Effect of Instrumental Vibration Levels on Dissolution

Embil, Koral; Torosian, George

doi:10.1002/jps.2600681043

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…Embil and Torosian had studied vibration effects on drug release of enteric-coated aspirin tablets in the paddle apparatus [9]. Similar to Beyer and Smith, they observed a more pronounced vibration effect resulting in a decrease in dissolution times at low paddle speeds (50 rpm) which could be overcome by increasing the paddle speed to 200 rpm.…”

Section: Introductionmentioning

confidence: 84%

Impact of Vibration and Agitation Speed on Dissolution of USP Prednisone Tablets RS and Various IR Tablet Formulations

2015

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Abstract. Dissolution testing is an in vitro procedure which is widely used in quality control (QC) of solid oral dosage forms and, given that real biorelevant test conditions are applied, can also be used as a predictive tool for the in vivo performance of such formulations. However, if a dissolution method is intended to be used for such purposes, it has to deliver results that are only determined by the quality of the test product, but not by other variables. In the recent past, more and more questions were arising on how to address the effects of vibration on dissolution test results. The present study was performed to screen for the correlation of prednisone dissolution of USP Prednisone Tablets RS with vibration caused by a commercially available vibration source as well as to investigate how drug release from a range of immediate release formulations containing class 1-4 drugs of the biopharmaceutical classification scheme is affected by vibration when performing dissolution experiments at different agitation rates. Results of the present study show that the dissolution process of oral drug formulations can be affected by vibration. However, it also becomes clear that the degree of which a certain level of vibration impacts dissolution is strongly dependent on several factors such as drug properties, formulation parameters, and the design of the dissolution method. To ensure the establishment of robust and predictive dissolution test methods, the impact of variation should thus be considered in method design and validation.

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Section: Introductionmentioning

confidence: 84%

Impact of Vibration and Agitation Speed on Dissolution of USP Prednisone Tablets RS and Various IR Tablet Formulations

2015

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“…[49] Moreover, vibration and agitation speeds are reported to enhance drug dissolution and delivery. [50][51][52] Seeger et al analyzed and tested the early studies conducted by Beyer and Smith on the dissolution rate of tolbutamide (used for the treatment of non-insulin-dependent diabetes mellitus), [53] and the Embil and Torosian studies on enteric-coated aspirin, [54] and confirmed the strong effects of increasing vibration on the drug dissolution time at a low agitation speed of 50 rpm. [50] Liu et al studied the impact of vibration at 3200, 4800, and 6400 rpm on drug dissolution.…”

Section: Introductionmentioning

confidence: 99%

“…[ 50–52 ] Seeger et al. analyzed and tested the early studies conducted by Beyer and Smith on the dissolution rate of tolbutamide (used for the treatment of non‐insulin‐dependent diabetes mellitus), [ 53 ] and the Embil and Torosian studies on enteric‐coated aspirin, [ 54 ] and confirmed the strong effects of increasing vibration on the drug dissolution time at a low agitation speed of 50 rpm. [ 50 ] Liu et al.…”

Section: Introductionmentioning

confidence: 99%

Influence of Low‐Frequency Vibration and Skin Strain on Insertion Mechanics and Drug Diffusion of PVA/PVP Dissolving Microneedles

Ebrahiminejad,

Malek‐khatabi,

Faraji Rad

2024

Adv Materials Technologies

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Microneedles (MNs) offer a promising solution for increasing the effectiveness of transdermal drug delivery and diagnostics. However, challenges such as large‐scale manufacturing, partial MN penetration, and uncontrolled drug delivery limit the effectiveness of the technology. To overcome these challenges, current research examines the effects of skin strain and vibration on MN insertion and drug delivery. A novel multifeatured impact applicator are developed for improving skin insertion that features a combination of skin stretching, eccentric rotating mass (ERM), and linear resonant actuator (LRA) micro‐vibration capabilities. In addition, a scalable replication method for dissolving microneedle patches (DMNPs) are developed using two‐photon polymerization (TPP) and soft embossing processes. The DMNPs are used to evaluate the diffusion and concentration of a model drug, fluorescein sodium salt (FSS), when applied using ERM and LRA micro‐vibration at different frequencies. Additionally, a new computer simulation method is presented to model the MN insertion into the multilayered hyperelastic skin model, incorporating skin strain and vibrational effects. The results indicate that applying skin strain and vibration decreases the force required for MN insertion and enhances the dissolution and diffusion depth of the drug in the skin, which can enhance the drug permeability and effectiveness of MN devices.

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“…were matched in their performance using a single batch of tablets and modified to reduce unwanted vibrations by the incorporation of a 1000-pF capacitor in the speed control circuit (5).…”

mentioning

confidence: 99%

“…The dissolution vessel was a 900-ml round-bottom resin flask fitted with an appropriate glass cup. Two dissolution apparatus, designated left (L) and right (R), were matched in their performance using a single batch of tablets and modified to reduce unwanted vibrations by the incorporation of a 1000-pF capacitor in the speed control circuit (5).…”

mentioning

confidence: 99%