Effect of indomethacin on brain water content, cerebrospinal fluid white blood cell response and prostaglandin E2 levels in cerebrospinal fluid in experimental pneumococcal meningitis in rabbits

Tureen, Jay H.; STELLA, FELICIA B.; CLYMAN, RONALD I.; MAURAY, F.; Sande, Merle A.

doi:10.1097/00006454-198712000-00029

Cited by 26 publications

(4 citation statements)

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“…This could be one explanation for the lower PMN numbers found in cerebrospinal fluid in some clinical studies on dexamethasone therapy (6) and in experimental animals (17). The role of LTB4 is further emphasized by the observation that non-steroidal anti-inflammatory medications, like indomethacin which affect prostaglandin formation only but do not affect leukotriene formation, have resulted in a delayed reduction of elevated PMN numbers in cerebrospinal fluid (18,19).…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid concentrations of leukotriene B₄ in bacterial meningitis

1996

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We investigated whether leukotriene B4 (LTB4), a granulocyte inflammatory mediator, is detectable in cerebrospinal fluid using a high performance liquid chromatographic method. In non-pleocytotic cerebrospinal fluid (n = 5) and in cerebrospinal fluid from children with aseptic meningitis (n = 8), LTB4 concentrations were below the detection limit (< 0.2 ng ml-1). In the range 0-20 ng ml-1, the recovery rate of LTB4 that had been added to non-pleocytotic cerebrospinal fluid was > 90%. In cerebrospinal fluid with a polymorphonuclear leucocyte (PMN) count higher than 1,000/ml, LTB4 was detectable in six out of seven specimens with a concentration of 0.35-3.3 ng ml-1. LTB4 concentration was significantly correlated with PMN number. These results, together with observations in animal models, are discussed with regard to a pathophysiological role of LTB4 in bacterial meningitis.

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid concentrations of leukotriene B₄ in bacterial meningitis

1996

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“…16 The local hyopxia and ischemia are associated with elevations of arachidonic acid metabolites. 17 Steroids seem to have some role in inhibiting the production of these arachidonic acid metabolites by pathways that involve interleukin 1 and cachectin.…”

Section: Methodsmentioning

confidence: 99%

Preventing Labyrinthitis Ossificans

Hartnick¹,

Kim²,

Chute³

et al. 2001

Arch Otolaryngol Head Neck Surg

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“…A study in rabbits with experimental meningitis demonstrated a dramatically decreased mortality by the use of a combination of ampicillin plus oxindanac in comparison with treatment with ampicillin alone or ampicillin plus dexamethasone or indomethacin. Trials of selected nonsteroidal anti-inflammatory agents hold much promise [49,50,119,121,122].…”

Section: Inhibition Of Prostaglandinsmentioning

confidence: 99%

Bacterial meningitis: Mechanisms of disease and therapy

1995

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Bacterial meningitis continues to be a serious infectious disease with a high morbidity and mortality in young children. Early recognition and initiation of adequate treatment are the major determinants for a good outcome. Recent advances in our understanding of the host inflammatory response by cytokines may result in the use of new therapeutic strategies. Such modulation of the inflammatory response may reduce the incidence of sequelae and death. The use of steroids as adjunctive therapy in children with bacterial meningitis probably has beneficial effects although the available data are still controversial. Additionally, studies in experimental meningitis models indicate that non-steroidal anti-inflammatory drugs and monoclonal antibodies against bacterial products, cytokines and CD18 on leucocytes reduce the extent of the meningeal inflammation. Human studies to evaluate the efficacy of these immune modulators are expected to start soon. However, prevention of bacterial meningitis by conjugate vaccines against Streptococcus pneumoniae and Neisseria meningitidis will be the most promising development in the next decade.

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Effect of indomethacin on brain water content, cerebrospinal fluid white blood cell response and prostaglandin E2 levels in cerebrospinal fluid in experimental pneumococcal meningitis in rabbits

Cited by 26 publications

References 0 publications

Cerebrospinal fluid concentrations of leukotriene B₄ in bacterial meningitis

Cerebrospinal fluid concentrations of leukotriene B₄ in bacterial meningitis

Preventing Labyrinthitis Ossificans

Bacterial meningitis: Mechanisms of disease and therapy

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Effect of indomethacin on brain water content, cerebrospinal fluid white blood cell response and prostaglandin E2 levels in cerebrospinal fluid in experimental pneumococcal meningitis in rabbits

Cited by 26 publications

References 0 publications

Cerebrospinal fluid concentrations of leukotriene B4 in bacterial meningitis

Cerebrospinal fluid concentrations of leukotriene B4 in bacterial meningitis

Preventing Labyrinthitis Ossificans

Bacterial meningitis: Mechanisms of disease and therapy

Contact Info

Product

Resources

About

Cerebrospinal fluid concentrations of leukotriene B₄ in bacterial meningitis

Cerebrospinal fluid concentrations of leukotriene B₄ in bacterial meningitis