Effect of insulin treatment on plasma oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients

Galland, F.; Duvillard, Laurence; Petit, J.-M.; Lagrost, Laurent; Vaillant, G.; Brun, JM; Gambert, Philippe; Vergès, Bruno

doi:10.1016/s1262-3636(07)70318-x

Cited by 24 publications

(13 citation statements)

References 42 publications

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“…Decreased levels of serum TGs and small augmented levels of serum HDL and adiponectin have been reported in subjects with type 2 diabetes after insulin therapy interventions. 42,43 However, the functionality rather than the level of HDL per se has recently been shown to be important for the protective effects of HDL with respect to CVD risk. 44 In contrast, the causative role of non-HDL in CVD development remains established.…”

Section: Discussionmentioning

confidence: 99%

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes

Skovsø¹,

Damgaard

Fels

et al. 2015

Int J Obes

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Section: Discussionmentioning

confidence: 99%

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes

Skovsø¹,

Damgaard

Fels

et al. 2015

Int J Obes

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“…Ox-LDL was not significantly different, but ox-LDL to LDL ratio was significantly different among groups with VC and without VC in our study. Ox-LDL to LDL ratio, an accurate estimation of in vivo LDL oxidation (23), indicates an environment of oxidative stress in HD patients with relatively low LDL levels. Thus, we suggest that the formation of medial artery calcification on the plain radiograph of feet may be affected by oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Associations between Oxidized LDL to LDL Ratio, HDL and Vascular Calcification in the Feet of Hemodialysis Patients

Kim

et al. 2009

J Korean Med Sci

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Cardiovascular mortality is associated with vascular calcification (VC) in hemodialysis (HD) patients. The present study was designed to find factors related with medial artery calcification on the plain radiography of feet by comparing C-reactive protein (CRP), plasminogen activator inhibitor type 1 (PAI-1) and lipid profile including oxidized low density lipoprotein (ox-LDL) and to elucidate associations among these factors in HD patients. Forty-eight HD patients were recruited for this study. VC in the feet was detected in 18 patients (37.5%) among total patients and 12 patients (85.7%) among diabetic patients. Diabetes, cardiovascular disease (CVD), pulse pressure, ox-LDL/LDL were higher and high density lipoprotein (HDL) was lower in patients with VC than in patients without VC. Negative associations were found between HDL and CRP, PAI-1. PAI-1 had positive association with ox-LDL/LDL. History of CVD was the only determinant of vascular calcification on the plain radiography of feet. Ox-LDL/LDL, HDL, CRP, and PAI-1 were closely related with one another in HD patients. History of CVD is the most important factor associated with the presence of VC and low HDL and relatively high oxidized LDL/LDL ratio may affect VC formation on the plain radiography in the feet of HD patients.

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“…Clearly, oxLDL does exert beneficial effects in some diseases, at least in certain stage of the disease progression. Although circulating LDL and oxLDL levels were increased in type 2 diabetic patients (43,44) and reduced after control of hyperglycemia (45), their precise roles in the pathogenesis of diabetes still remains unclear. The possibility that an increase in serum LDL and subsequent oxLDL levels is a protective response to hyperglycemia, at least in certain stage of diabetes, can not be precluded.…”

Section: Discussionmentioning

confidence: 99%

DrugPattern: a web-based tool for drug set enrichment analysis

Huang

Yang

Wang

et al. 2017

Preprint

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Set enrichment analysis based methods (e.g. gene set enrichment analysis) have provided great helps in mining patterns in biomedical datasets, however, tools for inferring regular patterns in drug-related datasets are still limited. For the above purpose, here we developed a web-based tool, DrugPattern. DrugPattern first collected and curated 7019 drug sets, including indications, adverse reaction, targets, pathways etc. For a list of interested drugs,

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Effect of insulin treatment on plasma oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients

Cited by 24 publications

References 42 publications

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes

Associations between Oxidized LDL to LDL Ratio, HDL and Vascular Calcification in the Feet of Hemodialysis Patients

DrugPattern: a web-based tool for drug set enrichment analysis

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