Effect of Intermittent Fasting on Carbohydrate, Lipid and Ultrasonographic Parameters in Patients With Non-Alcoholic Fatty Liver Disease and Prediabetes

Abstract

The aim: To study intermittent fasting (IF) treatment in patients with non-alcoholic fatty liver disease (NAFLD) and prediabetes. Materials and methods: Patients with NAFLD (n=95) were examined. The patients were divided into 2 groups: Group 1 – NAFLD with obesity, Group 2 – NAFLD and prediabetes. All patients in both groups had Body mass index (BMI) within the 2nd degree of obesity range (30.0 kg/m2 to 34.5 kg/m2). Results: The effect of IF on anthropometric parameters, carbohydrate and lipid levels in patients with NAFLD with obesity and NAFLD with prediabetes, 6 and 12 months after treatment is shown. Conclusions: Intermittent fasting has a statistically significant effect on anthropometric parameters in NAFLD with obesity and NAFLD with prediabetes. Metformin administration after intermittent fasting in 12 months showed a statistically significant improvement in lipid and carbohydrate profiles.

Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice

“…Human studies are less clear, however, depending on the groups studied. Recent meta-analyses of intermittent fasting studies in MASLD indicated that this intervention reduces body weight, liver enzymes, steatosis, and liver stiffness, particularly in overweight or obese individuals [32][33][34][35][36][37]. Another cross-sectional study reported that an eating window of <8 h was associated with a lower risk of MASLD [38].…”