Effect of interleukin-la, IL-lb and IL-1 receptor antibody on the proliferation and steroidogenesis of regenerating rat adrenal cortex

Zieleniewski, Wojciech; Zieleniewski, J; Stępień, H

doi:10.1055/s-0029-1211381

Cited by 10 publications

(3 citation statements)

References 30 publications

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“…The rest of the glomerulosa is enigmatic, though because of its lack of significant steroidogenic function it has been postulated to be a stem cell population for both glomerulosa and fasciculata cells (Mitani et al 1996, Miyamoto et al 1999, 2001). Here, proof has been elusive, since mitoses can occur throughout the gland (Wright 1971, Horiba et al 1987, McNicol & Duffy 1987, Clark et al 1992, Basile & Holzwarth 1993, Holzwarth 1995, Zieleniewski et al 1995, McEwan et al 1996, Ennen et al 2005, including in the immediate subcapsular region and in the capsule itself (McNeill et al 2005). The possible function of the major, silent, part of the glomerulosa has been discussed elsewhere (Vinson 2003(Vinson , 2004, but taking this evidence at face value, the hypothesis emerges that the glomerulosa is probably not a stem cell population, but may be considered an essentially undifferentiated tissue on to which evolution has grafted some minimal (though crucial) steroidogenic function, in the form of CYP 11B2.…”

Section: Discussionmentioning

confidence: 99%

Eph receptors and zonation in the rat adrenal cortex

Brennan¹,

Chittka²,

Barker³

et al. 2008

Journal of Endocrinology

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Although the zonation of the adrenal cortex has a clear functional role, the mechanisms that maintain it remain largely conjectural. The concept that an outer proliferative layer gives rise to cells that migrate inwards, adopting sequentially the zona glomerulosa, fasciculata and reticularis phenotypes, has yet to be explained mechanistically. In other tissues, Eph receptor (EphR)/ephrin signalling provides a mechanism for cellular orientation and migration patterns. Real-time PCR and other methods were used to determine the possible role of Eph/ephrin systems in the rat adrenal. mRNA coding for several members of the EphR family was detected, but out of these, EphA2 provided the closest parallel to zonal organisation. In situ hybridisation showed that EphA2 mRNA and EphA protein were predominantly located in the zona glomerulosa. Its transcription closely reflected expected changes in the glomerulosa phenotype, thus it was increased after a low-sodium diet, but decreased by pretreatment with the angiotensin-converting enzyme inhibitor, captopril. It was also decreased by ACTH treatment, but unaffected by betamethasone. mRNA coding for ephrin A1, the major ligand for the EphA receptors, was also detected in the rat adrenal, though changes evoked by the various pretreatments did not clearly reflect the expected changes in zonal function. Because the maintenance of cellular zonation requires clear positional signals within the adrenal cortex, these data support a role for Eph forward and reverse signalling in the maintenance of adrenocortical zonation.

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Section: Discussionmentioning

confidence: 99%

Eph receptors and zonation in the rat adrenal cortex

Brennan¹,

Chittka²,

Barker³

et al. 2008

Journal of Endocrinology

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“…Some researches have demonstrated the role of cytokines and their receptors in regulating tumor microenvironment (TME) and different solid tumors formation 10 – 12 . Some researchers have found that5-hydroxytryptamine (5-HT) secreted by mast cells could promote the mRNA expression of aldosterone synthase (CYP11B2) and the secretion of aldosterone 13 , and interleukin-1b (IL-1b) secreted by macrophages has been confirmed to stimulate adrenal cortical cell proliferation 14 , 15 , but only a few previous studies have focused on the correlation of inflammation cytokine levels with APAs, and data regarding cytokine profiling in the APA are merely limited to a small subset of cytokines, which leads to a lack of knowledge about the changes of plasma cytokines in patients with APA and no effective inflammatory factors to detect the presence of this disease.…”

Section: Introductionmentioning

confidence: 99%

“…Some researches have demonstrated the role of cytokines and their receptors in regulating tumor microenvironment (TME) and different solid tumors formation [10][11][12] . Some researchers have found that5hydroxytryptamine (5-HT) secreted by mast cells could promote the mRNA expression of aldosterone synthase (CYP11B2) and the secretion of aldosterone 13 , and interleukin-1b (IL-1b) secreted by macrophages has been confirmed to stimulate adrenal cortical cell proliferation 14,15 , but only a few previous studies have focused on the correlation of inflammation cytokine levels with APAs, and data regarding cytokine profiling in the APA are merely limited to a small subset of cytokines, which leads to a lack of knowledge about the changes of plasma cytokines in patients with APA and no effective inflammatory factors to detect the presence of this disease.The HISTALDO consensus has made new classification in unilateral primary aldosteronism (UPA), and categorised UPA into classic and non-classic histopathological forms 16 , among which the main types of unilateral primary aldosteronism were aldosterone-producing adenoma (APA) as classic histopathological type and unilateral adrenal hyperplasia (UAH) as non-classic histopathological type 1 , which are usually cured by unilateral…”

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confidence: 99%

Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma

Qin

Wen

Zhong

et al. 2023

Sci Rep

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Here, we aimed to study the important cytokines in plasma to identify the aldosterone-producing adenoma (APA). 19 unilateral primary aldosteronism (UPA) patients and 19 healthy people were divided into UPA group and Control group, and the serum of bilateral adrenal veins and inferior vena cava collected by adrenal blood sampling (AVS) in UPA patients and the serum from the healthy subjects were all used to detect multiple cytokines by Luminex immunoassays. Additionally, The UPA patients subjected to laparoscopic adrenalectomy were divided into different groups by pathological results for further study. According our results, IP-10, CXCL9 and RANTES were significantly higher in UPA group compared with control group, and the combination of the three cytokines have significant predictive power for predicting UPA, while the correlational analyses demonstrated that IP-10 and CXCL9 were positively correlated with BP and HR, while EGF was positively correlated with HDL. Additionally, IL-1b was suggested to be the most potential diagnostic biomarker to discriminate the APA and unilateral adrenal hyperplasia (UAH). The present findings might suggest a possibility of IP-10, CXCL9 and RANTES served as a sign to help UPA diagnosis and finally used to assist the diagnosis of APA, while IL-1b was suggested to be the most potential diagnostic biomarker to identify the APA from the UAH patients.

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Adrenocortical zonation and ACTH

Vinson¹

2003

Microscopy Res & Technique

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The clear morphological distinction between the cells of the different adrenocortical zones has attracted speculation and experiment to interpret their functions and the ways in which they are regulated. Considerable data have been produced in recent years that has benefited a fuller understanding of the processes of steroidogenesis and of cell proliferation at the molecular level. This now enables the reexamination of earlier concepts. It is evident that there is considerable species variation, and this article, dealing mainly with the rat, reaches conclusions that do not necessarily apply to other mammals. In the rat adrenal, however, the evidence suggests that the greatest differences between the functions of the zones are between the glomerulosa and the fasciculata. Here the sometimes all-or-nothing demarcation in their complement of components associated with steroidogenesis or with cell proliferation suggests a stark division of labor. In this model the fasciculata is the main engine of steroid hormone output and the glomerulosa is the site of cell proliferation, recruitment, and differentiation. Regulating these functions are angiotensin II and other paracrine components that modulate and maintain the glomerulosa, and ACTH, that maintains the fasciculata, and recruits new fasciculata cells by transformation of proliferating glomerulosa cells. Grafted onto this mostly vegetative function of the glomerulosa is CYP11B2, limited to just a fraction of the outer glomerulosa in rats on a normal laboratory diet and generating aldosterone (and 18-hydroxycorticosterone) from precursors whose origin is not, from the evidence summarized here, very clear, but may include the fasciculata, directly or indirectly. The biosynthesis of aldosterone in the rat certainly requires reinterpretation.

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Effect of interleukin-la, IL-lb and IL-1 receptor antibody on the proliferation and steroidogenesis of regenerating rat adrenal cortex

Cited by 10 publications

References 30 publications

Eph receptors and zonation in the rat adrenal cortex

Eph receptors and zonation in the rat adrenal cortex

Diagnostic accuracy of using multiple cytokines to predict aldosterone-producing adenoma

Adrenocortical zonation and ACTH

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