Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure: a preliminary report

Takei, Izumi; Takayama, Sumiyo; Yamauchi, Akira; Nakamoto, S.; Kitamura, Yuko; Katsukawa, Fuminori; Yamazaki, Hajime; Saruta, Takao; Inoue, Sachika

doi:10.1038/sj.ejcn.1600506

Cited by 10 publications

(10 citation statements)

References 6 publications

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“…After starting insulin therapy in T2D, Takei at al. [36] observed a similar trend, i.e., a significant decrease in the ratio of visceral-to-subcutaneous fat area, this was mainly due to an increase in the subcutaneous fat amounts. The changes of skinfold thicknesses in upper body in women, were not statistically significant, which is most likely related to physiologically lower activity of lipoprotein lipase (LPL) adipocytes in this area [37] as per oestrogen effect, compared to men, in which LPL adipocyte activity in abdominal SAT is higher [24].…”

Section: Discussionsupporting

confidence: 54%

Insulin Pump Therapy – Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients

et al. 2018

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Background: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII). Methods: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. Results: In both sexes, we found an increase in skeletal muscle mass (SMM), (p = 0.008; 0.008). In men, there was mainly a decrease in visceral fat area (VFA), (p = 0.028) and in women there was decrease of total body fat (TBF), (p = 0.020) and non-significant decrease of VFA (p = 0.098). SMM inversely correlated with VFA in men (p = –0.001) and with TBF in women (p = –0.005 ). GV was decreased generally and correlated inversely with TBF in men only (p = –0.026). Physical activity was increased and correlated inversely with VFA in men (p = –0.002) and in women (p = –0.006). Conclusions: Using CSII in T1D leads to a significant increase of SMM in both sexes to a decrease of VFA in men and to a non-significant decrease of VFA in women. Changes in adipose tissue and SMM were also related to increased physical activity and to decreased GV.

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Section: Discussionsupporting

confidence: 54%

Insulin Pump Therapy – Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients

et al. 2018

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“…34 Other human studies demonstrated no effect of insulin therapy on VAT. 10,31,33 We favour the idea that insulin's effects are direct on adipose tissue. We have not observed hypoglycaemia or hyperphagia in this model.…”

Section: Discussionmentioning

confidence: 89%

“…31,32 Our observation that insulin therapy resulted in elevated levels of SAT in HF/HS-STZ rats also agrees with data from some human studies. 32,33 However, three other clinical studies observed no change in SAT after insulin therapy. 10,31,34 We observed an insulin-induced increase in VAT, which likewise has been reported in human studies.…”

Section: Discussionmentioning

confidence: 97%

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes

Skovsø¹,

Damgaard

Fels

et al. 2015

Int J Obes

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“…Previous studies have shown that the increased fat mainly accumulates in subcutaneous sites, while changes in visceral fat and muscle mass after insulin therapy are inconclusive (22)(23)(24). Furthermore, no studies have examined whether the alterations in body fat distribution and skeletal muscle mass after early intensive insulin therapy are related to improved glycemic control and insulin sensitivity in newly diagnosed type 2 diabetes patients.…”

Section: Discussionmentioning

confidence: 93%

The Effect of Early Intensive Insulin Therapy on Body Fat Distribution andβ-Cell Function in Newly Diagnosed Type 2 Diabetes

et al. 2013

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Objectives. The aim of this study was to evaluate the effects of early intensive insulin therapy on body fat distribution, lean body mass and β-cell function in patients with newly diagnosed type 2 diabetes. Methods. Thirty-eight subjects with newly diagnosed type 2 diabetes participated in a 12-week course of intensive insulin therapy. Patients were administered a 75 g oral glucose tolerance test (OGTT), underwent measurement of visceral and subcutaneous adipose tissues (VAT and SAT) using computed tomography and appendicular skeletal muscle (ASM) mass was assessed using dual-energy X-ray absorptiometry. Results. After intensive insulin therapy, fasting plasma glucose and HbA1c levels decreased. Homeostasis model assessment (HOMA)-B, the insulinogenic index, and the C-peptide-to-glucose area under the curve (AUC) ratio increased. The insulin sensitivity index and the glucose AUC decreased after 12 weeks. The body composition analysis revealed that the VAT and the ratio of VAT to SAT decreased, whereas body weight and total fat mass increased nonsignificantly. The ASM/weight and skeletal muscle mass index increased. The restoration of β-cell function, as identified by HOMA-B, the insulinogenic index, and the C-peptide-to-glucose AUC ratio, was correlated with the changes in VAT when controlled for age and gender. In multiple regression analyses, the decrease in VAT was shown to independently contribute to improved HbA1c over the study period, after adjusting for confounding factors. Conclusions. These results suggest that a shift in fat distribution from visceral to subcutaneous fat after early intensive insulin therapy is associated with improvements in glycemic control and β-cell function in patients with newly diagnosed type 2 diabetes.

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Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure: a preliminary report

Cited by 10 publications

References 6 publications

Insulin Pump Therapy – Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients

Insulin Pump Therapy – Influence on Body Fat Redistribution, Skeletal Muscle Mass and Ghrelin, Leptin Changes in T1D Patients

Effects of insulin therapy on weight gain and fat distribution in the HF/HS-STZ rat model of type 2 diabetes

The Effect of Early Intensive Insulin Therapy on Body Fat Distribution andβ-Cell Function in Newly Diagnosed Type 2 Diabetes

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