Effect of Insulin Therapy on Renal Changes in Spontaneously Diabetic Torii Rats

Ohta, Takeshi; Matsui, Kenichi; Miyajima, Katsuhiro; Sasase, Tomohiko; Masuyama, Taku; Shoda, Toshiyuki; Koizumi, Haruko; Shinohara, Masami; Matsushita, Mutsuyoshi

doi:10.1538/expanim.56.355

Cited by 41 publications

(49 citation statements)

References 25 publications

(32 reference statements)

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“…4). Nodular lesions in SDT normal rats have been observed at 68 weeks of age [14]. SD rats have not shown renal lesions from at ages younger than 68 weeks of age [14].…”

Section: Discussionmentioning

confidence: 87%

“…Nodular lesions in SDT normal rats have been observed at 68 weeks of age [14]. SD rats have not shown renal lesions from at ages younger than 68 weeks of age [14]. Renal histological lesions of the glomerulus and tubule in ZDF rats were observed after 20 weeks of age [2,17].…”

Section: Discussionmentioning

confidence: 91%

“…6). Moreover, SD rats have not shown ocular changes before 68 weeks of age [14]. The histopathological features of cataract were not different between the SDT fatty rat and the SDT normal rat, whereas the pathological degree was more progressed in the SDT fatty rat.…”

Section: A B C Dmentioning

confidence: 81%

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Diabetes-Associated Complications in Spontaneously Diabetic Torii Fatty Rats

et al. 2008

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“…4). Nodular lesions in SDT normal rats have been observed at 68 weeks of age [14]. SD rats have not shown renal lesions from at ages younger than 68 weeks of age [14].…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 91%

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Diabetes-Associated Complications in Spontaneously Diabetic Torii Fatty Rats

et al. 2008

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“…In SDT rats, development of hyperglycemia may be more dependent on decreased insulin secretion than insulin resistance, as shown by the fact that the blood insulin concentration tended to be lower than in normal SD rats even before the onset of diabetes, and marked hypoinsulinemia developed after the onset of hyperglycemia [91][92][93], indicating that this strain of rat is a model of non-obese T2D associated with impaired insulin secretion. It is clinically known that glucose tolerance decreases before the onset of T2D.…”

Section: Glucose Tolerance and Insulin Sensitivitymentioning

confidence: 99%

Non-Obese Type 2 Diabetes Animals Models

Ishii¹,

Ohta²,

Sasase³

2012

Glucose Tolerance

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“…SDT rats also develop ocular complications (cataract and retinopathy) and nephropathy from about 40 weeks of age [24]. Sasase et al have reported that the lesions in SDT rats are induced by hyperglycemia because an improvement is observed following continuous subcutaneous insulin administration [14,20]. Therefore, the SDT rat is expected to be useful as a new animal model of diabetes-associated complications such as retinopathy and nephropathy.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Function of Spontaneously Diabetic Torii Rats in Pre-Diabetic Stage

et al. 2009

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Abstract:The Spontaneously Diabetic Torii (SDT) rat is a new model for non-obese type 2 diabetes. In the present study, we investigated changes in insulin secretion from the pancreas of male SDT rats aged 8, 16, and 24 weeks in order to analyze pancreatic function. An analysis of glucose-stimulated insulin secretion (GSIS) in isolated islets showed a marked reduction in insulin secretion in pre-diabetic 16-week-old SDT rats. When the islets were treated with tolbutamide or glucagon-like peptide-1 (7-36) amide (tGLP-1) in the presence of 11.2 mM glucose, however, insulin levels were restored to levels of normal rats. In vivo study, SDT rats exhibited a marked reduction in GSIS from 16 weeks of age. However, tolbutamide or JTP-76209, which is a novel dipeptidyl peptidase IV (DPP IV) inhibitor, increased insulin release after glucose loading and improved glucose tolerance. A marked reduction in GSIS was observed in pre-diabetic SDT rats and the reduction was improved by tolbutamide, tGLP-1, and the DPP IV inhibitor. Therefore, we concluded that the SDT rat is useful, as a model of non-obese insulin secretory disorder, for the analysis of the onset of type 2 diabetes and the development of antidiabetic agents.

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Effect of Insulin Therapy on Renal Changes in Spontaneously Diabetic Torii Rats

Abstract: The spontaneously diabetic Torii (SDT) rat has recently been established as an animal model of non-obese type 2 diabetes, in which ocular

Cited by 41 publications

References 25 publications

Diabetes-Associated Complications in Spontaneously Diabetic Torii Fatty Rats

Diabetes-Associated Complications in Spontaneously Diabetic Torii Fatty Rats

Non-Obese Type 2 Diabetes Animals Models

Pancreatic Function of Spontaneously Diabetic Torii Rats in Pre-Diabetic Stage

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