Effect of Interleukin-1β on the Behavior of Rats during Mild Stress in the Open-Field Test

Перцов, С. С.; Коплик, Е. В.; As, Simbirtsev; Kalinichenko, L. S.

doi:10.1007/s10517-010-0804-8

Cited by 5 publications

(2 citation statements)

References 7 publications

(9 reference statements)

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“…Behavioral performance was examined using the open-field test, tail suspension test and forced swim test, all of which have been widely used for assessing anxiety and depression of animal in stressful situation [ 35 ]. The locomotor and rearing activities in the open-field test reflect the natural extinction of orientation and exploratory behavior [ 36 , 37 ]. Prolonged immobility time in the tail suspension test and forced swim test reveals a failure of persistence in escape-directed behavior [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains

Wang

Zhou

et al. 2018

PLoS ONE

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Stress has been demonstrated to play an important role in hair follicle function and the pathogenesis of some hair disorders. The central hypothalamic-pituitary-adrenal (HPA) axis is activated by stress stimuli, synthesizes and releases various components and eventually induces the pathogenesis and recurrence of peripheral diseases. Our aim is to compare the different responses under exposure of stress in hair follicle function among different mouse strains, and to detect the involvement of the central HPA axis after stress in hair follicle growth and melanogenesis. In this study, we exposed different mouse strains (C57BL/6, CBA/J, C3H/HeN, BALB/c and ICR) to a 21-day chronic restraint stress protocol and selected C57BL/6, CBA/J and BALB/c mice for further study because of their significant behavioral alterations. Then, we evaluated and compared the different responses and sensitivity to chronic restraint stress in hair follicle function and central HPA axis among the selected strains. The results showed that expression of POMC, CRF and GR mRNA and protein and serum levels of corticosterone were inhibited in response to stress. These findings suggested that chronic restraint stress may inhibit hair follicle growth and melanogenesis via regulating the key elements of the central HPA axis. In addition, the results revealed different mouse strains exhibit different responses in the central HPA axis and hair follicle after stress exposure. C57BL/6 might be the most sensitive strain among the three strains tested as well as an appropriate strain to study possible pathophysiological mechanisms by which the nervous system influences skin function and screen dermatological drugs suitable for psychotherapy. We believe the current study will provide some useful information for researchers who are interested in the bidirectional communication between the nervous and skin systems and the management of stress-induced cutaneous diseases.

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Section: Discussionmentioning

confidence: 99%

Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains

Wang

Zhou

et al. 2018

PLoS ONE

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“…The open field test is a well-known test for behavioral analysis, which has been used for several decades [ 21 , 22 ]. Even though the test is not absolutely specific, it is a good tool to quantify well-being [ 23 , 24 ]. In former analyses, we could already demonstrate the usability of the test to evaluate well-being in PDAC [ 11 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being

Hirth

Xie

Höper

et al. 2022

Cells

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In addition to the poor prognosis, excruciating abdominal pain is a major challenge in pancreatic cancer. Neurotropism appears to be the underlying mechanism leading to neuronal invasion. However, there is a lack of animal models suitable for translationally bridging in vitro findings with clinical trials. We characterized KPC (KrasG12D/+; Trp53R172H/+; P48-Cre) and KPPC (KrasG12D/+; Trp53R172H/R172H; P48-Cre) mice with genetically determined pancreatic ductal adenocarcinoma (PDAC) and compared them with an orthotopic pancreatic cancer mouse model, healthy littermates and human tissue. We analyzed behavioral correlates of cancer-associated pain and well-being, and studied neuronal remodeling and cytokine expression. Histologically, we found similarities between KPC and KPPC tissue with human samples. Compared to healthy littermates, we detect nerve fiber hypertrophy, which was not restricted to a certain fiber type. Interestingly, while KPPC mice showed significantly reduced well-being, KPC mice emerged to be better suited for studying long-lasting cancer pain that emerges over a slow course of tumor progression. To address the neuroinflammatory correlate of loss of well-being, we studied cytokine levels in KPPC mice and observed a significant upregulation of CXCL16, TNFRSF5, CCL24, CXCL1, CCL22, CLL20 and CX2CL1. In summary, we demonstrate that the KPC mouse model is best suited to studying cancer pain, whereas the KPPC model can be employed to study cancer-associated reduction in well-being.

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Dynamics of Blood Cytokine Concentrations in Rats with Different Behavioral Characteristics after Acute Stress

Перцов

Kalinichenko²,

Коплик³

et al. 2016

Neurosci Behav Physi

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Effect of Interleukin-1β on the Behavior of Rats during Mild Stress in the Open-Field Test

Cited by 5 publications

References 7 publications

Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains

Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains

Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being

Dynamics of Blood Cytokine Concentrations in Rats with Different Behavioral Characteristics after Acute Stress

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