Effect of interleukin-17 on gene expression profile of fibroblasts from Crohn's disease patients

Kerami, Zohra; Duijvis, Nicolette W.; Vogels, Esther; Dooren, Faas H. van; Moerland, Perry D.; Velde, Anje A. te

doi:10.1016/j.crohns.2014.02.009

Cited by 28 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertrophic scars and keloids may be a consequence of cutaneous injury as in acne and are associated with upregulation of many proinflammatory cytokines on histopathological examinations . IL‐17 was found to induce the expression of multiple inflammation‐associated genes such as IL‐8, IL‐6, intercellular adhesion molecule (ICAM)‐1, and granulocyte/macrophage‐colony stimulating factor (GM‐CSF) and to stimulate CXCL1, CXCL2, CXCL5, and CXCL8 in human epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…limited data about acne scars pathogenesis suggested us to investigate and compare the serum level of IL-17 between scarring and nonscarring acne patients. Serum IL-17 concentrations were significantly higher in scarring acne patients when compared to those without acne scars.Hypertrophic scars and keloids may be a consequence of cutaneous injury as in acne and are associated with upregulation of many proinflammatory cytokines on histopathological examinations 22. IL-17 was found to induce the expression of multiple inflammationassociated genes such as IL-8, IL-6, intercellular adhesion molecule (ICAM)-1, and granulocyte/macrophage-colony stimulating factor (GM-CSF) and to stimulate CXCL1, CXCL2, CXCL5, and CXCL8 in human epithelium.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Serum interleukin‐17 as a novel biomarker in patients with acne vulgaris

Ebrahim

Mustafa

El-Abd

2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Acne vulgaris is a common chronic inflammatory skin disease involving pilosebaceous units. Both innate and adaptive immunity, especially the T helper 17 pathway, may contribute to the inflammatory response in acne. Objectives We aimed at evaluation of serum interleukin‐17 (IL‐17) level in patients with acne vulgaris in order to assess its role in disease pathogenesis and its clinical significance. Methods Serum IL‐17 level was measured by an ELISA technique in 80 acne vulgaris patients and 80 apparently healthy controls. Results Serum IL‐17 level was significantly higher in acne vulgaris patients than control group (P < 0.001). Moreover, it was increasing significantly with the increase in disease severity and in patients with scarring lesions (P < 0.001 each). Conclusions Serum IL‐17 is not only a biomarker of disease pathogenesis but also it could be a potential prognostic predictor for severity and scarring in acne vulgaris.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Serum interleukin‐17 as a novel biomarker in patients with acne vulgaris

Ebrahim

Mustafa

El-Abd

2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…Although crucial in protecting the host from invasion by many types of pathogens, dysregulated IL-17A production can result in excessive proinflammatory cytokine expression and chronic inflammation, which lead to tissue damage and autoimmunity. IL-17 family cytokines have been linked to many autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis (RA), inflammatory bowel disease, and psoriasis [6,9,15,20].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

Shao-ru

Liu

et al. 2014

Inflammation

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly populations worldwide. Inflammation, among many factors, has been suggested to play an important role in AMD pathogenesis. Interleukin 17 (IL-17) is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. In the current study, we examined two single nucleotide polymorphisms (SNPs), rs2275913G/A and rs3748067C/T, in the IL-17A gene between AMD patients and healthy controls. Results showed that rs2275913AA genotype and rs3748067TT genotype were associated with increased susceptibility to AMD (hazard ratio [HR], 1.75; 95 % confidence interval [CI], 1.07 to 3.02; P=0.023, and HR, 2.12; 95 % CI, 1.26 to 4.01; P=0.004; data were adjusted for age and sex). Next, we investigated the functional relevance of the two SNPs. In vitro stimulated peripheral blood mononuclear cells (PBMCs) from subjects possessing the rs2275913AA genotype produced significantly more IL-17 than those with the GG genotype. However, PBMCs with rs3748067TT genotype revealed significantly higher IL-17 production than those with rs3748067CC genotype only in AMD patients but not in controls. These data indicate IL-17A polymorphisms are associated with increased risk of AMD probably by affecting gene expression.

show abstract

“…In patients with ulcerative colitis, the expression of lipocalin-2, an essential marker of activity of the disease, is regulated synergically by IL17-A, IL22 and TNFα in an IκBζ-dependent manner [ 76 , 77 ]. Likewise, an important role of IκBζ was highlighted in various autoimmune diseases, for example in Sjögren's syndrome-like disease [ 78 ], Crohn's disease [ 79 ], rhumatoid arthritis [ 80 ] as well as in psoriasis. For this last disease, a new susceptibility DNA polymorphism (rs7637230, G→A) was found at a locus adjacent to NFKBIZ [ 81 ].…”

Section: Iκbζmentioning

confidence: 99%

IκBζ: an emerging player in cancer

et al. 2016

View full text Add to dashboard Cite

IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival. As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies.

show abstract

Effect of interleukin-17 on gene expression profile of fibroblasts from Crohn's disease patients

Abstract: The enhanced expression of IL-17 that is observed in patients with Crohn's disease could act on intestinal fibroblasts to induce expression of transcription factor NFKBIZ and proinflammatory chemokine CXCL1. This can have consequences for fibroblast activity and neutrophil chemotaxis.

Cited by 28 publications

References 31 publications

Serum interleukin‐17 as a novel biomarker in patients with acne vulgaris

Serum interleukin‐17 as a novel biomarker in patients with acne vulgaris

Genetic Variants of Interleukin 17A Are Functionally Associated with Increased Risk of Age-Related Macular Degeneration

IκBζ: an emerging player in cancer

Contact Info

Product

Resources

About