reduce the vitamin D-sensitive disease mortality rate by an estimated 20%. Results: The reduction in all-cause mortality rates range from 7.6% for African females to 17.3% for European females. Reductions for males average 0.6% lower than for females. The estimated increase in life expectancy is 2 years for all six regions. Conclusions: Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.

show abstract

Section: Multiple Sclerosismentioning

confidence: 99%

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Grant

2011

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Beneficial effects of melatonin have also been evaluated in breast cancer. Breast cancer diagnoses have peaks in spring and fall, with the authors suggesting that vitamin D in summer and melatonin in winter reduce the breast tumor growth rate in those seasons 153,154 .…”

Section: Melatonin and Cancermentioning

confidence: 99%

Untitled

2013

IJPSR

View full text Add to dashboard Cite

ABSTRACT:Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search was undertaken in different electronic databases using various search terms. A total of 225 studies were identified including clinical research studies and basic experiments. Data were extracted individually from the studies and compiled in the end. Results: Melatonin has been used successfully in chronic insomnia and as an anti-oxidant in cancer and other age-related neuro-degenerative disorders, especially Alzheimer's disease and Autistic disorders. Its evidences of use in other conditions remained insufficient and inconclusive. Conclusion: Melatonin therapy may be considered as efficacious and safe in insomnia and as an anti-oxidant; however, other roles needs to be evaluated in further studies.

show abstract

“…Estudios ecológicos han mostrado una correlación inversa entre índice de radiación ultravioleta B recibida e incidencia y mortalidad de varios tipos de cáncer, aunque la cuestión siga sometida a discusión 13,14 .…”

unclassified

“Come, calla y ponte al sol”. Del refrán popular al conocimiento de la vitamina D

Crovetto-Martínez

Martínez-Rodríguez

Fernández-Alonso³

2013

Rev Esp Nutr Hum Diet

View full text Add to dashboard Cite

La lengua española es rica en refranes, muchos de los cuales hacen referencia a la alimentación y a la salud. La intención de este artículo es evaluar la certeza de algunos de esos refranes populares que relacionan la salud y la enfermedad con el sol. Se exponen los conocimientos actuales acerca de la vitamina D, su síntesis y sus mecanismos de acción. El profesional de enfermería debe identificar qué sujetos tienen riesgo de hipovitaminosis D, y prevenirla con soluciones nutritivas, ya que la sobreexposición solar no es una medida adecuada debido a los efectos secundarios de la radiación ultravioleta B, lo que contradice el conocimiento derivado de determinados refranes y proverbios españoles clásicos.

show abstract

Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level; implications for meta-analyses and setting vitamin D guidelines

Cited by 80 publications

References 68 publications

An estimate of the global reduction in mortality rates through doubling vitamin D levels

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Untitled

“Come, calla y ponte al sol”. Del refrán popular al conocimiento de la vitamina D

Contact Info

Product

Resources

About