Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes

Hoshino, Yoshifumi; Koya, Toshiyuki; Kagamu, Hiroshi; Tsukioka, Keisuke; Toyama, Makoto; Sakagami, Takuro; Hasegawa, Takashi; Narita, Ichiei; Arakawa, Masaaki; Suzuki, Eiichi

doi:10.1016/j.alit.2014.10.004

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…However, 15% of athletes only showed a minimal response to ICS. 139 Heterogeneity of asthma phenotypes in the athlete population 132,140-142 probably explains why not all asthmatic athletes respond to ICS. Indeed, many athletes have little or no evidence of eosinophilic airway inflammation, 76,143,144 and therefore may not benefit as much from ICS as other individuals with eosinophilic asthma.…”

Section: Prevention Of Exercise-induced Bronchoconstriction In Athletesmentioning

confidence: 99%

Exercise and Asthma

Côté

Turmel

Boulet

2018

Semin Respir Crit Care Med

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Transient airway narrowing can occur during or following exercise, a phenomenon called exercise-induced bronchoconstriction (EIB). The main mechanism of EIB is considered to be airway dehydration, resulting from increased ventilation during exercise. In asthma, such water loss causes an increase in airway fluid osmolarity, inducing airway smooth muscle contraction following the release of mediators from airway inflammatory cells. Asthmatics frequently experience EIB, but it may also be observed in others not reporting asthma symptoms, particularly elite endurance athletes. Individuals with asthma often refrain from performing physical exercise because they fear troublesome respiratory symptoms. However, in addition to its well-known cardiovascular and metabolic benefits, physical training has been shown to be beneficial for asthmatic adults and children in improving asthma control and asthma-related quality of life. Exercise training also reduces the risk of asthma exacerbations, improves exercise capacity, and decreases frequency and severity of EIB. To minimize the risk of EIB, asthma must be well controlled, and specific pharmacological and nonpharmacological preventative measures can be taken. Counterintuitively, in high-level athletes, the development of asthma, airway hyperresponsiveness, and EIB can be promoted by intense training over many years following exposure to environmental conditions, such as cold air, pollutants, and allergens. As for nonathletes, athletes must have optimal asthma control and apply preventative measures against EIB, taking into account antidoping regulations for asthma medications. A better understanding of the impact of exercise on asthma should improve the overall care of asthmatic patients.

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Section: Prevention Of Exercise-induced Bronchoconstriction In Athletesmentioning

confidence: 99%

Exercise and Asthma

Côté

Turmel

Boulet

2018

Semin Respir Crit Care Med

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“…Doses of inhaled glucocorticosteroids are determined by the degree of symptoms severity. Daily doses of in- [45].…”

Section: Medical History Datamentioning

confidence: 99%

Asthma and exercise-induced respiratory disorders in athletes. The position paper of the Polish Society of Allergology and Polish Society of Sports Medicine

Gawlik¹,

Kurowski²,

Kowalski³

et al. 2019

pja

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Exercise-induced respiratory symptoms describe acute airway narrowing that occurs as a result of exercise. It includes exercise-induced bronchoconstriction (EIB) and exercise-induced asthma (EIA) issues. To provide clinicians with practical guidelines, a multidisciplinary panel of stakeholders was convened to review the pathogenesis of EIB/EIA and to develop evidence-based guidelines for the diagnosis and treatment. Recommendations for the diagnosis and treatment of EIB were developed. High-intensity exercise in polluted environment (cold air, humidity, contamination, allergens) may increase the risk of EIB and asthma symptoms in athletes. Diagnostic procedures should include history taking, physical examination, atopy assessment and functional tests of the respiratory system. A strong recommendation was made for regular use of inhaled glucocorticosteroids and avoidance of short-acting β 2-agonists as the only treatment. The treatment of asthma in athletes should always take into account current anti-doping regulations. This position paper reflects the currently available evidence.

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“…Occasionally, for various reasons, inhaled glucocorticosteroids are less effective in asthma control in competitive athletes. Hoshino et al reported ineffectiveness of therapy with inhaled glucocorticosteroids in 16.3% of 80 asthmatic athletes [45].…”

Section: Treatmentmentioning

confidence: 99%

Asthma and exercise-induced respiratory disorders in athletes. The position paper of the Polish Society of Allergology and Polish Society of Sports Medicine

Gawlik

Kurowski

Ziętkowski

et al. 2019

pdia

View full text Add to dashboard Cite

Exercise-induced respiratory symptoms describe acute airway narrowing that occurs as a result of exercise. It includes exercise-induced bronchoconstriction (EIB) and exercise-induced asthma (EIA) issues. To provide clinicians with practical guidelines, a multidisciplinary panel of stakeholders was convened to review the pathogenesis of EIB/EIA and to develop evidence-based guidelines for the diagnosis and treatment. Recommendations for the diagnosis and treatment of EIB were developed. High-intensity exercise in polluted environment (cold air, humidity, contamination, allergens) may increase the risk of EIB and asthma symptoms in athletes. Diagnostic procedures should include history taking, physical examination, atopy assessment and functional tests of the respiratory system. A strong recommendation was made for regular use of inhaled glucocorticosteroids and avoidance of short-acting β2-agonists as the only treatment. The treatment of asthma in athletes should always take into account current anti-doping regulations. This position paper reflects the currently available evidence.

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Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes

Abstract: These data suggest that ICS is effective for asthma in most athletes. However, certain asthmatic athletes are less responsive to ICS than expected. The pathogenesis in these subjects may differ from that of conventional asthma characterized by chronic allergic airway inflammation.

Cited by 15 publications

References 28 publications

Exercise and Asthma

Exercise and Asthma

Asthma and exercise-induced respiratory disorders in athletes. The position paper of the Polish Society of Allergology and Polish Society of Sports Medicine

Asthma and exercise-induced respiratory disorders in athletes. The position paper of the Polish Society of Allergology and Polish Society of Sports Medicine

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