Effect of interstitial chemotherapy with ricin temperature-responsive gel for anti-breast cancer and immune regulation in rats

Chen, Zhikui; Lin, Li; Cai, Jing; Yang, Fengguang; Cai, Hongbo; Xue, Ensheng; Huang, Jing; Wei, Hong-fen; Zhang, Xiujuan

doi:10.1007/s11655-011-0757-4

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Pulchellin, a type 2 RIP isolated from Abrus pulchellus tenuiflorus’ seeds, is a powerful toxin, structurally similar to abrin and ricin. Although the anti-tumor activities and immunomodulatory effects of abrin and ricin have been studied [ 8 - 10 ], there is no such published data for pulchellin.…”

Section: Discussionmentioning

confidence: 99%

Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment

Matos

Ribeiro

Tansini

et al. 2012

BMC Complement Altern Med

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BackgroundRibosome-inactivating proteins (RIP) have been studied in the search for toxins that could be used as immunotoxins for cancer treatment. Pulchellin, a type 2 RIP, is suggested to induce immune responses that have a role in controlling cancer.MethodsThe percentage of dendritic cells and CD4+ and CD8+ T cells in the spleen (flow cytometry), cytokines’ release by PECs and splenocytes (ELISA) and nitric oxide production by PECs (Griess assay) were determined from tumor-bearing mice injected intratumorally with 0.1 ml of pulchellin at 0.75 μg/kg of body weight. Statistical analysis was performed by one-way ANOVA with Tukey’s post hoc test.ResultsPulchellin-treated mice showed significant immune system activation, characterized by increased release of IFN-γ and Th2 cytokines (IL-4 and IL-10), while IL-6 and TGF-β levels were decreased. There was also an increase in macrophage’s activation, as denoted by the higher percentage of macrophages expressing adhesion and costimulatory molecules (CD54 and CD80, respectively).ConclusionsOur results suggest that pulchellin is promising as an adjuvant in breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment

Matos

Ribeiro

Tansini

et al. 2012

BMC Complement Altern Med

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show abstract

Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment

Thapa,

Ali,

Afzal

et al. 2023

J Nanopart Res

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Effect of interstitial chemotherapy with ricin temperature-responsive gel for anti-breast cancer and immune regulation in rats

Abstract: Intratumor injection of ricin temperature-responsive gel showed significant antitumor effect on breast cancer and could enhance the immune function in the tumor-bearing rat.

Cited by 2 publications

References 14 publications

Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment

Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment

Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment

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