Effect of inhibiting the lactogenic signal at calving on milk production and metabolic and immune perturbations in dairy cows

Vanacker, N.; Ollier, S.; Beaudoin, Frédéric; Blouin, Richard; Lacasse, P.

doi:10.3168/jds.2017-12570

Cited by 18 publications

(17 citation statements)

References 27 publications

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“…Basal and milking-induced PRL were not affected during the DOMP and posttreatment periods by the previous inhibition of PRL concentration by QN. Vanacker et al (2017) reported that PRL inhibition by 4 d of injection of a dopamine agonist into postpartum dairy cows enhanced basal PRL concentration for several weeks after the treatment ended. A short-day photoperiod decreases PRL concentration in bovines (Tucker et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Effect of the concentration of circulating prolactin on dairy cows' responsiveness to domperidone injection

Tong

Thompson

Zhao

et al. 2018

Journal of Dairy Science

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The objective of this study was to determine whether the responsiveness of the mammary gland to prolactin (PRL) is affected by the concentration of the hormone. After 1 pre-experimental week (d -7 to -1), 18 Holstein cows in mid to late lactation were injected intramuscularly twice daily with either 0.5 mg of quinagolide (QN) or 2 mL of water (control) for 2 wk (d 1 to 14; treatment period). After the treatment period, all cows received daily subcutaneous injections of 300 mg of domperidone (DOMP) for 3 wk (d 15 to 35; DOMP period). The cows were monitored for an additional 2 wk as a posttreatment period (d 36 to 49). Blood and milk samples were collected 3 times per week. Additionally, blood samples were collected during the a.m. milking on d -4, 14, and 35. Milk production was not affected by QN during the treatment period but was increased during the DOMP and posttreatment periods in the QN cows. With respect to milk composition, the treatments affected only the protein content, which was greater in the QN cows during the treatment period. Blood PRL concentration declined during QN injections and was lower in the QN cows than in the control cows between d 5 and 14. The basal concentration of PRL was increased by DOMP injections during the DOMP and posttreatment periods but was not affected by previous QN injections. Prolactin concentration in milk was not affected by the QN treatments but was increased by DOMP injections during the DOMP and posttreatment periods. Milking-induced PRL release was decreased by QN on d 14. On d 35, milking did not induce a significant release of PRL above the baseline for both treatments. In conclusion, the results of this experiment support the contention that the mammary gland's responsiveness to PRL is modulated by the previous level of the hormone.

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Section: Discussionmentioning

confidence: 99%

Effect of the concentration of circulating prolactin on dairy cows' responsiveness to domperidone injection

Tong

Thompson

Zhao

et al. 2018

Journal of Dairy Science

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“…The inhibition of PRL has been reported as a promising strategy for reducing metabolic and acute nutritional stress during the postpartum period without compromising the overall productivity of dairy animals. Moreover, an improvement in some aspects of immune system has been associated with the inhibition of PRL during this period [ 70 , 79 ].…”

Section: Lactogenic Hormones During Infection and Immunitymentioning

confidence: 99%

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Alhussien

Dang

2020

Vet World

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Dairy cows are exposed to various stressors during their production cycle that makes them more susceptible to various diseases. Phagocytes (neutrophils and macrophages) are important soldiers of the innate immune system. Neutrophils are the first responders to an inflammatory response and stress and kill pathogens by generating reactive oxygen species and by the release of various antimicrobial peptides, enzymes, neutrophil extracellular trap formation, etc. Macrophages, the other phagocytes, are also the cleanup crew for the innate immune system that removes debris, pathogens, and dead neutrophils later on after an inflammatory response. The neuroendocrine system along with phagocytes exhibits an immunomodulatory potential during stressful conditions. Neuroendocrine system directly affects the activity of phagocytes by communicating bidirectionally through shared receptors and messenger molecules such as hormones, neurotransmitters, or cytokines. Different immune cells may show variable responses to each hormone. Short time exposure to stress can be beneficial, but repeated or extended exposure to stress may be detrimental to the overall health and well-being of an animal. Although some stresses associated with farming practices in dairy cows are unavoidable, better understanding of the interactions occurring between various stress hormones and phagocytic cells can help to reduce stress, improve productivity and animal welfare. This review highlights the role played by various stress hormones in modulating phagocytic cell performance of dairy cattle under inflammatory conditions.

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“…This immune dysfunction is likely driven, at least in part, by incomplete metabolic adaptations to the extreme increase in demand for nutrients to cope with the onset of lactation ( 11 , 12 ). Decreasing initial milk yield and nutrient demand through prolactin blockade increased oxidative burst functionality in neutrophils, although it also decreased lymphocyte proliferation ( 13 ). Supplementation of rumen-protected choline (RPC) to periparturient cows improved their performance and reduced the incidence of diseases ( 14 – 17 ).…”

Section: Introductionmentioning

confidence: 99%

Choline Regulates the Function of Bovine Immune Cells and Alters the mRNA Abundance of Enzymes and Receptors Involved in Its Metabolism in vitro

García

Mamedova

Barton³

et al. 2018

Front. Immunol.

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Dietary choline can impact systemic immunity, but it remains unclear whether this is primarily via direct impacts on immune cells or secondary effects of altered metabolic function. To determine whether increased choline concentrations (3.2, 8.2, 13.2 μM) in cell culture alter the function of bovine innate and adaptive immune cells, we isolated cells from dairy cows in early and mid-lactation as models of immuno-compromised and competent cells, respectively. Phagocytic and killing capacity of isolated neutrophils were linearly diminished with increasing doses of choline. In contrast, lymphocyte proliferation was linearly enhanced with increasing doses of choline. Furthermore, increasing doses of choline increased the mRNA abundance of genes involved in the synthesis of choline products (betaine, phosphatidylcholine, and acetylcholine) as well as muscarinic and nicotinic acetylcholine receptors in a quadratic and linear fashion for neutrophils and monocytes, respectively. Phagocytic and killing capacity of neutrophils and proliferation of lymphocytes were not affected by stage of lactation or its interaction with choline or LPS. In neutrophils from early lactation cows, choline linearly increased the mRNA abundance of muscarinic and nicotinic cholinergic receptors, whereas choline-supplemented monocytes from mid-lactation cows linearly increased the mRNA abundance of several genes coding for choline metabolism enzymes. These data demonstrate that choline regulates the inflammatory response of immune cells and suggest that the mechanism may involve one or more of its metabolic products.

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Effect of inhibiting the lactogenic signal at calving on milk production and metabolic and immune perturbations in dairy cows

Cited by 18 publications

References 27 publications

Effect of the concentration of circulating prolactin on dairy cows' responsiveness to domperidone injection

Effect of the concentration of circulating prolactin on dairy cows' responsiveness to domperidone injection

Interaction between stress hormones and phagocytic cells and its effect on the health status of dairy cows: A review

Choline Regulates the Function of Bovine Immune Cells and Alters the mRNA Abundance of Enzymes and Receptors Involved in Its Metabolism in vitro

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