Effect of Injectable Contraceptives Depo-Provera and Norethisterone Oenanthate on Pituitary Gonadotropin Response to Luteinizing Hormone-Releasing Hormone

Toppozada, M.; Parmar, Christopher R.; Fotherby, K.

doi:10.1016/s0015-0282(16)43635-6

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Longacting Injectables1

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1979

1990

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Cited by 12 publications

(1 citation statement)

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“…This is clearly demonstrated by the reappearance of cyclic estradiol secretion long before the occurrence of ovulation [47,71]. Unlike the combined pill, DMPA does not suppress the response of the pituitary to gonadotrophin releasing hormone [87]. Norethisterone enanthate also inhibits ovulation in a manner similar to DMPA, but the effect wears off after 60-120 days [28] compared with 3-10 months following DMPA [47].…”

Section: Longacting Injectablesmentioning

confidence: 99%

Mechanism of action of gestagens

Landgren

1990

Intl J Gynecology & Obste

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In the mid-1950s it was shown that ovulation can be inhibited by oral administration of progesterone or of synthetic progestogens such as norethynodrel. The idea that progestogens may interfere with fertility even when administered in doses so small, that they do not invariably inhibit ovulation was launched in the mid-1960s by a group of Mexican investigators. Since then a large number of studies have been conducted on the mechanism of action of gestagens when used as contraceptives. The objective of this communication is to review the information collected so far on this topic.

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