Effect of Inonotus obliquus extract on body weight gain and blood lipid in obese mice and in vitro pancreas lipase activity

Abstract

This study was to determine changes in the body weight and the serum lipids in obese mice that were fed Inonotus obliquus water extract. Diet‐induced obese male ICR mice (N=18) were divided into three groups: Inonotus obliquus extract of 0mg/day (CONT), 2.25mg/day (IOEX‐1X), and 22.5mg/day (IOEX‐10X). Body weight and % body weight gain were significantly lower during the 8 wk‐feeding period in IOEX‐1X (38.48±1.99g, −5.46±2.92%) and IOEX‐10X (36.06±1.37g, −13.18±3.57%) than those in CONT (40.48±0.94g, 1.32±1.43%). Serum triglyceride was also significantly lower in IOEX‐1X and IOEX‐10X (250.6±12.4mg/dℓ, 246.3±15.8mg/dℓ, respectively) than CONT (284.1±24.2mg/dℓ). Moreover, serum total cholesterol was significantly lower in IOEX‐10X (246.3±15.8mg/dℓ) than CONT (326.5±73.5mg/dℓ). We also measured in vitro pancreas lipase activity, and IOEX was shown to be as low as 71.6% of the CONT. In conclusion, Inonotus obliquus has anti‐obesity function, which may be related to the inhibition in the pancreas lipase activity. (Supported by KRF‐F00014, 2006‐BK21, and Inje FIRST grant)