Effect of Infrared Radiation on the Healing of Diabetic Foot Ulcer

Hakim, Ashrafalsadat; Moghadam, Ali Sadeghi; Shariati, Abdalali; Karimi, Hamid; Haghighizadeh, Mohammad Hosein

doi:10.5812/ijem.32444

Cited by 12 publications

(14 citation statements)

References 16 publications

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“…However, the gel at the concentration of 15% had the greatest effect on the discharge reduction of diabetic foot ulcers. In Hakim et al (20) and Nasiri et al ( 6), a significant difference was observed between the two groups in terms of tissues surrounding the wound in weeks 2, 3, and 4 of treatment, which is in line with the results of the present study.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the effect of a gel made with amniotic fluid formulation on the healing of diabetic foot ulcers: A triple-blind clinical trial

Niami

Molavynejad

Hemmati

et al. 2022

Front. Public Health

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AimThe aim of this study was to evaluate the effect of a gel made with amniotic fluid (AF) formulation on wound healing in diabetic foot ulcers.MethodsThis clinical trial was performed on 92 type 2 diabetic patients referring to the Diabetes Clinic of Golestan Hospital of Ahvaz, southwest of Iran in 2019–2020. Patients were randomly divided into three groups of intervention and one placebo group. The wounds of the three intervention groups were dressed with gauze impregnated with an AF formulation gel while wounds of the control group were dressed with plain gauze without any topical agent. Chi-square tests and generalized estimating equations (GEE) with a significance level of 0.05 were used to analyze the data.ResultsAt the end of the eighth week of intervention, there was a statistically significant difference among the four groups in terms of wound grade, wound color, condition of the tissues surrounding the wound, the overall condition of the wound, and the duration of wound healing (P < 0.05).ConclusionsBased on our experience with the patients in the present study, we believe that AF represents a useful and safe option for the treatment of chronic diabetic foot ulcers.Clinical trial registrationhttps://en.irct.ir/trial/51551, Identifier: IRCT20201010048985N1.

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Section: Discussionsupporting

confidence: 92%

Evaluation of the effect of a gel made with amniotic fluid formulation on the healing of diabetic foot ulcers: A triple-blind clinical trial

Niami

Molavynejad

Hemmati

et al. 2022

Front. Public Health

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“…The previous reviews found nine studies of physical therapies, including shockwaves, ultrasound, laser therapy, magnetism, and electrical current. The current review found a number of new controlled studies; one study of ultrasound two of extracorporeal shockwaves, three of low level Laser therapy, one of advanced class IV laser emitting four wavelengths, two using photodynamic therapy (PDT), one using infrared radiation, and one on pneumatic compression . All were of high risk of bias or showed no evidence of benefit.…”

Section: Recommendationsmentioning

confidence: 99%

Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update)

Rayman

Vas

Dhatariya

et al. 2020

Diabetes Metabolism Res

160

183

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The International Working Group on the Diabetic Foot (IWGDF) has published evidence‐based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of the literature centred on the following: the Population (P), Intervention (I), Comparator (C) and Outcomes (O) framework; the use of the SIGN guideline/Cochrane review system; and the 21 point scoring system advocated by IWGDF/EWMA. This has resulted in 13 recommendations. The recommendation on sharp debridement and the selection of dressings remain unchanged from the last recommendations published in 2016. The recommendation to consider negative pressure wound therapy in post‐surgical wounds and the judicious use of hyperbaric oxygen therapy in certain non‐healing ischaemic ulcers also remains unchanged. Recommendations against the use of growth factors, autologous platelet gels, bioengineered skin products, ozone, topical carbon dioxide, nitric oxide or interventions reporting improvement of ulcer healing through an alteration of the physical environment or through other systemic medical or nutritional means also remain. New recommendations include consideration of the use of sucrose‐octasulfate impregnated dressings in difficult to heal neuro‐ischaemic ulcers and consideration of the use of autologous combined leucocyte, platelet and fibrin patch in ulcers that are difficult to heal, in both cases when used in addition to best standard of care. A further new recommendation is the consideration of topical placental derived products when used in addition to best standard of care.

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“…The interim analysis of an otherwise unpublished study of noncontact normothermic therapy (ulcer warming by infrared radiation) reported greater percentage ulcer area reduction than saline‐moistened gauze control, although this result must be treated with caution given the high risk of bias. Two other studies were identified: one using infrared radiation via a tungsten generator and another using thrice weekly pulsed radiofrequency treatment, both of which reported apparent benefit, but the robustness of these results could not been ascertained as the study reports contained a number of methodological and statistical errors and were, therefore, at a high risk of bias.…”

Section: Physical Therapiesmentioning

confidence: 99%

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

Vas

Rayman

Dhatariya

et al. 2020

Diabetes Metabolism Res

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The management of diabetic foot ulcers (DFU) remains a challenge, and there is continuing uncertainty concerning optimal approaches to wound healing. The International Working Group of the Diabetic Foot (IWGDF) working group on wound healing has previously published systematic reviews of the evidence in 2008, 2012 and 2016 to inform protocols for routine care and to highlight areas which should be considered for further study. The working group has now updated this review by considering papers on the interventions to improve the healing of DFU's published between June 2014 and August 2018. Methodological quality of selected studies was independently assessed by a minimum of two reviewers using the recently published 21‐point questionnaire as recommended by IWGDF/European Wound Management Association, as well as the previously incorporated Scottish Intercollegiate Guidelines Network criteria. Of the 2275 papers identified, 97 were finally selected for grading following full text review. Overall, there has been an improvement in study design and a significant rise in the number of published studies. While previous systematic reviews did not find any evidence to justify the use of newer therapies, except for negative pressure wound therapy in post‐surgical wounds, in this review we found additional evidence to support some interventions including a sucrose‐octasulfate dressing, the combined leucocyte, fibrin and platelet patch as well as topical application of some placental membrane products, all when used in addition to usual best care. Nonetheless, the assessment and comparison of published trials remains difficult with marked clinical heterogeneity between studies: in patient selection, study duration, standard of usual care provision and the timing and description of the clinical endpoints.

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Effect of Infrared Radiation on the Healing of Diabetic Foot Ulcer

Cited by 12 publications

References 16 publications

Evaluation of the effect of a gel made with amniotic fluid formulation on the healing of diabetic foot ulcers: A triple-blind clinical trial

Evaluation of the effect of a gel made with amniotic fluid formulation on the healing of diabetic foot ulcers: A triple-blind clinical trial

Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update)

Effectiveness of interventions to enhance healing of chronic foot ulcers in diabetes: a systematic review

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