Effect of Indigestible Polysaccharides on Accumulation of Pentachlorobenzene in Rats

Tsuchihashi, Fumie; Ikegami, Sachie; Umegaki, Keizo; Ichikawa, Tomio

doi:10.3358/shokueishi.33.241

Cited by 2 publications

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“…As shown in Table 1, the amounts of epididymal and perirenal fat tissue in the alginate and fish oil groups were lower than those in the control group. The results are consistent with our previous reports that feeding dietary fiber and fish oil to rats reduces the total content of fat in the body (3)(4)(5)(6)(7). It is widely recognized that fat tissue has an important role in the storage of drugs or xenobiotics in the body.…”

Section: Resultssupporting

confidence: 92%

“…It easily crosses the gastrointestinal wall and rapidly disappears from the blood , being ex haled unchanged or accumulated in tissues via the blood stream and metabolization (17,22,23). TCE is more rapidly metabolized than PECB or HCB, which were used in our previous studies (3)(4)(5)(6)(7). In those studies, we found that PECB residues in the body were much lower in amount in rats fed viscous indigestible polysaccharides (3,4) and fish oil (5,6).…”

Section: Resultsmentioning

confidence: 88%

“…In previous studies, we have observed that the metabolism and excretion of lipophilic and relatively metabolizable pentachlorobenzene (PECB) were markedly increased in rats when they were fed a restricted diet (1,2), viscous dietary fibers (3,4) or fish oil (5,6). We have also reported that the feeding of fish oil (7) or guar gum (8) to rats enhanced the metabolism and excretion of hexachlorobenzene (HCB), * To whom correspondence should be addressed .…”

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confidence: 99%

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Effects of Sodium Alginate and Fish Oil to Reduce Trichloroethylene Accumulation i Rats.

Ikegami

Umegaki²

1999

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThis study was conducted to examine the effect of dietary sodium alginate and fish oil on bodily accumulated trichloroethylene (TCE), which has been widely used as a halogenated solvent and is me tabolized at a high rate. Each of three groups of rats was fed on either of diets containing cellulose-soybean oil (control), Na-alginate-soybean oil or cellulose-fish oil for 3 wk, and thereafter given a single oral dose of TCE (100mg (0.76mmol)/rat). TCE levels in the blood were moni tored for 10h after the administration of TCE. The peak concentrations of TCE in the blood tended to be higher in the alginate and fish oil groups as compared with those in the cellulose-soybean oil group, but not to a significant extent. TCE concentrations in the liver, kidney, brain and the three fat tissues (epididymal, perirenal and subcutaneous) were significantly lower in the alginate and fish oil groups than in the cellu lose-soybean oil group. Fat tissue weights were also lower in the alginate group and fish oil group. The hepatic drug metabolizing enzymes could not account for the remarkable decreases of residual TCE contents in the alginate and fish oil groups. These findings indicate that the metabolism and excretion of TCE might be accelerated in animals with reduced fat tissue mass. Key Words trichloroethylene, Na-alginate, fish oil, accumulation, fat tissueIn previous studies, we have observed that the metabolism and excretion of lipophilic and relatively metabolizable pentachlorobenzene (PECB) were markedly increased in rats when they were fed a restricted diet (1, 2), viscous dietary fibers (3, 4) or fish oil (5, 6). We have also reported that the feeding of fish oil (7) or guar gum (8) to rats enhanced the metabolism and excretion of hexachlorobenzene (HCB),

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 88%

mentioning

confidence: 99%

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Effects of Sodium Alginate and Fish Oil to Reduce Trichloroethylene Accumulation i Rats.

Ikegami

Umegaki²

1999

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…It has been shown that fat tissue mass is involved in the distribution, metabolism, and excretion of lipophilic compounds such as pentachlorobenzene (PECB), which is metabolized at a relatively slow rate, and hexachlorobenzene (HCB), which is metabolized at a much slower rate than PECB. We have also observed that the metabolism and excretion of PECB and HCB were markedly increased in rats when they were fed a restricted diet ( , ), viscous dietary fibers ( − ), or fish oil ( − ). This enhanced metabolism and excretion of such lipophilic compounds was not due to the enhancement of the activity of hepatic drug-metabolizing enzymes per se, but due to the small mass of fat tissue that resulted from those treatments ( 8, 11, 12 ).…”

Section: Introductionmentioning

confidence: 91%

Guar Gum Reduces Trichloroethylene Accumulation in the Body by Reducing TCE Absorption and Fat Tissue Mass

Nakashima

Ikegami

2001

J. Agric. Food Chem.

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Two studies were conducted regarding the effects of guar gum on accumulation and metabolism of trichloroethylene (TCE). In study 1, 6- and 14-weeks-old rats were given a single oral dose of 100 mg of trichloroethylene (TCE). Ten hours after administration of TCE, a marked positive correlation was noted between relative fat tissue weights and TCE distribution in fat tissues. Therefore, a small mass of fat tissue apparently limited TCE accumulation. In study 2, each of four groups of rats was fed one of four diets: cellulose-soybean oil, cellulose-docosahexaenoic acid (DHA), guar gum-soybean oil, or guar gum-DHA for 3 weeks and then all were given TCE as in study 1. The rate of decrease of TCE distributed in fat tissues of groups fed guar gum compared with corresponding groups fed cellulose was greater than the rate of decrease in relative weight of these tissues. TCE absorption by groups fed guar gum decreased 12% compared with TCE absorption of corresponding groups fed cellulose. Therefore, guar gum decreased TCE accumulation in the body by reducing TCE absorption and fat tissue mass.

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Effect of Indigestible Polysaccharides on Accumulation of Pentachlorobenzene in Rats

Cited by 2 publications

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Effects of Sodium Alginate and Fish Oil to Reduce Trichloroethylene Accumulation i Rats.

Effects of Sodium Alginate and Fish Oil to Reduce Trichloroethylene Accumulation i Rats.

Guar Gum Reduces Trichloroethylene Accumulation in the Body by Reducing TCE Absorption and Fat Tissue Mass

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