Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice

Correlation between Clinical/Radiographic Features and Inflammatory Cytokine Networks Produced by Macrophages Stimulated with Endodontic Content

“…In the present study, the individual correlation between the different clinical parameters revealed that the SLR was positively correlated with levels of IL-6, thus confirming its role in bone resorption in chronic inflammatory periodontitis (7,8). Therefore, the presence of exudation in root canals was correlated with higher levels of TNF-a, which is in accordance with previous investigations (20,22,23).…”

“…Furthermore, the ability of IL-6 to induce osteoclast formation and bone resorption (7,8) was observed in its positive correlation with SRL as shown in Table 1. Particularly, when SRL was set as a dependent variable, IL-6 was negatively correlated with IL-1b/PGE 2 production.…”

“…TNF-a stimulates the production of collagenase, prostaglandin E 2 (PGE 2 ), chemoand cytokines, cellular adhesion molecules, and bone resorption-related factors (5,6). IL-6 acts as a proinflammatory cytokine during periodontitis and stimulates osteoclastic differentiation and bone resorption in chronic inflammatory periodontitis (7,8). PGE 2 can induce or repress IL-6 and vice versa (9).…”

C-Reactive Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6

“…IL-6 is induced by IL-1 and tumor necrosis factor alpha during early stages of inflammation, and their effects are synergistic, promoting the recruitment of PMN and monocytes, shifting from acute to chronic inflammation, inducing the expression and activation of matrix Clinical Research metalloproteinase, and stimulating osteoclastogenesis and bone resorption (19,20). Nevertheless, endodontic lesions in IL-6-deficient mice increased in size compared with wild-type mice (20).…”

Protective Effects of Follicle-stimulating Hormone Inhibitor on Alveolar Bone Loss Resulting from Experimental Periapical Lesions in Ovariectomized Rats

“…Those that included the distal root of the first mandibular molars and exhibited a patent root canal apex representing the central portion of the pulp and root canal were selected for staining and being photographed. The areas of periradicular lesions were measured by using a modified template as Balto et al (15) and Huang et al (16) previously described (Fig. 1A).…”