Effect of insulin and phenobarbital on uptake of 2‐deoxyglucose by brain slices and hemidiaphragms

Philips, M. E.; Coxon, R. V.

doi:10.1111/j.1471-4159.1976.tb12299.x

Cited by 31 publications

(7 citation statements)

References 16 publications

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“…In contrast, ICV insulin increases the activities of these enzymes . Phillips and Coxon (1976) reported increased glucose utilization by brain slices from young rats after insulin administration. Transfection of Chinese hamster ovary cells with the expression vector containing rabbit brain HepG2-type glucose transporter cDNA respond to insulin application with more than 40% increase in deoxyglucose uptake (Asano et al, 1989).…”

Section: Discussionmentioning

confidence: 96%

Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats

et al. 2006

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Section: Discussionmentioning

confidence: 96%

Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats

et al. 2006

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“…In brain slices, an insulinmediated increase of 43 % in deoxyglucose uptake is found, whereas the increase in hemidiaphragms is 266%. Interestingly, the basal glucose uptake without insulin is more than twice as high in brain as in hemidiaphragms (Phillips and Coxon, 1976).…”

Section: Discussionmentioning

confidence: 99%

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases

Hoyer

Nitsch

Oesterreich

1991

J Neural Transm Gen Sect

183

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Global cerebral blood flow and the cerebral metabolic rates of oxygen, CO2, glucose and lactate were studied in 11 patients aged 61-78 years who had been clinically diagnosed as suffering from incipient late-onset dementia of the Alzheimer type (DAT), and in 7 patients aged 66-83 years, in whom advanced late-onset DAT had been diagnosed, using the Kety-Schmidt technique. In incipient late-onset DAT, the predominant abnormality was a 45% reduction in cerebral glucose utilization, whereas cerebral blood flow and the cerebral metabolic rate of oxygen were diminished by only 17% and 18%, respectively. A severe imbalance between oxygen utilization and glucose utilization thus became obvious. In contrast, in advanced stages of late-onset DAT, this imbalance between oxygen and glucose utilization rates in the brain became smaller and smaller, and cerebral blood flow diminished markedly; these biological brain parameters finally all settled down at between 55% and 65% of the corresponding control values. The predominant abnormality in brain glucose utilization in incipient late-onset DAT may be associated with an impairment of its control mechanism(s), which are assumed to be either an influence of brain insulin action, or brain insulin receptor function, or both.

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“…The actions of insulin in the central nervous system (CNS) of the intact organism remain uncertain (Rafaelson, 1961a;Phillips and Coxon, 1976;Goodner and Berrie, 1977;Goodner et al, 1980). Some studies have shown failure of insulin to stimulate glucose uptake in brain slices (Goodner and Berrie, 1977) and 2-deoxyglucose transport in rat anterior and posterior medial basal hypothalamus in vivo (Hom et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effect of insulin of glucose and glycogen metabolism and leucine incorporation into protein in cultured mouse astrocytes

Kum

Zhu

et al. 1992

Glia

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Insulin, following binding to its receptor, produces a dose- and time-dependent stimulation of entry of 2-deoxy-D-[U-14C] glucose and glycogen synthesis from D-[U-14C] glucose in cultured mouse astrocytes following differentiation. Maximal stimulation of both glucose entry (217% above basal) and of glycogen synthesis (209% above basal) was observed at an insulin concentration of 1.7 x 10(-8) M. Insulin also stimulates the incorporation of leucine into astrocytic proteins with maximal stimulation (156% above basal) at an insulin concentration of 1.7 x 10(-7) M, but no effect on leucine uptake was observed at an insulin concentration of 1.7 x 10(-6) M. These results, together with a previous demonstration that insulin and certain insulin analogues stimulate pyrimidine nucleoside incorporation into nucleic acid, indicate that insulin has diverse actions on biomacromolecular metabolism in cultured mouse astrocytes.

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Effect of insulin and phenobarbital on uptake of 2‐deoxyglucose by brain slices and hemidiaphragms

Cited by 31 publications

References 16 publications

Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats

Chronic administration of pioglitazone attenuates intracerebroventricular streptozotocin induced-memory impairment in rats

Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases

Effect of insulin of glucose and glycogen metabolism and leucine incorporation into protein in cultured mouse astrocytes

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