Effect of Injections of Cortin on Resistance of Suprarenalectomized Rats to Histamine Poisoning.

Abstract

PROCEEDINGS tonella mwis anemia early in life, between the fourth and sixth week. It then becomes a carrier of the Bwtowlka ~u r i s and possesses an acquired immunity to the infection, The infection following splenectomy in the adult carrier rat is indicative of a depression in the acquired resistance to Bartonella mwis. It has been further shown that the acquired resistance to Trypanosoma; Zewisi of normal rats as a result of a previous infection is uninfluenced by subsequent suprarenalectomy. These observations indicate that once a cellular or humoral immunity is established to an infection or an antigenic substance this acquired resistance cannot be broken down by subsequent suprarenalectomy.Bilateral suprarenalectomy, though markedly depressing the natural resistance of the adult albino rat to toxins, poisons and bacterial and protozoan infections, does not affect the acquired resistaim resulting from previous injections of such substances. Acquired and natural resistance are dependent on different physiological processes in the organism and are not merely quantitative variations of the same process as is generally assumed.

The Effect of Bilateral Suprarenalectomy in Adult Albino Rats on the Natural and Acquired Resistance to Bartonella Muris Anemia

“…In the case of suprarenalectomized rats, this resistance can be raised almost to normal by injection of the hormone of the suprarenal cortex (13)(14)(15). In the present communication further data are presented on the effect of bilateral suprarenalectomy in the rat on natural and acquired resistance to BartoneUa muris anemia.…”

“…The resistance is dependent on the activity of cells of the splenic pulp (24). It may be that a hormonal substance is secreted by these cells as suggested by previous work of the authors (24) and by the recent experiments of Lauda and Flaum (25). They joined rats by parabiosis.…”

“…Further, rats fed for long periods of time on a diet deficient in vitamin A acquire severe infections of the accessory nasal sinuses, respiratory tract and urinary tract (30). Such infections resulting in acute inflammatory changes in the spleen, as is commonly observed in Trypanosoma lewisi infection in the rat or in other severe infections (24), may depress the protective function of the cells of the spleen to Bartonetla muris anemia.…”

Relation of the Hypophysis to the Spleen

“…Erythropoiesis seems un-affected. 4 Sections through the lymph nodes show some hyperplasia of the follicles. The Kupffer cells of the liver are unaffected.…”

“…One-fifth of the spleen is adequate to prevent the occurrence of Bartonella muris anemia in carrier stock (4). In the animals included in the experiments reported below the hemoglobin and red cell counts and blood smears were frequently made and no evidence of this infection was observed.…”