“…4 . 5 ) On the other hand, sucrosemediated changes in jejunal sucrase activity in these rats were initiated at the level of the crypt cell and were expressed after a latent period of 18 to 20 hr, during which these cells matured and migrated toward the villus tip.4,6-S) Cezard et al,9,!O) thereafter, reported that the maximal increase in sucrase activity caused by sucrose feeding in rats given a carbohydratefree diet occurred by 12 hr after giving the sucrose diet, and separation of villus and crypt cells 12 hr after giving the diet revealed a parallel increase of sucrase activity along the villus-crypt axis. They proposed that the sucrose-mediated increase in sucrase actIvIty, rather than acting preferentially on the crypt, occurred over the entire villus-crypt unit.…”