Effect of ingredients from Chinese herbs on enterovirus D68 production

Meng, Xiang-Ling; Yu, Xiaoyan; Liu, Chunyu; Wang, Ying; Song, Fang; Chen, Huan; Huo, Wenbo; Zhang, Shuxia; Li, Zhaolong; Zhang, Jun; Zhang, Wenyan; Yu, Jinghua

doi:10.1002/ptr.6214

Cited by 13 publications

(5 citation statements)

References 51 publications

(82 reference statements)

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“…Erianin is a small molecular dibenzyl compound extracted from Dendrobium . Previous studies have demonstrated that Erianin exerts a variety of pharmacological effects, including antiviral [ 32 ], antiaging, antidiabetic, and anti-inflammatory activities [ 33 ] and inhibits angiogenesis [ 34 , 35 ]. Especially in the treatment of tumors, it has significant antitumor activity, including liver cancer [ 10 , 36 ], lung cancer [ 13 , 18 , 34 ], nasopharyngeal cancer [ 37 ], cervical cancer [ 38 ], bladder cancer [ 9 ], osteosarcoma [ 12 ], etc., However, the molecular mechanism and cellular targets through which Erianin acts against TNBC are poorly systematically defined, which is important for understanding its potential anticancer mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Erianin anti-triple negative breast cancer based on transcriptomics methods and network pharmacology

Li,

Zhao,

et al. 2024

Aging

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Triple negative breast cancer (TNBC) is a highly aggressive illness that lacks effective targeted treatments. Although Erianin has shown potential antitumor properties, its precise mechanism of action and target in TNBC remain unclear, hampering the development of drugs. The present study investigated the underlying mechanism of action of Erianin in treating TNBC by using transcriptomics and network pharmacology approaches. We evaluated Erianin's bioactivity in TNBC cell lines and xenograft tumor models. The results showed that Erianin significantly inhibited TNBC cell proliferation and impeded tumor growth. A subsequent analysis of transcriptomic and network pharmacological data identified 51 mutual targets. Analysis of proteinprotein interactions identified eight hub targets. Furthermore, molecular docking indicated that the PPARA binding energy was the lowest for Erianin among the hub targets, followed by ROCK2, PDGFRB, CCND1, MUC1, and CDK1. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analysis showed that the common targets were associated with multiple cancer-related signaling pathways, including focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway, microRNAs in cancer, and human papillomavirus infection. The results of the Western blot and immunohistochemistry experiment further showed that Erianin could suppress PI3K/Akt signaling pathway activation. After co-incubation with SC79, the cell inhibition rate of Erianin was decreased, which further confirmed that Erianin inhibits TNBC progression via the PI3K-AKT signaling pathway. In conclusion, our results indicated that Erianin has the potential to inhibit the proliferation of TNBC by downregulating the PI3K/AKT signaling pathway by transcriptomics and network pharmacology. Therefore, Erianin appears to be a promising compound for the effective treatment of TNBC.

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Section: Discussionmentioning

confidence: 99%

Mechanism of Erianin anti-triple negative breast cancer based on transcriptomics methods and network pharmacology

Li,

Zhao,

et al. 2024

Aging

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“…Out of the nine unique metabolites retrieved from S. polydactyla, two of them, namely, erianin and methotrexate, have been reported for their biological properties, such as antitumor, antiviral, anti-inflammatory, and immunosuppressant properties [31][32][33][34]. Additionally, ketoconazole, reported in the C. simplex extract only, was reported to have antifungal, antiviral, anticancer, and anti-inflammatory properties [35][36][37][38].…”

Section: Metabolites From Mauritian Soft Coralsmentioning

confidence: 99%

Metabolic Profiling, Antiviral Activity and the Microbiome of Some Mauritian Soft Corals

Jahajeeah,

Ranghoo-Sanmukhiya,

Schäfer

2023

Marine Drugs

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Soft corals, recognized as sessile marine invertebrates, rely mainly on chemical, rather than physical defense, by secreting intricate secondary metabolites with plausible pharmaceutical implication. Their ecological niche encompasses a diverse community of symbiotic microorganisms which potentially contribute to the biosynthesis of these bioactive metabolites. The emergence of new viruses and heightened viral resistance underscores the urgency to explore novel pharmacological reservoirs. Thus, marine organisms, notably soft corals and their symbionts, have drawn substantial attention. In this study, the chemical composition of four Mauritian soft corals: Sinularia polydactya, Cespitularia simplex, Lobophytum patulum, and Lobophytum crassum was investigated using LC–MS techniques. Concurrently, Illumina 16S metagenomic sequencing was used to identify the associated bacterial communities in the named soft corals. The presence of unique biologically important compounds and vast microbial communities found therein was further followed up to assess their antiviral effects against SARS-CoV-2 and HPV pseudovirus infection. Strikingly, among the studied soft corals, L. patulum displayed an expansive repertoire of unique metabolites alongside a heightened bacterial consort. Moreover, L. patulum extracts exerted some promising antiviral activity against SARS-CoV-2 and HPV pseudovirus infection, and our findings suggest that L. patulum may have the potential to serve as a therapeutic agent in the prevention of infectious diseases, thereby warranting further investigation.

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“…Overview Thisisbutasampleofhowmachinelearningtools(andothers)canbeusedtohelplevelthedemand profileandreducethelevelofuncertaintyforhospitalplanners. ThemanagementofmedicalassetssuchasIVmachinesandventilatorshaslongbeenanarea ofconcernduetothehighcostoftheseitemsandtheirimportanceinthehealingofpatients.The elevenarticlesinthissub-themelookspecificallyattheuseofBigDatatechnologiestoimprove theavailablilityandutilizationoftheseimportantassets.SomestudiesprovideapproachestoIoTbasedsystemsthathelptolocateandmanagetheusageofwheelchairs (Kurita,Matsuo&Barolli, 2019),incubators (Kovačevićetal,2019),andrehabilitationequipment (Meng,Zhang&Yu,2018). Othersapplythesetoolstotheneedforpredictingmaintenance (Shamayleh,Awad&Farhat,2020) ormonitoringperformance (Gurbeta,Badnjević&Kurta,2020)ofmedicalequipment.…”

Section: Sub-themementioning

confidence: 99%

Big Data Applications in Healthcare Administration

Kasten

2020

International Journal of Big Data and Analytics in Healthcare

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The healthcare industry has a growing record of using big data-related technologies such as data analytics, internet of things, and machine learning, especially in the clinical areas. However, healthcare institutions must also perform all of the administrative processes just as any other organization. Thus, like many other industries, healthcare has begun to apply these same technologies to improve their understanding of these internal operations and use them to make better decisions and run a more effective operation. This study takes a structured literature review approach to describe the current state of this literature and identify the major themes and priorities of both the research community and the healthcare industry as a whole. The contribution made by this study is to provide a comprehensive analysis of the state of the literature to use as a foundation for the future research opportunities noted in the paper.

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Effect of ingredients from Chinese herbs on enterovirus D68 production

Cited by 13 publications

References 51 publications

Mechanism of Erianin anti-triple negative breast cancer based on transcriptomics methods and network pharmacology

Mechanism of Erianin anti-triple negative breast cancer based on transcriptomics methods and network pharmacology

Metabolic Profiling, Antiviral Activity and the Microbiome of Some Mauritian Soft Corals

Big Data Applications in Healthcare Administration

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