Effect of interaction between obesity-promoting genetic variants and behavioral factors on the risk of obese phenotypes

Rana, Sobia; Sultana, Ayesha; Bhatti, Adil Anwar

doi:10.1007/s00438-021-01793-y

Cited by 10 publications

(15 citation statements)

References 101 publications

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“…The cross-sectional study was excluded to ensure the strength of evidence was not overestimated, and the most recent longitudinal study was included. In total, 18 studies met the PECOS criteria and were included in this review (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46). Figure 1 shows the PRISMA flow chart for the selection of studies.…”

Section: Resultsmentioning

confidence: 99%

“…Rahati et al (n = 403) reported in a crosssectional study that for carriers of Circadian Locomotor Output Cycles Kaput (CLOCK) gene polymorphisms, delayed eating times for breakfast and lunch increased the odds of obesity by 2.95 (95% CI = 1.77, 4.90) and 1.53 (95% CI = 1.32, 1.89) respectively after adjustment for age, sex and 6 other confounders (36). Significant interactions between risk alleles in multiple genes, including FTO, MC4R, and transmembrane protein 18 (TMEM18) and random eating patterns were also found to increase BMI (P interaction =0.002, P interaction = 0.008, P interaction =0.001 respectively) in the case-control study by Rana et al (n = 578) focussing on a Pakistani population after age and sex adjustment (37).…”

Section: Association Studies Diet and Food Timingmentioning

confidence: 94%

“…Both studies demonstrated unfavourable outcomes on obesity traits in response to the interaction between genetic variants and reduced sleeping times. In a Pakistani population (n = 578), Rana et al applied a case-control study design to demonstrate a significant interaction between TMEM18, neuronal growth regulator 1 (NEGR1), FTO and MC4R gene variants and irregular sleep-wake cycle, which was shown to augment BMI, WC, HC, WHR, WHtR and %BF, in carriers of risk alleles after controlling for age and sex (37). In the same study, inadequate sleep, defined as <7 hours/night, was also shown to interact with FTO, TMEM18 and NEGR1 gene variants to increase BMI and WC significantly.…”

Section: Sleeping Patternsmentioning

confidence: 99%

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Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review

Pledger,

Ahmadizar

2023

Front. Endocrinol.

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BackgroundObesity represents a major and preventable global health challenge as a complex disease and a modifiable risk factor for developing other non-communicable diseases. In recent years, obesity prevalence has risen more rapidly in low- and middle-income countries (LMICs) compared to high-income countries (HICs). Obesity traits are shown to be modulated by an interplay of genetic and environmental factors such as unhealthy diet and physical inactivity in studies from HICs focused on populations of European descent; however, genetic heterogeneity and environmental differences prevent the generalisation of study results to LMICs. Primary research investigating gene-environment interactions (GxE) on obesity in LMICs is limited but expanding. Synthesis of current research would provide an overview of the interactions between genetic variants and environmental factors that underlie the obesity epidemic and identify knowledge gaps for future studies.MethodsThree databases were searched systematically using a combination of keywords such as “genes”, “obesity”, “LMIC”, “diet”, and “physical activity” to find all relevant observational studies published before November 2022.ResultsEighteen of the 1,373 articles met the inclusion criteria, of which one was a genome-wide association study (GWAS), thirteen used a candidate gene approach, and five were assigned as genetic risk score studies. Statistically significant findings were reported for 12 individual SNPs; however, most studies were small-scale and without replication.ConclusionAlthough the results suggest significant GxE interactions on obesity in LMICs, updated robust statistical techniques with more precise and standardised exposure and outcome measurements are necessary for translatable results. Future research should focus on improved quality replication efforts, emphasising large-scale and long-term longitudinal study designs using multi-ethnic GWAS.

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Section: Resultsmentioning

confidence: 99%

Section: Association Studies Diet and Food Timingmentioning

confidence: 94%

Section: Sleeping Patternsmentioning

confidence: 99%

See 1 more Smart Citation

Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review

Pledger,

Ahmadizar

2023

Front. Endocrinol.

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“…Scientific evidence supports an interaction between PA and genetic background on obesity disposition, including evidence on the attenuating effect of PA on TMEM18 obesity predisposition. Yet, specific genetic polymorphisms with a sensitivity to PA which are able to modify obesity risk remain widely unknown [ 27 , 28 ]. The biological mechanisms that underlie the attenuation of TMEM18 ’s effect in physically active individuals, and whether the interaction is due to PA or due to other environmental exposures remain unclear [ 27 , 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Yet, specific genetic polymorphisms with a sensitivity to PA which are able to modify obesity risk remain widely unknown [ 27 , 28 ]. The biological mechanisms that underlie the attenuation of TMEM18 ’s effect in physically active individuals, and whether the interaction is due to PA or due to other environmental exposures remain unclear [ 27 , 28 , 29 , 30 ]. In this research, we further support the critical importance of PA as a weight loss-promoting behavior, as well as a prevention strategy of weight gain with an adequate regime that needs to be incorporated into clinical interventions for weight control with special attention given to TMEM18 variant carriers.…”

Section: Discussionmentioning

confidence: 99%

Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers

Chermon

Birk²

2023

Nutrients

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The transmembrane protein 18 (TMEM18) gene plays a central and peripheral role in weight regulation. TMEM18 genetic polymorphisms have been identified as an important risk factor for obesity, depending on ethnic population and age. This research aimed to study the association of common TMEM18 polymorphisms with obesity and their interactions with modifiable factors, namely drinking habits (sugar-sweetened beverages (SSBs), flavored water and wine) and physical activity (PA) in the Israeli population. Adults (n = 3089) were analyzed for common TMEM18 polymorphisms and lifestyle and nutrition habits were obtained from questionnaires using adjusted (age, sex) binary logistic regression models. TMEM18 rs939583 and rs1879523 were significantly associated with increased obesity risk (OR = 1.35, 95% CI (1.17–1.57) and OR = 1.66, 95% CI (1.29–2.15), respectively). TMEM18 rs939583 interacted with consumption of 1–3 weekly glasses of wine and PA to attenuate obesity risk (OR = 0.82 95% CI (0.74–0.9; p < 0.001) and OR = 0.74 95% CI (0.68–0.8), respectively), while physical inactivity, SSBs and flavored water consumption significantly enhanced obesity risk (OR = 1.54 95% CI (1.41–1.67), OR = 1.31 95% CI (1.14–1.51) and OR = 1.35 95% CI (1.13–1.62), respectively). PA duration was significantly associated with a lower BMI for rs939583 risk carriers, with a PA cutoff of >30 min/week (p = 0.005) and >90 min/week (p = 0.01). Common TMEM18 SNPs were significantly linked with adult obesity risk and interacted with modifiable lifestyle factors.

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Psychometric properties of the toddler feeding style questionnaire in fathers and its gender invariance

Lozano-Casanova,

Escribano,

Oliver-Roig

et al. 2024

Appetite

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Effect of interaction between obesity-promoting genetic variants and behavioral factors on the risk of obese phenotypes

Cited by 10 publications

References 101 publications

Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review

Gene-environment interactions and the effect on obesity risk in low and middle-income countries: a scoping review

Drinking Habits and Physical Activity Interact and Attenuate Obesity Predisposition of TMEM18 Polymorphisms Carriers

Psychometric properties of the toddler feeding style questionnaire in fathers and its gender invariance

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