Effect of Indomethacin on the Adrenal Response to Frusemide in the Rat

Spät, András; Józan, Sára; K, Gaál; Mózes, T

doi:10.1677/joe.0.0730401

Cited by 5 publications

(1 citation statement)

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“…4c). DISCUSSION Observations in man (Tan & Mulrow, 1977 (Spät, Józan, Gaál & Mózes, 1977;Spät, Tarjan & Tóth, 1979) suggested that prostaglandins were involved in the control of aldosterone synthesis. This assumption was in agreement with a recent report (Shima, Kawashima, Hirai & Asakura, 1980) However, Matsuoka et al (1980) could not demonstrate the enhancement of aldosterone production by isolated rat glomerulosa cells in the presence of PGE2 or the prostaglandin precursor, arachidonic acid (3 10"8 to 3 10~4mol/1).…”

Section: Resultsmentioning

confidence: 98%

Role of Prostaglandins in the Control of the Function of Adrenal Glomerulosa Cells

Enyedi

Spät

Antoni

1981

Journal of Endocrinology

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The role of prostaglandins in the control of aldosterone production was studied in isolated rat glomerulosa cells. Exogenous prostaglandin E2 in concentrations above 10(-9) mol/l increased the production rate of aldosterone; this effect was attenuated by the competitive antagonist, 7-oxa-13-prostynoic acid. Prostaglandin F2 alpha (10(-9)--10(-5) mol/l) failed to influence the production rate of aldosterone. The aldosterone-stimulating effect of the prostaglandin precursor, arachidonic acid (5 x 10(-4) mol/l), could not be blocked by inhibitors of prostaglandin synthesis. Basal production rate of aldosterone was not significantly influenced by non-steroidal anti-inflammatory drugs. Glomerulosa cells were stimulated by angiotensin II; this effect was not potentiated by arachidonic acid and was reduced only slightly by indomethacin. The cells were also stimulated by corticotrophin and potassium ions. The effect of these substances was not potentiated by arachidonic acid and was not inhibited by non-steroidal anti-inflammatory drugs. These results do not confirm the presumption that intra-adrenal prostaglandins play an essential role in the control of aldosterone secretion. Some effects of arachidonic acid and its antagonist, eicosatetraynoic acid, on aldosterone production are considered to be independent of changes in prostaglandin synthesis.

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Section: Resultsmentioning

confidence: 98%

Role of Prostaglandins in the Control of the Function of Adrenal Glomerulosa Cells

Enyedi

Spät

Antoni

1981

Journal of Endocrinology

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The relationship between tissue preparation and function; methods for the study of control of aldosterone secretion: A review

Vinson

Hinson

Raven

1985

Cell Biochemistry & Function

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The study of the control of aldosterone synthesis and secretion by the rat adrenal gland has over the past thirty years involved the application of many different in vivo and in vitro techniques. In this review the relationship between the data that each of these methods has produced is compared. There are striking differences in overall steroid production rates, and in the qualitative nature of the steroid profile which the various methods produce. In particular, aldosterone is secreted at higher rates in vivo, and when whole tissue preparations are used in vitro, than in incubations of isolated glomerulosa cells. In addition, while corticosterone is a major product of glomerulosa tissue in vitro, the available evidence suggests that it is not a major glomerulosa product in vivo.

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Drug interactions

Orme¹

1986

Therapeutics in Rheumatology

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Effect of Indomethacin on the Adrenal Response to Frusemide in the Rat

Cited by 5 publications

References 5 publications

Role of Prostaglandins in the Control of the Function of Adrenal Glomerulosa Cells

Role of Prostaglandins in the Control of the Function of Adrenal Glomerulosa Cells

The relationship between tissue preparation and function; methods for the study of control of aldosterone secretion: A review

Drug interactions

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