Effect of Inhibitors of Enzymes Involved in Polyamine Biosynthesis Pathway on Pregnancy in Mouse and Hamster

Mehrotra, P.K.; Kitchlu, Surinder; Farheen, Shabana

doi:10.1016/s0010-7824(97)00208-4

Cited by 14 publications

(3 citation statements)

References 11 publications

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“…The authors also confirmed the effectiveness and specificity of ODC antisense in the cortical and striatal tissue by analyzing the ODC catalytic activity and immunoreactive protein levels. It is reasonable to hypothesize that under certain conditions the polyamine system may modulate repair or cell growth in light of its role in embryogenesis and neoplasia (Nishioka et al, 1995; Mehrotra et al, 1998). The authors conclude that a toxic response from the polyamine system after transient ischemia is not mediated by ODC activation.…”

Section: Discussionmentioning

confidence: 99%

Ornithine Decarboxylase Knockdown Exacerbates Transient Focal Cerebral Ischemia-Induced Neuronal Damage in Rat Brain

Rao

Doğan

Bowen

et al. 2001

J Cereb Blood Flow Metab

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Transient cerebral ischemia leads to increased expression of ornithine decarboxylase (ODC). Contradicting studies attributed neuroprotective and neurotoxic roles to ODC after ischemia. Using antisense oligonucleotides (ODNs), the current study evaluated the functional role of ODC in the process of neuronal damage after transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats. Transient MCAO significantly increased the ODC immunoreactive protein levels and catalytic activity in the ipsilateral cortex, which were completely prevented by the infusion of antisense ODN specific for ODC. Transient MCAO in rats infused with ODC antisense ODN increased the infarct volume, motor deficits, and mortality compared with the sense or random ODN-infused controls. Results of the current study support a neuroprotective or recovery role, or both, for ODC after transient focal ischemia.

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Section: Discussionmentioning

confidence: 99%

Ornithine Decarboxylase Knockdown Exacerbates Transient Focal Cerebral Ischemia-Induced Neuronal Damage in Rat Brain

Rao

Doğan

Bowen

et al. 2001

J Cereb Blood Flow Metab

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“…Changes in motility of trophectoderm cells may result from increases in expression of ODC1, the rate-limiting enzyme in polyamine synthesis from Arg, proline and ornithine (Mehrotra et al 1998). Polyamines associate with DNA and nuclear proteins to produce normal chromatinrequired for gene transcription, proliferation of trophectoderm and formation of multinucleated trophectoderm cells that give rise to giant cells in the placentae of mice (Kwon et al 2004a).…”

Section: Polyamines and Trophoblast Motilitymentioning

confidence: 99%

Amino Acids and Conceptus Development During the Peri-Implantation Period of Pregnancy

Bazer

Johnson

2015

Advances in Experimental Medicine and Biology

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The dialogue between the mammalian conceptus (embryo/fetus and associated membranes) involves signaling for pregnancy recognition and maintenance of pregnancy during the critical peri-implantation period of pregnancy when the stage is set for implantation and placentation that precedes fetal development. Uterine epithelial cells secrete and/or transport a wide range of molecules, including nutrients, collectively referred to as histotroph that are transported into the fetal-placental vascular system to support growth and development of the conceptus. The availability of uterine-derived histotroph has long-term consequences for the health and well-being of the fetus and the prevention of Developmental Origins of Health and Disease (DOHAD). Although mechanisms responsible for differential growth and development of the conceptus resulting in DOHAD phenomena remain unclear, epigenetic events involving methylation of DNA are likely mechanisms. Histotroph includes serine and methionine which can contribute to the one carbon pool, and arginine, lysine and histidine residues which may be targets of methylation. It is also clear that supplementing the diet with arginine enhances fetal-placental development in rodents, swine and humans through mechanisms that remain to be elucidated. However, molecules secreted by conceptuses such as interferon tau in ruminants, estrogens and interferons in pigs and chorionic gonadotrophin, along with progesterone, regulate expression of genes for nutrient transporters. Understanding mechanisms whereby select nutrients regulate expression of genes in cell signaling pathways critical to conceptus development, implantation and placentation is required for improving successful establishment and maintenance of pregnancy in mammals.

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Section: Polyamines and Trophoblast Motilitymentioning

confidence: 99%

Cell Signaling During Mammalian Early Embryo Development

Leese¹,

Brison²

2015

Advances in Experimental Medicine and Biology

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Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. The series also provides scientists with up to date information on emerging topics and techniques. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. PrefaceInterest in cell signalling in the early embryo extends over the last 30 years, following extensive research on this topic in somatic cells largely in the context of exogenous growth factors and hormones. Thus, Edirisinghe and Wales (1985), working on preimplantation mouse embryos examined the effect of a variety of agents: glucagon, insulin, adrenaline, cAMP, theophylline and caffeine on glucose metabolism while O'Neill (1985), a pioneer in this field, reported that mouse embryos produced platelet-activating factor (PAF) which stimulated blastocyst rates and cell number. Research then focussed largely on peptide growth factors including their origini.e., whether growth factor ligands and/or receptors were produced by the embryo itself or by the female tract (oviduct and uterus), and their cellular effects, which could be autocrine, paracrine or juxtacrine. A number of excellent reviews of these studies were published: e.g., Schultz and Heyner (1993); Kaye (1997); Kane et al. (1997); Hardy and Spanos (2002).In the last few years interest in embryonic signalling has exploded with (i) the increasing use of ART procedures in animals and humans and the need to improve success rates and safety; (ii) ren...

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Effect of Inhibitors of Enzymes Involved in Polyamine Biosynthesis Pathway on Pregnancy in Mouse and Hamster

Cited by 14 publications

References 11 publications

Ornithine Decarboxylase Knockdown Exacerbates Transient Focal Cerebral Ischemia-Induced Neuronal Damage in Rat Brain

Ornithine Decarboxylase Knockdown Exacerbates Transient Focal Cerebral Ischemia-Induced Neuronal Damage in Rat Brain

Amino Acids and Conceptus Development During the Peri-Implantation Period of Pregnancy

Cell Signaling During Mammalian Early Embryo Development

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