Effect of Interleukin-27 Genetic Variants on Atrial Fibrillation Susceptibility

ChenYu,; ZengJianhui,; Zhang, Rui; ZengLinjun,; LiYajiao,; Weihong,; YangQing,

doi:10.1089/gtmb.2016.0219

Cited by 8 publications

(11 citation statements)

References 22 publications

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“…The association between inflammation and AF has been shown in both animal models and human studies [7], demonstrating increased levels of inflammatory biomarkers such as high-sensitivity C-reactive protein, PTX3, IL-6 [15], as well as IL-27 [16]. It has been shown that high plasma levels of IL-6 are not just correlated with the presence and duration of AF but also with an increased left atrial diameter [17].…”

Section: Resultsmentioning

confidence: 98%

Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study

Lambert¹,

Kong²,

Ratajczak-Tretel³

et al. 2020

Cerebrovasc Dis Extra

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Background and Purpose: Cardioembolic stroke due to paroxysmal atrial fibrillation (AF) may account for 1 out of 4 cryptogenic strokes (CS) and transient ischemic attacks (TIAs). The purpose of this pilot study was to search for biomarkers potentially predicting incident AF in patients with ischemic stroke or TIA. Methods: Plasma samples were collected from patients aged 18 years and older with ischemic stroke or TIA due to AF (n = 9) and large artery atherosclerosis (LAA) with ipsilateral carotid stenosis (n = 8) and age-and sex-matched controls (n = 10). Analyses were performed with the Olink technology simultaneously measuring 184 biomarkers of cardiovascular disease. For bioinformatics, acquired data were analyzed using gene set enrichment analysis (GSEA). Selected proteins were validated using ELISA. Individual receiver operating characteristic (ROC) curves and odds ratios from logistic regression were calculated. A randomForest (RF) model with out-of-bag estimate was applied for predictive modeling. Results: GSEA indicated enrichment of proteins related to inflammatory response in the AF group. Interleukin (IL)-6, growth differentiation factor (GDF)-15, and pentraxin-related protein PTX3 were the top biomarkers on the ranked list for the AF group compared to the LAA group and the control group. ELISA validated increased expression of all tested proteins (GDF-15, PTX3, and urokinase plasminogen activator surface receptor [U-PAR]), except for IL-6. 19 proteins had the area under the ROC curve (AUC) over 0.85 including all of the proteins with significant evolution in the logistic regression. AUCs were very discriminant in distinguishing patients with and without AF (LAA and control group together). GDF-15 alone reached AUC of 0.95. Based on RF model, all selected participants in the tested group were classified correctly, and the most important protein in the model was GDF-15. Conclusions: Our results demonstrate an association between inflammation and AF and that multiple proteins alone and in combination may potentially be used as indicators of AF in CS and TIA patients. However, further studies including larger samples sizes are needed to support these findings. In the ongoing NOR-FIB study, we plan further biomarker assessments in patients with CS and TIA undergoing long-term cardiac rhythm monitoring with insertable cardiac monitors.

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Section: Resultsmentioning

confidence: 98%

Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study

Lambert¹,

Kong²,

Ratajczak-Tretel³

et al. 2020

Cerebrovasc Dis Extra

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“…Previous studies showed that rs153109, rs17855750 and rs181206 of IL27 gene displayed significant associations with dilated cardiomyopathy (DCM) (33), atrial fibrillation (AF) (33), allergic rhinitis (34), pre-eclampsia (35) and renal cell carcinoma (RCC) (36). Thyroid autoimmunity is frequently related to polyglandular endocrine syndromes (37, 38).…”

Section: Discussionmentioning

confidence: 99%

Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases

Wang

et al. 2019

Endocrine Connections

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Background Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs). Methods Three SNPs (rs153109, rs17855750 and rs181206) of IL27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 Graves’ disease (GD) and 327 Hashimoto’s thyroiditis (HT)) and 677 healthy controls in Chinese Han population. Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206. Conclusion Our study, for the first time, showed the significant association of the IL27 gene SNPs with AITD.

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“…Previous clinical studies have reported that elevated IL-12 expression is observed in left atrial tissues of atrial fibrillation patients (Stein et al, 2008;Lappegård et al, 2013). Chen et al found that IL-27 genetic variants, including the rs153109 G allele and GG genotype, increased the occurrence of atrial fibrillation in the Chinese Han population (Chen et al, 2017a).…”

Section: Interleukin-12 Family Members and Atrial Fibrillationmentioning

confidence: 99%

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

Wang

et al. 2020

Front. Pharmacol.

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Cardiovascular diseases represent a complex group of clinical syndromes caused by a variety of interacting pathological factors. They include the most extensive disease population and rank first in all-cause mortality worldwide. Accumulating evidence demonstrates that cytokines play critical roles in the presence and development of cardiovascular diseases. Interleukin-12 family members, including IL-12, IL-23, IL-27 and IL-35, are a class of cytokines that regulate a variety of biological effects; they are closely related to the progression of various cardiovascular diseases, including atherosclerosis, hypertension, aortic dissection, cardiac hypertrophy, myocardial infarction, and acute cardiac injury. This paper mainly discusses the role of IL-12 family members in cardiovascular diseases, and the molecular and cellular mechanisms potentially involved in their action in order to identify possible intervention targets for the prevention and clinical treatment of cardiovascular diseases.

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Effect of Interleukin-27 Genetic Variants on Atrial Fibrillation Susceptibility

Abstract: Our findings indicated that the IL-27 genetic polymorphisms may be associated with susceptibility of AF in Chinese Han population.

Cited by 8 publications

References 22 publications

Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study

Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study

Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases

Roles and Mechanisms of Interleukin-12 Family Members in Cardiovascular Diseases: Opportunities and Challenges

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