Effect of intake pattern of sulfated polysaccharides on its biological activity in high fat diet-fed mice

Liu, Yili; Ma, Na; Sun, Xiao; Duan, Mengmeng; Luo, Tengrui; Jiang, Pingrui; Jiang, Guoping; Song, Shuang; Ai, Chunqing

doi:10.1016/j.ijbiomac.2019.03.174

Cited by 20 publications

(13 citation statements)

References 41 publications

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“…MSPs from Cymodocea nodosa effectively reduced weight and inhibited lipase activity in obese mice [21], and MSPs from brown seaweed Ascophyllum nodosum could pass through the upper digestive tract and could be degraded by gut microbe, thus regulating the composition of gut microbiota and reducing the risk of obesity [22]. MSPs of abalone gonad could improve the metabolic syndrome and gut microbiota dysbiosis induced by high fat diet and could affect nutrient absorption and energy metabolism [23]. SP from sea cucumber has a good therapeutic effect on dietinduced obesity mice; it could reduce the levels of fat, serum lipid and inflammatory cytokines, and had a good preventive effect on metabolic syndrome [24].…”

Section: Obesitymentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

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Section: Obesitymentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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“…And the methods of NDPs preparation should be simpler, and economic for industrial production. Finally, consumption pattern [134] and dosage also influence the effectiveness of the NDPs. More toxicological studies are needed to find the optimal dose for clinical application.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Behavior of Non‐Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti‐Obesity Effect

Zhang

Xie

You

et al. 2021

eFood

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Nowadays, obesity in humans is a huge challenge requiring effective, readily available, and low-risk alternative treatments. Intake of edible Non-Digestible Polysaccharides (NDPs) is regarded as a promising strategy to combat obesity. Herein, an overview of the behavior of NDPs in the Gastrointestinal (GI) tract and its association with anti-obesity effect is summarized. Both the in vitro and in vivo of such investigations are discussed. Results show that NDPs can reach the large intestine to mediate the gut microbiota with the extent of regulation varies among NDPs with different chemical structures. The possible anti-obesity mechanisms associated with behavior of NDPs in the GI tract include: (i) inhibition of fat absorption, (ii) modification of gut microbiota and their metabolites such as short-chain fatty acids, (iii) regulation of bile acid profiles, (iv) modulation on appetite and satiety effect, and (v) protection of intestinal barrier. However, more efforts are required to clarify the exact behavior and their beneficial effects of NDPs within GI tract. This paper will provide an overlook of recent advances for better understanding anti-obesity activity of NDPs.

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“…PS have been shown to be good antiviral agents, health foods, antioxidants, anti-inflammatory, and immunomodulatory compounds, and they can also be used as lubricants for bone joints and drag-reducing substances for ships [62]. sPS from marine sources exhibited, in particular, immunomodulatory activities [2,[63][64][65][66][67][68][69], and are promising candidates for drug development. sSP have been found in several macroalgae and microalgae, in both marine and freshwater environments, such as in the green alga Monostroma nitidum [70], the red algae Gelidum corneum [67] and Gracilaria caudata [71], the diatom P. tricornutum [23], the dinoflagellate G. impudicum, the freshwater xanthophycea Tribonema sp.…”

Section: Sulfate Polysaccharidesmentioning

confidence: 99%

Microalgae with Immunomodulatory Activities

2019

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Microalgae are photosynthetic microorganisms adapted to live in very different environments and showing an enormous biochemical and genetic diversity, thus representing an excellent source of new natural products with possible applications in several biotechnological sectors. Microalgae-derived compounds have shown several properties, such as anticancer, antimicrobial, anti-inflammatory, and immunomodulatory. In the last decade, compounds stimulating the immune system, both innate immune response and adaptive immune response, have been used to prevent and fight various pathologies, including cancer (cancer immunotherapy). In this review we report the microalgae that have been shown to possess immunomodulatory properties, the cells and the cellular mediators involved in the mechanisms of action and the experimental models used to test immunostimulatory activities. We also report information on fractions or pure compounds from microalgae identified as having immunostimulatory activity. Given the increasing interest in microalgae as new eco-friendly source of bioactive compounds, we also discuss their possible role as source of new classes of promising drugs to treat human pathologies.

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Effect of intake pattern of sulfated polysaccharides on its biological activity in high fat diet-fed mice

Cited by 20 publications

References 41 publications

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Behavior of Non‐Digestible Polysaccharides in Gastrointestinal Tract: A Mechanistic Review of its Anti‐Obesity Effect

Microalgae with Immunomodulatory Activities

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